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http://repo.knmu.edu.ua/handle/123456789/31239
Назва: | Single nucleotide polymorphism C994g of the cytochrome P450 gene possess pleiotropic eff ects in Bos taurus, L. |
Автори: | Fedota, Olena Puzik, Nina Skrypkina, Inessa Babalyan, Volodymyr Mitiohlo, Larysa Ruban, Serhii Belyaev, Serhii Borshch, Oleksandr Borshch, Oleksandr |
Теми: | cattle cytochrome P450 mycotoxin contamination pleiotropic eff ect single-nucleotide polymorphism (SNP) |
Дата публікації: | 2022 |
Видавництво: | University of Szeged |
Бібліографічний опис: | Single nucleotide polymorphism C994g of the cytochrome P450 gene possess pleiotropic effects in Bos taurus, L. / O. Fedota, N. Puzik, I. Skrypkina, V. Babalyan, L. Mitiohlo, S. Ruban, S. Belyaev, O. O. Borshch, O. V. Borshch // Acta Biol. Szeged. — 2022. — Vol. 66, No. 1. — P. 7–15. |
Короткий огляд (реферат): | The chronic consumption of mycotoxin-contaminated forage tends to the weight loss of young cattle, decreasing the reproductive success of adult animals, milk yield, and tolerance to high temperatures. The aim of this paper was to study the effects of the SNP C994G in the CYP3A28 gene on the productive and reproductive characteristics of dairy and beef breeds. Cows were measured by body weight dynamics, exterior, reproduction, milk production traits, bone mineral density, bulls were analyzed estimating their progeny traits. Dairy cows received dietary betaine supplement with the measurement of homocysteine levels. Molecular genetic was performed by PCR-RFLP method. The eff ects of SNP C994G were shown in relation to the udder size, the constitution and birth weight of Abredin-Angus cows, as well as the fat and protein content of Ukrainian Red-and-White Dairy cows milk. The higher sensitivity of the GG genotype to less homocysteine level after the addition of betaine was shown. Given the identified correspondence, pleiotropic effects of CYP3A28 gene can be concluded. A microscopic analysis of forage supported the findings in relation to greater effi ciency of the CC genotype under conditions of low mycotoxins contamination, to which CYP3A28 is selective. |
URI (Уніфікований ідентифікатор ресурсу): | http://repo.knmu.edu.ua/handle/123456789/31239 |
ISSN: | 15884082 |
Розташовується у зібраннях: | Наукові праці. Кафедра медичної біології |
Файли цього матеріалу:
Файл | Опис | Розмір | Формат | |
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Fedota_SNP_C994g_cytochromeP450_pleiotropy_Bos.pdf | 1,49 MB | Adobe PDF | Переглянути/відкрити |
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