Creation of anti-inflammatory pharmaceutical compositions (review)

Abstract

The review article summarizes the data of literature and our own research on the creation of more effective and safe domestic combined drugs with a pronounced anti-inflammatory and analgesic effect. Untimely treatment of inflammatory processes often leads to long-term incapacity and even disability, so today there is an active search for new effective and safe domestic combination drugs with pronounced anti-inflammatory and analgesic effects. Due to the constant search for innovative drugs the treatment of a significant number of diseases and pathological conditions with existing drugs remains ineffective or causes addiction and a large number of side effects. As a result, inflammatory processes can be accompanied by severe pain, spasms, increased convulsive activity of the brain, other disorders, so non-narcotic analgesics and nonsteroidal anti-inflammatory drugs are combined with other agents that can cause complementary effects or potentiate each other's effects. Caffeine is a useful adjuvant of nonsteroidal anti-inflammatory drugs of various chemical structures in terms of anti-inflammatory and analgesic effects. The article presents a literature review of the current state of treatment of inflammation and pain, conducting research to expand the therapeutic capabilities of known pharmaceuticals, the creation of pharmaceutical compositions of nonsteroidal anti-inflammatory drugs with caffeine.