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http://repo.knmu.edu.ua/handle/123456789/27403
Title: | TLR-mediated activation of peripheral blood monocyte phagocytosis in patients with multiple sclerosis |
Other Titles: | TLR-опосередкована активація фагоцитозу моноцитів периферичної крові у хворих на розсіяний склероз |
Authors: | Skliar, Anna Koliada, Oleg Vdovichenko, Nataliya Koliada, Tetyana |
Keywords: | multiple sclerosis TOLL-like receptors |
Issue Date: | 2020 |
Citation: | TLR-mediated activation of peripheral blood monocyte phagocytosis in patients with multiple sclerosis / A. I. Skliar, O. M. Koliada, N. I. Vdovichenko, T. I. Koliada // Патологія. – 2020. – Том 17, № 2 (49). – C. 288–233. – DOI: 10.14739/2310-1237.2020.2.212807. |
Abstract: | Phagocytic activity lesions of monocytes were observed both in patients with RRMS and PMS, associated mainly with FcR-mediated mechanisms of phagocytosis. IFN-β therapy in patients with RRMS led to the correction of such disorders in patients with high treatment efficacy (responders), and TLR7/8-mediated activation of monocytes was accompanied by an increase in the number of phagocytic cells. In patients with low efficacy of IFN-β therapy (nonresponders), the nature of changes in the phagocytic activity of stimulated monocytes indicated a decrease in the functional reserve with regard to FcR-mediated phagocytosis. The obtained results indicate differences in phagocytic activity indices during stimulation of TLR4 and TLR7/8 and may indicate the presence of functional and phenotypic alterations of peripheral blood monocytes depending on the ef¬fectiveness of MS treatment. |
URI: | https://repo.knmu.edu.ua/handle/123456789/27403 |
Appears in Collections: | Наукові праці. Кафедра загальної та клінічної патофізіології імені Д.О. Альперна |
Files in This Item:
File | Description | Size | Format | |
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TLR-MEDIATED ACTIVATION OF PERIPHERAL BLOOD MONOCYTE PHAGOCYTOSIS.pdf | 977,14 kB | Adobe PDF | View/Open |
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