Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/22124
Title: | A study of erythrocyte membranes in carrageenaninduced gastroenterocolitis by method of fluorescent probes |
Authors: | Tkachenko, Anton Marakushyn, Dmytro Rezunenko, Yurii Onishchenko, Anatolii Nakonechna, Oksana Posokhov, Yevgen |
Keywords: | erythrocytes biomembrane carrageenan-induced gastroenterocolitis fluorescent probe |
Issue Date: | 2018 |
Publisher: | HVM Bioflux |
Citation: | A study of erythrocyte membranes in carrageenaninduced gastroenterocolitis by method of fluorescent probes / A. S. Tkachenko, D. I. Marakushyn, Y. K. Rezunenko, A. I. Onishchenko, O. A. Nakonechna, Y. O. Posokhov // HVM International Journal of the Bioflux Society. – 2018. – Vol. 10, Is. 2. – P. 37–41. |
Abstract: | Objective. The aim of our research was to investigate erythrocyte membranes of rats with carrageenan-induced gastroenterocolitis using fluorescent probes (ortho-hydroxy derivatives of 2,5-diaryloxazole).Materials and methods. Fluorescence of O1O (2 - (2’-OH-phenyl)-5-phenyl-1,3-oxazole) and PH7 (2-(2’-OH-phenyl)-phenanthro[9,10]-1,3-oxazole) probes in suspensions of erythrocytes of rats with chronic carrageenan-induced gastroenterocolitis was determined and compared to the control group consisted of intact animals.Results. It has been found that the hydration of erythrocyte membranes increases in rats with carrageenan-induced gastroenterocolitis. The disease is associated with the changes in the polar regions of the membranes, while no changes in the hydrophobic areas of the erythrocyte membranes are observed. Conclusion. The detected changes allow us to make a conclusion that the fluidity of the erythrocyte membranes of the rats with chronic carrageenan-induced gastroenterocolitis increases. |
URI: | https://repo.knmu.edu.ua/handle/123456789/22124 |
Appears in Collections: | Наукові праці. Кафедра біологічної хімії |
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