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Title: | The effect of phosphorus organic mixtures on chromosome aberration and cells’ mitotic activity of red bone marrow in the subacute experiment |
Authors: | Bagmut, Irina Zharova, Nataliya Titkova, Anna Boiagina, Olga Rezunenko, Yu. Боягіна, Ольга Дмитрівна Жарова, Наталія Валентинівна Тіткова, Анна Володимирівна Багмут, Ірина Юріївна Резуненко, Юрій Костянтинович |
Keywords: | xenobiotics phosphorus detergents cells' mitotic activiy red bone marrow rats |
Issue Date: | Dec-2017 |
Citation: | The effect of phosphorus organic mixtures on chromosome aberration and cells’ mitotic activity of red bone marrow in the subacute experiment / I. Yu. Bagmut, N. V. Zharova, A. V. Titkova, O. D. Boiagina, Yu. K. Rezunenko // The quarterly review of biology. – 2017. – Issue 4 (2), vol. 92. – Р. 701–705. |
Abstract: | At 100 Wistar rats population in subacute experiment the effect of small sub-toxic doses of phosphorus detergents (Efasol, Polifos, Syntaf) on the level of chromosomal aberrations and cells' mitotic activity of red bone marrow was investigated. There were 9 research groups of animals and one control in certain clear relationship between dose intensity and toxic effects of restructuring chromosomal apparatus. The number of cells with chromosomal aberrations in a dose-dependent (1/10, 1/100 LD50) increased from 5 to 10 times. The study of cells' mitotic activity of red bone marrow identified reducing mitotic index, which may indicate the cytostatic effect of phosphorus detergents in appropriate doses 1/10 and 1/100 LD50. All xenobiotics in 1/1000 LD50 dose did not affect the genetic apparatus of male rats. |
URI: | https://repo.knmu.edu.ua/handle/123456789/18157 |
ISSN: | 0033-5770 |
Appears in Collections: | Наукові праці. Кафедра анатомії людини |
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