Кафедра пропедевтики педіатрії № 2

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Author: search.filters.author.Klymenko, Viktoriia

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    Allergic rhinitis symptoms prevalence In children of Kharkiv
    (2021) Klymenko, Viktoriia; Karpushenko, Juliia; Drobova, Nadiia; Kozhyna, Olga
    The purpose of the study was to identify the prevalence of allergic rhinitis (AR) symptoms in children of Kharkiv and to establish the dynamics of symptoms since 1998. The study conducted in 2015–2017 is phase IV of the international ISAAC program. 5735 children were interviewed, including 3238 children aged 6–7 years and 2197 children aged 13– 14 years. The incidence of non-cold-related sneezing was found in 14.7 % and 16.1 %, respectively; during the past 12 months similar problems with nose breathing were noted in 9.1 % and 9.9 %; accompanied by conjunctivitis – in 3.4 % and 4.8 % of children of 6–7 and 13–14 years, respectively. Most patients had seasonal exacerbations and mild/moderate rhinitis. AR diagnosis was verified in 12.2 % and 11.3 % of children, respectively. Decreasing of AR symptoms prevalence was found in children of all ages. The dynamics of AR symptoms prevalence, "eye" symptoms over the past 20 years show a probable decrease in all indicators, which can be explained by the widespread introduction in medical practice of screening methods for the disease diagnosing, activation of primary and secondary prevention.
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    The method for predictive assessment of the condition of patients with atopic dermatitis at different stages of the disease
    (2021) Avrunin, Oleg; Trubitcin, Alexey; Klymenko, Viktoriia
    The subject of the research is the development of a method for prognostic assessment of the condition of patients with atopic dermatitis at different stages of the disease. The goal of the work is to study the informativeness of immunological indicators and data from dermatoscopic examinations in order to expand the possibilities of prognostic objectification of methods for assessing the condition of patients with atopic dermatitis with varying degrees of severity of the disease. The task of the work includes objectifying the blurring of assessment standards when analyzing the transition from one stage of the disease to another. Methods. The solution to this problem is possible when assessing the possibility of using models of parametric recognition (discrimination) using indicators of immunoglobulins in blood serum and indicators of immunograms, as well as color characteristics of skin areas based on the analysis of dermatoscopic images at various degrees of severity of the disease. Result. In the course of the study, the analysis of the color characteristics of the skin showed that when immunological blood parameters are added to the discrimination model, the probability of an error in making prognostic decisions significantly decreases. Predictive assessment of the condition of a patient with atopic dermatitis only by the color characteristics of the skin makes it possible to control this pathology with a higher degree of probability, which makes it possible to use the digital dermatoscopy method independently for express objectification of the condition of a patient with atopic dermatitis without waiting for the data of immunological analyzes. When a new patient appears, the above indicators are calculated for him and the normalized Euclidean distances to the center of the clusters corresponding to the studied pathologies are calculated. The calculated distances can be ranked and the probabilities of correspondence of the given case to specific pathologies can be determined. Conclusions. The prospect of further work is to substantiate the metrological characteristics of the method to eliminate possible systematic errors associated with the method of obtaining optical information.
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    Cystic fibrosis social aspects in Ukraine
    (National Health as Determinant of Sustainable Development of Society. Editors: Nadiya DUBROVINA & Stanislav FILIP. Monograph. School of Economics and Management in Public Administration in Bratislava, 2021) Klymenko, Viktoriia; Piontkovska, Oksana; Pasichnyk, Olena; Drobova, Nadiia
    Cystic fibrosis (CF) is a genetically determined pathology. It belongs to the orphan diseases group. CF is an important social problem not only in Ukraine but also all over the world. The main social problems of CF patients in Ukraine are insufficient and late diagnosis of the disease, lack of genetic passport of most patients, severe disease course with psychological problems in the family, lack of access to high-tech treatment algorithms (gene therapy, lung transplantation), short life expectancy and difficult financial position. In recent years, there have been the number of positive changes in the treatment and management of CF patients in Ukraine. Implementation of international standards of treatment and care is the only way to improve the life quality of CF patients.
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    Communication problems with the patient in hospice and medical and social institutions for palliative care
    (2021) Dubrovina, Nadiya; Kolesnikova, Olena; Klymenko, Viktoriia; Shkrabiuk, Veronika
    The article discusses the features of communication with patients in hospices and medical and social institutions for palliative care. The role of medical personnel in communication with a dying patient and his relatives is presented. The features of communication with pediatric patients in hospices are shown, taking into account their age and state of health.
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    Causes of uncontrolled bronchial asthma among children in Kharkiv region
    (2021) Klymenko, Viktoriia; Piontkovska, Oksana; Kulik, Tetiana
    Bronchial asthma (BA) is one of the most common chronic diseases, according to WHO statistics in 2018, there were about 334 million patients worldwide, and 14% of them were children. BA among children reduces the quality of life, is one of the main reasons for skipping school days, can be a cause of disability and sometimes death. The aim of the work was to improve the uality of life of children with asthma by improving disease control. 50 children with asthma were examined. The study included a study of complaints of the patient and his parents, medical history, the results of clinical and laboratory and instrumental examinations. The main reason for the lack of control among children with asthma is the violation of the algorithms of basic therapy.
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    A Partly Fermented Infant Formula with Postbiotics Including 30 -GL, Specific Oligosaccharides, 20 -FL, and Milk Fat Supports Adequate Growth, Is Safe and Well-Tolerated in Healthy Term Infants: A Double-Blind, Randomised, Controlled, Multi-Country Trial
    (Nutrients, 2020) Vandenplas, Yvan; de Halleux, Virginie; Arciszewska, Małgorzata; Lach, Piotr; Pokhylko, Valeriy; Klymenko, Viktoriia; Schoen, Stefanie; Abrahamse-Berkeveld, Marieke; Kelly, A Mulder; Rocio, Porcel Rubio
    This study investigated growth, safety, and tolerance in healthy infants consuming a partly fermented infant formula (IF) with postbiotics, 20-linked fucosyllactose (20-FL), a specific prebiotic mixture of short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS), and milk fat. This double-blind, controlled trial randomised 215 fully IF-fed infants ≤14 days of age to either: Test Group (IF) containing 26% fermented formula with postbiotics derived from Lactofidus fermentation process (including 30 -Galactosyllactose; 30 -GL), 0.8 g/100 mL scGOS/lcFOS (9:1), 0.1 g/100 mL 20 -FL, and milk fat), or Control group (IF with 0.8 g/100 mL scGOS/lcFOS (9:1)) until 17 weeks of age. Fully breastfed infants were included as a reference. Anthropometric measures, gastrointestinal symptoms, and safety were assessed monthly. Equivalence in weight gain (primary outcome) between the Test and Control groups was confirmed (difference in means −0.08 g/d; 90% CI (−1.47;1.31)) with estimated mean weight gain (SE) of 31.00 (0.59) g/d and 31.08 (0.60) g/d, respectively, (PP population, n = 196). Equivalence in length and head circumference gain between the randomised groups was also confirmed. No statistically significant differences were observed in adverse events or gastrointestinal tolerance between randomised IF groups. A partly fermented IF with postbiotics, specific oligosaccharides, 20 -FL, and milk fat supports adequate infant growth and is safe and well-tolerated in healthy term infants.
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    Characteristics of immune status in children with cystic fibrosis
    (2020) Klymenko, Viktoriia; Piontkovska, Oksana; Drobova, Nadiia; Pasichnyk, Olena; Shelest, Svitlana
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    Possibilities for assessing the effectiveness of treatment of atopic dermatitis based on analysis of color characteristics of video dermatoscopic images
    (2020) Avrunin, Oleh; Trubitcin, Alexey; Isaeva, Olga; Klymenko, Viktoriia
    The subject of the article is the study of the color characteristics of video dermatoscopic images of affected skin areas of children with atopic dermatitis and the development of an automated diagnostic system for processing and analysis of dermatoscopic images. The aim of the work is to develop an objective method for assessing the skin condition of children with atopic dermatitis based on numerical analysis of images of affected skin areas. The objectives of the work were to collect a life history of children with atopic dermatitis, study the color characteristics of video dermatoscopic images of affected skin areas and further develop an automated diagnostic system for processing and analyzing dermatoscopic information. Research Methods. During the diagnostic examinations of children with atopic dermatitis, a history of life was collected and the initial dermatological status of patients was described. A comprehensive assessment of the severity of the disease was performed using the SCORAD index. Image registration was carried out using a UM039 digital video dermatoscope with optical magnification up to 200 times, resolution of the receiving matrix 2880 × 1800 image elements, equipped with a built-in block of adjustable LED lighting, a tripod and a rotary 3-inch display. The images were captured on a microSD card with subsequent transfer of data to the database on the computer. The results of the study, based on the data obtained, allowed us to assess the intensity and dynamics of the inflammatory processes of the affected areas of the skin of children with atopic dermatitis and to formulate the principles of the automated diagnostic system for processing and analysis of dermatoscopic images. Conclusion. At the end of the study, the authors conclude that to monitor the skin condition in the treatment of atopic dermatitis, the analysis of the color components of the affected areas on the HSV scale can be used, which allows the specialist to intuitively observe the results of the therapy in a natural color space for human perception. As prospects for the development of the work, the authors substantiate the prerequisites for the development of a complete automated system for the comprehensive diagnosis of atopic dermatitis and its clinical trial. Such a system can make it possible to form a preliminary diagnosis and determine the severity of the disease based on the evaluation of color channels of images of affected skin areas and additional diagnostic data.
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    Prevalence of Bronchial Asthma Symptomatic Manifestation among Children of Kharkiv
    (2019) Klymenko, Viktoriia; Kozhyna, Olga; Zemlianskyi, Konstantin
    The aim of the work was to improve the diagnosis of bronchial asthma (BA) in the pediatric population by revealing the current prevalence of symptoms using an epidemiological method and identifying trends in the prevalence of symptoms since 1998. The study was performed in 2017 in Kharkiv. The standardized method of the International Study of Asthma and Allergy in Childhood (ISAAC) was used. The volume of the sample was calculated according to the formula for sample population determining and ensures the representativeness of the data obtained (Lisitsin Y.P., 1987), which amounted to 5434 children. 3374 parents of children 6–7 years old and 2552 children 13–14 years old were surveyed; in total 5926 students, which accounted for 97% of the total number of uestionnaires distributed. The standardized ISAAC questionnaire contains 8 questions about the symptomatic manifestations of BA. The percentage of positive responses in children 6-7 years old was analyzed; the results are presented for 2017, 2002 and 1998, respectively. 1. The presence of ever wheezing (wheezing) in the past (the first question of the ISAAC questionnaire) was found in 13.8%; 19.4% and 24.1% of children, respectively. 2. "Wheezing" was observed in the last 12 months in 6.6%; 12.5%; 12.2%. 3. More than three episodes of "wheezing" in the past 12 months were found in 0.9%; 2.5% and 2.3%. 4. Sleep disturbance from "wheezing" one or more nights a week during the last 12 months occurred in 1.9%; 1.3% and 1.4%. 5. Speech was limited to wheezing during the last 12 months in 0.5%; 1.7% and 1.5%. 6. The presence of asthma in the history was noted in 1.5%; 6.8% and 5.5%. 7. "Wheezing" in chest during or after exercise during the last 12 months was at 2.0%; 10.4% and 4.6%. 8. Dry cough at night (not associated with a cold or inflammatory diseases) over the past 12 months was noted at 6.9%; 13.7% and 11.9% of children. The percentage of positive answers to 8 questions of the ISAAC questionnaire in children 13-14 years was analyzed. The results are presented on issues for 2017, 2002 and 1998 respectively: 1. - 9.9%; 29.6%; and 25.3%. 2. - 3.4%; 20.9% and 12.9%. 3. - 0.4%; 2.5% and 1.2%. 4. - 0.6%; 1.1% and 0.8%. 5. - 0.5%; 2.3% and 1.9%. 6. - 1.6%; 5.5% and 6.1%. 7. - 2.8%; 20.6% and 13.2%. 8. - 4.6%; 19.3% and 12.1%. The obtained results and the dynamics of prevalence are analyzed in comparison with both average and individual data for different regions and countries of the world. The current prevalence of respiratory symptoms in children of Kharkiv was revealed in 15.9% (10.1% in the younger school age, 5.8% in the adolescent age). The trends to reduce both the prevalence and severity of BA manifestations in the region over the past 20 years have been identified. Attention is focused on the low level of diagnosis of BA.