Наукові праці. Кафедра пропедевтики внутрішньої медицини № 1, основ біоетики та біобезпеки
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Item Level of TNF-α, sTNF-RI and 8-isoprostane in the combined therapy of lacidipine and candesartan at overweight hypertensive patients(2016-05) Ashcheulova, Tetyana; Kovalyova, Olga; Gerasimchuk, NinaOne of the manifestations of the pathogenesis of such combined pathology as hypertension (AH) and obesity is the development of endothelial dysfunction (ED). Recent studies suggest a possible role of immune-inflammation activation mediated by pro-inflammatory cytokines, and oxidative stress (OS) in the development of ED.Item Distant apoptosis markers in human hypertension(2014) Ashcheulova, Tetyana; Ащеулова, Тетяна Вадимівна; Ащеулова, Татьяна Вадимовна; Kovalyova, OlgaDISTANT APOPTOSIS BIOMARKERS IN HUMAN HYPERTENSION Ashcheulova T, Kovalyova O. The aim was to study plasma apoptosis markers (TNF-α, sTNF-R1, sFasL) levels in patients with arterial hypertension (AH) depend on degree of blood pressure elevation. We examined 78 patients with AH, which were divided into 3 groups depend on AH degree: 1 group (n=18) – 1 degree AH, 2 group (n=25) – 2 degree AH, 3 group (n=35) – 3 degree AH. Plasma tumor necrosis factor-α (TNF-α), soluble TNF receptors type 1 (sTNF-R1), and soluble Fas ligand (sFasL) levels by ELISA were detected. It was found that plasma TNF-α levels in all groups patients were higher than in healthy normotensives (p<0.05). Maximum mean was detected in 2 degree AH patients. Circulating sTNF-R1 levels of all groups patients were elevated vs normal means (p<0.05). In spite of detected increasing sTNF-R1 concentration, natural TNF-α inhibitor, and insignificant decreasing of TNF-α/sTNF-R1, cytokine level remained high, that confirm possibility of TNF-mediated apoptosis pathway in hypertensive patients. Obtained results indicate possibility of Fas-related apoptosis in patients with arterial hypertension. Conclusion. Result of our clinical study showed increased immuno-inflammatory and proapoptotic activity depends on presence and degree of arterial hypertension.Item Hypertriglyceridemic waist phenotype: a marker of cardiometabolic risk in patients with arterial hypertension(2014) Ashcheulova, Tetyana; Kovalyova, Olga; Sayed, Mudjaheed AbbasHypertriglyceridemic waist phenotype in patients with arterial hypertension was examined. Patients were categorized into 3 phenotype groups based on waist circumference means and plasma triglyceride levels: group 1 included patients (n=10) with normal waist circumference (< 90cm in men and < 85 cm in women) and elevated plasma triglyceride levels (≥ 1.7 mmol/l); group 2 included patients (n=25) with increased waist circumference (≥ 90 cm in men and ≥ 85 cm in women) and normal triglyceride level (< 1.7 mmol/l); group 3 include patients (n=66) with increased waist circumference (circumference ≥ 90 cm in men and ≥ 85 cm in women) and increased plasma triglyceride levels (≥ 1.7 mmol/l) that is with hypertriglyceridemic waist phenotype. The result of our clinical study of patients with arterial hypertension showed that hypertriglyceridemic waist phenotype was associated with elevated SBP, DBP levels; increased body mass, BMI; increased pro-inflammatory cytokine – IL-18 activity; highest glucometabolic risk and atherogenic metabolic risk profile. Our results can suggest that hypertriglyceridemic waist phenotype is a simple and inexpensive marker to help identify patients with high cardiometabolic risk profile, and also can be used as a simple screening approach to predict development of type 2 diabetes mellitus.Item Interleukin-18, Interleukin-10 plasma levels in patients with arterial hypertension depend on type 2 diabetes mellitus presence(2012) Kovalyova, Olga; Ashcheulova, Tetyana; Al Sheikh Deeb, Hussein HamzehItem Hypercytokinemia and cardiac decompensation in hypertensive patients(2012-12) Ashcheulova, Tetyana; Kovalyova, OlgaItem TNF-alpha, IL-10, IL-6 serum activity in patients with obesity-associated arterial hypertension depend on bronchial obstruction presence(2012) Ashcheulova, Tetyana; Sytnik, KseniaItem Adipokines, glucometabolic disorders, abdominal obesity in hypertensive patients(2012) Ashcheulova, Tetyana; Ambrosova, Tetyana