Наукові праці. Кафедра неврології № 2
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Item Clinical-morphological pecularities of the peripheral nervous system in different types of the multiple sclerosis course(Белорусский государственный медицинский университет, 2018) Марковская, Елена Владимировна; Шапкин, Антон Сергеевич; Лунина, Алина Олеговна; Markovska, Olena; Shapkin, A.; Lunina, A.Summary: in the study of peripheral nervous system structures in patients with multiple sclerosis, demyelination and dystrophic changes of nerve fibers were revealed in the form of defibration, sclerosis, focal shrinkage of Schwann cells, as well as inflammatory changes with the expression of large amounts of cyclooxygenase-2 and inducible fraction of synthase nitric oxide.Item Enzyme blood level disorder as a marker of metabolic processes severity in multiple sclerosis(2014) Markovska, OlenaDynamics of membrane-bound enzymes activity changes in the blood of 67 patients with multiple sclerosis was investigated depending on the variety and duration of the disease.Item Intensification of educational and cognitive activities of interns in the process of training(Scientific publishing house Infinity, 2020-04-12) Markovska, Olena; Tovazhnyanska, Olena; Markovskyi, Volodymyr; Shapkin, AntonThe introduction of modern teaching methods on the “Neurology” cycle for interns has significantly improved the assimilation of special skills and abilities and the acquisition of theoretical and practical knowledge in the diagnosis, treatment, prevention, and the provision of adequate assistance in emergency situations in people with pathology of the nervous system. The effectiveness of these activities was noted during the final exam. So, the percentage of “excellent” answers on emergency neurology has significantly increased - up to 50% against 27% with traditional approaches to training.Item Multiple sclerosis. Possible options for the onset of the disease in a clinical example(Scientific publishing house Infinity, 2020-05) Markovska, Olena; Tovazhnyanska, Olena; Nadozirna, Yevheniia; Lapshyna, IrynaMultiple sclerosis (MS) is a neurological problem of great socioeconomic importance, as it develops mainly in young and middle-aged people and, in the absence of timely and adequate treatment, leads to the formation of severe neurological deficit and early disability of patients in the first year after diagnosis. The clinical manifestations of MS are diverse and the well-known slow onset and development of the disease are not always found. A variety of clinical forms and options for the onset of MS, an increase in the age interval for debut, various rates of disease progression indicate different mechanisms for the development of the demyelinating process and thereby increase interest in studying the clinical features and pathogenetic mechanisms of the development of this pathology.Item Transcranial dopplerography in acute left-hemispheric ischemic stroke(2018-03) Абдуллаев, Ризван Ягубович; Сисун, Лариса Анатольевна; Товажнянская, Елена Леонидовна; Посохов, Николай Федорович; Марковская, Елена Владимировна; Abdullaiev, Rizvan; Sysun, L.; Tovazhnyanska, O.; Posokhov, N.; Markovska, OlenaIn patients with hemispheric chemical stroke, stenosis of the middle cerebral artery is often observed, a systolic blood flow velocity less than 70 cm/s, an increase in the resistance and pulsation index. On the contralateral side, in persons up to 60 years of age, the blood flow velocity may be slightly increased in comparison with healthy individuals. Reduction of systolic blood flow velocity, increase in resistance index more than 0.70, pulsative index more than 1.35, presence of deep incision on Doppler spectrum of blood flow in middle cerebral artery are prognostic signs of unfavorable course of ischemic stroke. With ischemic stroke on the side of the lesion, visualization of the deep veins of the brain improves because of the increase in speed in themItem Ultrasonographic characteristics of carotid and middle cerebral arteries in patients with ischemic stroke(Research advances in brain disorders and therapy, 2018-07-05) Абдуллаев, Ризван Ягубович; Когут, Александра Валерьевна; Григорова, Ирина Анатольевна; Товажнянская, Елена Леонидовна; Посохов, Николай Федорович; Марковская, Елена Владимировна; Тесленко, Ольга Александровна; Abdullaiev, Rizvan; Kogut, A.; Hryhorova, I.; Tovazhnyanska, O.; Posokhov, N.; Markovska, Olena; Teslenko, O.Atherosclerotic lesions of carotid and large cerebral vessels are an important cause of stroke, which leads to a higher risk of early recurrent ischemia than any other stroke subtype. Extra cranial ultrasound and Transcranial Dopplerography (TCD) in triplex mode is a non-invasive approach to obtaining qualitative changes in the carotid and middle cerebral arteries, and the quantitative parameters of the blood flow in them.The relationship between the nature of atherosclerotic plaque, the degree of stenosis of the internal carotid artery and the frequency of occurrence of ischemic stroke are established. Ulcerated and embologenic plaques in the carotid arteries, stenosis of the internal carotid artery more than 70% increase the risk of ischemic stroke. Hemodynamically significant stenosis of the middle cerebral artery can be diagnosed by color Doppler in more than 70% of patients with ischemic stroke.