Кафедра загальної та клінічної патологічної фізіології імені Д.О. Альперна
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Item Changes in vascular endothelial function in rats with experimental scopolamine-induced alzheimer-type dementia(2023) Pavlova, Olena; Lukyanova, YevgeniaItem Characterization of the effect of chronic immobilization stress on the structural and functional state of the liver of mother rats and their one-month-old offspring as a risk factor for liver cancer(2023) Kuznetsova, Milena; Bibichenko, Viktoriia; Kuznetsova, Irina; Sarapulova, SnizhanaItem Chronic inflammatory processes of the maternal genitourinary system, its role in cardiovascular diseases development in their children: Ukrainian and European experience of prevention as the key to the health of future generations(2023) Olianych, Serhii; Myroshnychenko, Mykhailo; Pasiyeshvili, Nana; Kapustnyk, Nataliia; Bibichenko, VictoriaCardiovascular diseases (CVDs) remain the leading cause of morbidity in the world. The burden of CVDs continues to increase over the past decade in almost all countries of the world. The prevalence of CVDs in the world has almost doubled from 271 million i 1990 to 523 million in 2019. The number of deaths from CVDs over the same period has increased by twofold from 12.1 million to 18.6 million. The indicators of years of life with disability and lost years also doubled in total from 17.7 million in 1990 to 34.4 million in 2019. Data from Ukrainian and European statistics testify to the need for timely active measures aimed at preventing the development of CVDs. Modern strategies for the prevention of CVDs are primarily aimed at correcting the known risk factors: quitting smoking, regular physical exercise, normalizing body mass index, glucose, normalizing blood pressure, etc. What is not taken into account in this strategy? The very first periods of a human life, which significantly program health, duration and quality of life, remain beyond attention. In the structure of genital and extragenital pathology of women of reproductive age, significant parts are inflammatory diseases of the genitourinary system, which are characterized by predominantly chronic course. Simultaneous development of inflammatory diseases of the urinary and reproductive systems is explained by the facts that these systems organs develop from one primary germ layer (mesoderm), they have a close anatomical-physiological connection, a common blood supply and lymphatic system, and are also target organs of sex hormones activity. Babies born prematurely are at a greater risk of developing heart failure later in life. The incidence of heart failure in individuals born extremely prematurely (less than 28 weeks gestation) was 17.0 times higher compared to those born at term (37 weeks or more), after taking into account other factors. Similarly, those born very prematurely (28 to 31 weeks gestation) had an incidence of heart failure 3.58 times higher compared to term births. The analysis of the research results of Ukrainian and European scientists has shown that chronic inflammatory processes of the genitourinary system of the mother are a significant damaging factor that can change the morphological and functional state of the fetal and newborn cardiovascular system and cause the development of CVDs at various stages of ontogenesis. Thus, chronic inflammatory processes of the mother's genitourinary system are one of the factors that can cause the development of CVDs in children at different stages of ontogenesis. The classic concept of CVDs prevention should be supplemented taking into account the programming effect of harmful factors that act on the preconception and prenatal stages and reliably increase the risk of CDVs development. Among the reproduktive age, it is extremely necessary to carry out measures aimed at prevention, timely diagnostics and treatment of infectious and inflammatory diseases of the genitourinary system.Item Composite ceramics as a modern trend in dental medicine(2023) Gevorkyan, E.; Morozova, O.; Nerubatskyi, V.; Morozov, O.Item Ethical aspects of conducting research: point of view of medical university students(2023) Topoliuk, Kateryna; Tsymbal, Maryna; Myroshnychenko, MykhailoItem Features of psycho-emotional status disorders of medical students in the conditions of full-scale war(2023) Buha, V.; Huliieva, V.; Sliusarenko, D.; Boiko, I.; Kovaltsova, M.; Myroshnychenko, M.Item General pathophysiology: methodical instructions for the practical class for foreign students (majoring in «Medicine» and «Dentistry»)(2023) Myroshnychenko, Mykhailo; Safarhalina-Kornilova, N.; Bibichenko, V.; Kucheriavchenko, M.; Pavlova, O.; Shevchenko, O.; Kovaltsova, M.; Koliada, O.; Kuznetsova, M.; Kuzmina, I.; Lytvynenko, O.; Morozov, O.Item The impact of external positive motivation for obtaining education among students of a medical university(2023) Myroshnychenko, Mykhailo; Kuznetsova, Milena; Bibichenko, Viktoria; Myroshnychenko, SerhiiItem The level of the macroelement calcium under the conditions of the influence of a hypercaloric diet on the pancreas of experimental animal(2023) Kovaltsova, Maryna; Myroshnychenko, Mykhailo; Sirenko, Viktor; Boiko, I.; Sliusarenko, D.; Huliieva, V.; Buha, V.Item Macrophages and their phenotypic variability in the skin with underlying soft tissues in patients with multiple sclerosis(2023) Sukharieva, Liliia; Markovska, OlenaItem Reactive oxygen species generation by blood leucocytes of rats with polycystic ovary syndrome under the conditions of intermittent cold exposure(2023) Zhulikova, Maryna; Myroshnychenko, Mykhailo; Nakonechna, Oksana; Zhulikov, Oleh; Pustova, Nataliia; Bibichenko, Viktoriia; Lytvynenko, Olena; Kucheriavchenko, MarynaThe aim of this study was to determine the level of ROS production by blood leukocytes of rats with PCOS under the conditions of intermittent cold exposure. Materials and methods: In the study, 40 immature female rats of the WAG population at the age of 27 days with a body weight of 80-90 g were used. Five groups were formed (8 animals in each group). Group 1 was represented by intact rats that were not subjected to any manipulations. Group 2 was represented by rats that were injected subcutaneously with 0.2 ml of purified and sterilized olive oil daily for 25 days. Group 3 was represented by rats that were exposed to intermittent cold for 25 days. Group 4 was represented by rats that were modeled with PCOS. Group 5 was represented by rats, which were simulated PCOS against the background of intermittent cold exposure. ROS production was estimated in leukocytes isolated from rats of all groups by flow cytometry using the fluorescent probe of 2,7-dichlorodihydrofluorescein diacetate (H2DCFDA). Results: The experimental study revealed an intracellular excessive production of ROS by leukocytes in rats with polycystic ovary syndrome. The use of intermittent cold exposure normalized the production of reactive oxygen species by leukocytes in rats with polycystic ovary syndrome. Conclusions: The effectiveness of intermittent cold exposure, proven by the authors, allows recommending its use as one of the methods of prevention and treatment of the polycystic ovary syndrome.Item The role of prostaglandin pgd2 in the pathogenesis of allergic asthma(2023) Shevchenko, O.; Veliieva, L.Item Role of risk factors in the development of endometriosis(2023) Tsinkevych, Yulia; Kuznetsova, MilenaItem Role of sulfide anion in the development of chronic alcoholic hepatitis under the conditions of modulation of adenosine monophosphate kinase – a correlational study(2023) Mykytenko, Andrii; Akimov, Oleh; Shevchenko, Oleksandr; Neporada, KarineIntroduction and aim. Hydrogen sulfide (H2S) has attracted the attention of researchers as a novel signaling molecule that affects vascular metabolism, immune function, stress and inflammation. It plays an important role in pathophysiological disorders under the conditions of the development of obesity, diabetes, non-alcoholic fatty liver disease and cardiovascular diseases. The purpose of this work is to establish correlation ratios of H2 S concentration with markers of oxidative-nitrosative stressand extracellular matrix metabolism of the liver during chronic alcoholic hepatitis modeling and AMPK modulation by phenformin and doxorubicin. Material and methods. The experiments were performed on 36 white, sexually mature male Wistar rats, weighing 180-220 g. Alcoholic hepatitis was modelled by alcohol administration, on the background of alcoholic hepatitis animals received phenformin orally at a dose of 10 mg/kg or doxorubicin at a dose of 1.25 mg/kg intraperitoneally. Statistical processing of the results of biochemical studies was carried out using the non-parametric method of Spearman to determine correlations. Results. H2S during alcoholic hepatitis inversely proportionally strongly correlates with the concentration of nitrites, oxyproline and arginase activity. Phenformin administration during alcoholic hepatitis leads to formation of inversely proportionally strongly correlation of H2 S with the production of superoxide anion radical, the concentration of malondialdehyde, activities of constitutive NO-synthases, nitrite reductases, nitrate reductases, and arginase. Doxorubicin administration during alcoholic hepatitis leads to formation of directly proportional strongly correlation of H2S with the activity of constitutive NO-synthases, nitrite reductases, nitrate reductases. Conclusion. Administration of phenformin or doxorubicin expands correlations between H2S and indicators of oxidative-nitrosative stressItem The role of the teacher in forming a healthy lifestyle in future doctors in the conditions of war(2023) Kuznetsova, Milena; Bibichenko, Victoria; Kuznetsova, IrynaIn recent years, morbidity and mortality rates among the population have increased in Ukraine. The fact that the specific weight of chronic forms of diseases has increased is particularly worrying. Equally important is the awareness of the essence of a healthy lifestyle, as purposeful actions aimed at preserving health. It has been proven that a healthy lifestyle includes a rational diet, maintaining optimal physical activity, control of bad habits and avoiding stress. Therefore, the teacher's work on forming motivation to follow a healthy lifestyle is extremely important, since this goal can be achieved by example and educational work. The purpose of this study was to determine the teacher's influence on the formation of motivation to maintain a healthy lifestyle during wartime. Materials and methods. To achieve the established purpose of the study, a survey was conducted among students of Kharkiv National Medical University (38 students), medical faculty of V. N. Karazin Kharkiv National University (35 students) and I. Ya. Horbachevsky Ternopil National Medical University (29 respondents). In total, 102 respondents aged 17 to 22 were interviewed, of whom 58 were girls and 44 were boys. In order to conduct the survey, standardized questionnaires were developed “under the following requirements: to take into account the objectives of the survey and the specificity of the contingent of respondents; to use a simple questionnaire structure (preamble, general information about the respondent, characteristics of his health, clarification questions); to maintain the interest in the survey by compliance with the requirements for the number (in our case, 20 questions) and the quality of the proposed questions (clear, concise, correct and understandable), which can ultimately allow respondents not to spend too much time filling out the questionnaire; to avoid direct questions where possible; to take into account the subjectivity of respondents' answers, and in part, their secrecy by using “filter questions” that help to reveal the reliability of assessments; if possible, to offer to choose a single answer option that reflects (if necessary, their ascending or descending hierarchy) possible changes in the parameters of the studied quantities (results, phenomena, processes)”. Results. After analyzing students' answers about the teacher's role in the formation of a healthy lifestyle, the majority noted that the teachers conducted explanatory work by visually demonstrating the positive impact of such a lifestyle, highlighting the negative role of bad habits and the consequences of their influence. Also, role-playing games were used to form healthy lifestyle skills and discussion clubs about healthy nutrition, support of student self-government in conducting activities to popularize sports (holding sports games, sports days, etc.). This study complements already existing works and expands general ideas about the extent of the teacher's influence on the formation of students' motivation to follow a healthy lifestyle. The leading way in which this was carried out was the support of student projects and research to determine the degree of influence of each of the components of a healthy lifestyle on the human body. At the same time, a whole list of issues remains unresolved, the main of which is the creation of an appropriate legislative framework that would regulate ensuring the formation of healthy lifestyle skills among the population, the absence of a state policy on ensuring healthy living conditions and student education, and the lack of systematic work on the formation of a healthy lifestyle. In addition, the lack of regular positive social advertising and the absence of a healthy lifestyle in the information space, as well as the underdevelopment of the system of returning to a healthy lifestyle, in particular discrimination and stigmatization of certain target groups of students who lead an unhealthy lifestyle, are clearly visible. Conclusions. Based on the obtained research data, it can be concluded that it is extremely important to work with the population starting from a young age for the formation of healthy lifestyle skills, regular educational work among students of higher education, visual demonstration by teachers of its benefits and highlighting with examples of harm to body from harmful habits (drug addiction, smoking, alcohol abuse). It is also beneficial to help and support in the transition to a healthy lifestyle for those students who did not follow it before.Item Scientific research in higher medical education institutions through the prism of war: ethical dimension(2023) Myroshnychenko, Mykhailo; Lazurenko, Viktoriya; Kapustnyk, Nataliia; Pasiyeshvili, Nana; Markovskyi, Volodymyr; Mishyna, MarynaItem Urogenital inflammatory diseases in women of reproductive age as a cause of an unhealthy start of children`s life: Ukrainian and European research(2023) Myroshnychenko, Mykhailo; Mishyna, Maryna; Mishyn, Yurii; Mozgova, Yuliya; Marchenko, IrynaMaternal and child health is the most important medical and social problem in the world. Modern scientific research of the world leading specialists has shown that fetus and newborn adaptive reserves depend to a greater extent on case of maternal diseases during pregnancy, especially infectious diseases, which can definitely lead to pathology of various organs and systems in fetus, defects in immune response, metabolic problems and affect life expectancy. Maternal infectious-inflammatory process in genitourinary system can act as one of the factors that damages embryogenesis of kidneys at organ, tissue and subcellular levels. Studies have shown an increase in case number of kidneys and urinary tract congenital abnormalities among children exposed to such mathernal pathology in utero. The results of Ukranian and European research indicate that chronic inflammatory diseases of mother genitourinary system are a damaging factor that leads to development of kidney pathology in children at various stages of ontogenesis. In order to prevent the development of nephropathology in children, it is absolutely necessary to carry out, firstly, measures directed to prevent the development of urogenital inflammatory diseases in women of reproductive age, and secondly, in-time detection and treatment of the specified pathology in this category of persons. Thus, the presence of chronic inflammatory diseases of the genitourinary system i pregnant woman is an unfavourable background in course of pregnancy, on which the possibilities of adaptative mechanisms are reduced or limited, various complications of pregnancy arise and fetus kidneys morpho-functional state changes. And this in future will lead to development of various kidney pathologies.Item Use of visual teaching methods to increase the level of knowledge of educators(2023) Kucheriavchenko, Maryna; Кучерявченко, Марина ОлександрівнаItem Valeological relationship of physical workability with health indicators(2023) Heera, H.S.; Najar, S.S.H.; Shevchenko, A.; Lytvynenko, O.A theoretical study is written in the form of a short report on approaches to qualitative and quantitative assessment of health and physical performance. Physical, mental, social, sexual health, their relationship to physical performance, and measurability to assess and compare individual and population outcomes are discussed. Separate models of health quality assessment and its formation are noted. Philosophical systems of understanding health, psychological approaches to its study, pedagogical systems of formation are described. It was noted that the level of physical health of a person depends on his ability to maintain the balance of homeokinesis parameters. The significance of adaptation and dysadaptation processes is described. It is proposed to draw up a "vegetative passport" of a person with an indication of the vagosympathetic balance. Physical performance, which is often evaluated together with anthropometric data, aerobic and anaerobic endurance, neuromuscular coordination, flexibility, stress resistance, is taken into account when planning sports training and professional tasks with a difficult physical component. In ordinary life, it can be reduced due to the wide distribution of hypertension, coronary disease and smoking, and frequent vascular crises. Cardiorespiratory capacity (reserves) and exercise tolerance can be carefully determined using special functional tests. The relationship between physical capacity and health indicators determined in the study allows to objectively determine tolerance to physical exertion and compare capacity in the population and in different periods of a person's life.