Browsing by Subject "antimicrobial activity"

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Antimicrobial Activity Derivatives 2H-pirano[2,3-c]piridines against Pathogens of Intestinal Yersiniosis
(Journal of Pharmacy and Nutrition Sciences, 2021) Ivannik, V.; Torianyk, I.; Moiseienko, T.; Skliar, A.; Yeromenko, R.; Hnatiuk, V.; Podrigalo, L.; Nazaryan, R.; Mikhailenko, Nina; Gargin, V.
Background: An important aspect in the treatment of patients with intestinal yersiniosis is the administration of effective antibiotic therapy. Performed research aimed to determine the spectrum and level of antimicrobial activity of 2H-pyrano[2,3-c]pyridine derivatives on the museum and clinical strains of gram-negative microorganisms Yersinia enterocolitica. Methodology: The object of the study was 28 synthetic derivatives of 2H-pyrano[2,3-c]pyridine. The compounds were studied according to their chemical structure. Weused the method of serial dilutions in Muller-Hinton liquid nutrient medium with a museum’s and clinical strains of Y.enterocolitica. Results: Studies indicate the promise of further study of the properties of 2Hpyrono[2,3-c]pyridine to create an effective antimicrobial medicine. According to theresults of studies on action of antimicrobial compounds synthesized on the basis of 2H-pyrano[2,3-с]pyridine derivatives, it was found that the MIC of compounds for all Y. enterocolitica strains was 100.0 μg/ml. The MBCC of most cultures of Yersinia (72.3 %) was 200.0 μg/ml. Compound 2{3} had a pronounced antiyersiniotic activity, the inhibitory effect of which was manifested at a concentration of 25.0 μg/ml. Retarding the growth of most Yersinia strains (95.3%) with a MIC of 50.0 μg/ml, the MIC of compounds ranged from 50.0 to 200.0 μg/ml. After statistical data processing, pyridine derivatives (compounds 2{3} and 3{5}) were identified, possessing an effective bacteriostatic and bactericidal effect on Y. enterocolitica strains. Conclusions: The results of the research showed a high antimicrobial activity of 2Hpyrano[2,3-c]pyridine derivatives. The highest activity against Y. enterocolitica wasfound for 2-N2-arylimino-5-hydroxy-methyl-8-methyl-2H-pyrano[2,3-c]pyridine-3-N1-aricarboxamide derivatives.
Antimicrobial and antioxidant activity of anthocyanin complexes of some berries' species of Ukraine
(Чорноморський національний університет ім. Петра Могили (м. Миколаіїв), 2018) Філімонова, Н.І.; Глєбова, К.В.; Шакун, О.А.; Тіщенко, І.Ю.; Босенко, О.Л.; Домарьов, А.П.; Кричковська, Л.В.; Горбач, Тетяна Вікторівна; Shakun, О.; Filimonova, N.; Gliebova, K.; Tishchenko, I.; Bosenko, O.; Domarev, A.; Krichkovskaya, L.; Gorbach, Tetiana
The aim of the study was to determine the degree of antimicrobial activity of the anthocyanin complexes of Aronia melanocarpa (Aronia melanocarpa), black currant (Ribes nigrum), elderfcerry (Sambucus nigra) with reference culture Staphylococcus aureus ATCC 25923, Escherichia coii ATCC 25922, Bacillus subtilis ATCC 6633, Pseudomonas aeruginosa ATCC 27853, Candida albicans NCTC 885-653. The highest degree of microbiological sensitivity of bacterial cultures Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa was observed in the native form of anthocyanin complexes derived from black currant (Ribes nigrum), Escherichia coli and Bacillus subtilis - to the anthocyanins in native form, derived from elder black (Sambucus nigra), which indicates their high antimicrobial activity against the microorganisms mentioned above Reducing the concentration of anthocyanins in alcoholic extract at dilu¬tion in the ratio of 1:1 and 1:2 significantly decreased the microbiological sensitivity of microorganisms to them Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa When surveying the effects of anthocyanin complexes from Aronia melanocarpa, Ribes nigrum, Sambucus nigra on Candida albicans fungi culture, no sensitivity was established, which indicates the absence of antimycotic activity of the above complexes in laboratory conditions in vitro.
Antimicrobial and antioxidant activity of anthocyanin complexes of some berries’ species of Ukraine
(2018) Філімонова, Н.І.; Глєбова, К.В.; Шакун, О.А.; Тіщенко, І.Ю.; Босенко, О.Л.; Домарьов, А.П.; Кричковська, Л.В.; Горбач, Тетяна Вікторівна; Filimonova, N.; Gliebova, K.; Shakun, О.; Tishchenko, I.; Bosenko, O.; Domarev, A.; Krichkovskaya, L.; Gorbach, Tetiana
The aim of the study was to determine the degree of antimicrobial activity of the anthocyanin complexes of Aronia melanocarpa (Aronia melanocarpa), black currant (Ribes nigrum), elderberry (Sambucus nigra) with reference culture Staphylococcus aureus ATCC 25923, Escherichia coli АТСС 25922, Bacillus subtilis ATCC 6633, Pseudomonas aeruginosa АТСС 27853, Candida albicans NСTC 885-653. The highest degree of microbiological sensitivity of bacterial cultures Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa was observed in the native form of anthocyanin complexes derived from black currant (Ribes nigrum), Escherichia coli and Bacillus subtilis – to the anthocyanins in native form, derived from elder black (Sambucus nigra), which indicates their high antimicrobial activity against the microorganisms mentioned above. Reducing the concentration of anthocyanins in alcoholic extract at dilution in the ratio of 1:1 and 1:2 significantly decreased the microbiological sensitivity of microorganisms to them Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa. When surveying the effects of anthocyanin complexes from Aronia melanocarpa, Ribes nigrum, Sambucus nigra on Candida albicans fungi culture, no sensitivity was established, which indicates the absence of antimycotic activity of the above complexes in laboratory conditions in vitro.
Некоторые аспекты нарушений микроценоза влагалища при беременности
(ТОВ «Видавничий дім «Гельветика», 2014) Щербина, Ирина Николаевна; Плахотная, Ирина Юрьевна; Липко, Оксана Петровна
Изучали количественный состав факультативной и облигатной ми- крофлоры влагалищного содержимого и его зависимость от степени тяжести вагинально- го дисбиоза у беременных, а также показате- ли антимикробной активности. Обследовано 36 женщин с вагинальным дисбиозом и 9 без признаков заболевания. Установлено, что вы- сокие значения рН влагалищного содержимо- го, низкие показатели содержания АМП и сни- жение концентрации глюкозы характеризуют тяжелую степень заболевания. Возможно, что снижение уровня АМП во влагалищном от- деляемом приводит к развитию вагинального дисбиоза.