Browsing by Author "Bezditko, Tetyana"

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    Assessment of immune parameters in obese versus non-obese asthma patients
    (2024-10-25) Yeryomenko, Galyna; Bezditko, Tetyana; DuBuske, Lawrence
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    Assessment of Systematic Inflammation and Asthma Control in Asthma Patients with Elevated BMI
    (2023-06) Yeryomenko, Galyna; Bezditko, Tetyana; Lawrence, DuBuske
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    Assessment of the Immune Status in Obese Asthma Patients.
    (2023-11) Yeryomenko, Galyna; Bezditko, Tetyana; Lawrence, DuBuske
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    Bacterial microbiome and altered immune status in perennial allergic rhinitis patients in Ukraine
    (2024-02-23) Yeryomenko, Galyna; Bezditko, Tetyana; DuBuske, Lawrence
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    Case history (Medical database outline & Clinical Case)
    (2018) Ospanova, Tatyana; Bezditko, Tetyana; Avdeyeva, Olena; Bolokadze, Ievgenia; Borzenko, Alla
    Manual for practical lessons for students having higher Medical education in English.A capture of clinical inspection of patient skills is the major aim of preparation of student - physician. The student of 2 - 3 courses has first in life all-round to inspect a patient, to distinguish a diagnostic search, leading syndromes, to give a clinical diagnosis. Farther it will be necessary to ground and appoint treatment, define a prognosis.
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    Co-Morbidity of Asthma and Type 2 Diabetes Mellitus
    (2022-06) Yeryomenko, Galyna; Bezditko, Tetyana; Dubuske, Lawrence
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    Correction of metabolic acidosis in patients with asthma
    (2023-12) Yeryomenko, Galyna; Bezditko, Tetyana; Lawrence, DuBuske
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    CXCL1 Levels as a Biomarker of Systemic Inflammation in Severe Asthma
    (2021-02) Bezditko, Tetyana; Yeryomenko, Galyna; Dubuske, Lawrence
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    Endothelial Dysfunction in Patients having Asthma with Diabetes Mellitus Type 2 and Obesity
    (2020) Bezditko, Tetyana; Yeryomenko, Galyna; Dubuske, Lawrence
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    Features of molecular diagnostics in patients with asthma and allergic rhinitis
    (2019-06) Бездітко, Тетяна Василівна; Єрьоменко, Галина Володимирівна; Юрьев, Сергій Дмитрович; Yerymenko, G.; Bezditko, Tetyana; Yuriev, S.
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    Features of the endothelium in patients with asthma and type 2 diabetes mallitus.
    (2021-07) Bezditko, Tetyana; Yeryomenko, Galyna
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    Features of wheat allergen sensitization in type 2 diabetics with asthma
    (2021-07) Bezditko, Tetyana; Yeryomenko, Galyna; Dubuske, Lawrence
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    Microbiocenosis of the bronchial tree in asthma patients with type 2 diabetes mellitus
    (2022-02) Yeryomenko, Galyna; Bezditko, Tetyana; Dubuske, Lawrence
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    Peculiaritis of metabolic changes in asthma
    (2020-10) Bezditko, Tetyana; Yeryomenko, Galyna; Vysotska, Olene; Rysovana, Liubov; Pecherska, Anna
    Introduction. The numbers of patients having asthma (As) and As with metabolic syndrome (MS) keep steadily growing. The aim: revealing of clinical-pathogenetic peculiarities in manifestations of uncontrolled As+MS. Materials and methods. Sixty-five cases, divided into 2 groups: Group I – severe As (n=20), Group 2 – severe As+MS (n=45). The general clinical examination included fasting blood glucose, insulin level, HOMA-IR index, body mass index (BMI), spirometry, levels of ММР-9, МСР-1, IL-8 and IL-12. Results. In Group I, 20 patients (100%) had obstructive respiratory dysfunction. Group II had 13 cases (28.88%) with the restrictive, 15 (33.33%) with the obstructive and 17 (37.77%) with the mixed types. BMI revealed: Group I had the normal mass (BMI averaged 24.62 [22.76; 25.71]; Group II had 21 overweighed cases (46.66%) and 24 (53.33%) with grade 1 obesity, averaging 29.70 [28.35; 31.23]. Correlation analysis in Group II showed significant correlations between: age and WHR (r=0.52, p<0.001) (increase of abdominal fat depots during life), FEV1 and BMI (r=-0.63, р<0.001) (obesity affects pulmonary function). IL-8 and IL-12 levels in Group II were increased, respectively, by 27.86 and 13.18 times versus Group I. A relationship was found between MCP-1 and MMP-9 (r=0.77, р<0.05), Group II revealed direct correlation between MCP-1 and total FEV1 (r=0.53, р<0.05). Conclusions. Overweight and obesity in As+MS deteriorate respiratory function versus the same indices in isolated As. Relationships between proinflammatory cytokines and MMP-9 and MCP-1 prove pathogenetic peculiarities of systemic inflammation and metabolic homeostasis. As and MS can cause their coexistence, facilitating development of mutual aggravation.
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    Peculiaritis of metabolic changes in asthma
    (2020-10) Bezditko, Tetyana; Yeryomenko, Galyna; Vysotska, Olene; Rysovana, Liubov; Pecherska, Anna
    Introduction. The numbers of patients having asthma (As) and As with metabolic syndrome (MS) keep steadily growing. The aim: revealing of clinical-pathogenetic peculiarities in manifestations of uncontrolled As+MS. Materials and methods. Sixty-five cases, divided into 2 groups: Group I – severe As (n=20), Group 2 – severe As+MS (n=45). The general clinical examination included fasting blood glucose, insulin level, HOMA-IR index, body mass index (BMI), spirometry, levels of ММР-9, МСР-1, IL-8 and IL-12. Results. In Group I, 20 patients (100%) had obstructive respiratory dysfunction. Group II had 13 cases (28.88%) with the restrictive, 15 (33.33%) with the obstructive and 17 (37.77%) with the mixed types. BMI revealed: Group I had the normal mass (BMI averaged 24.62 [22.76; 25.71]; Group II had 21 overweighed cases (46.66%) and 24 (53.33%) with grade 1 obesity, averaging 29.70 [28.35; 31.23]. Correlation analysis in Group II showed significant correlations between: age and WHR (r=0.52, p<0.001) (increase of abdominal fat depots during life), FEV1 and BMI (r=-0.63, р<0.001) (obesity affects pulmonary function). IL-8 and IL-12 levels in Group II were increased, respectively, by 27.86 and 13.18 times versus Group I. A relationship was found between MCP-1 and MMP-9 (r=0.77, р<0.05), Group II revealed direct correlation between MCP-1 and total FEV1 (r=0.53, р<0.05). Conclusions. Overweight and obesity in As+MS deteriorate respiratory function versus the same indices in isolated As. Relationships between proinflammatory cytokines and MMP-9 and MCP-1 prove pathogenetic peculiarities of systemic inflammation and metabolic homeostasis. As and MS can cause their coexistence, facilitating development of mutual aggravation.
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    Peculiaritis of metabolic changes in asthma
    (2020-10) Bezditko, Tetyana; Yeryomenko, Galyna; Vysotska, Olene; Rysovana, Liubov; Pecherska, Anna
    Introduction. The numbers of patients having asthma (As) and As with metabolic syndrome (MS) keep steadily growing. The aim: revealing of clinical-pathogenetic peculiarities in manifestations of uncontrolled As+MS. Materials and methods. Sixty-five cases, divided into 2 groups: Group I – severe As (n=20), Group 2 – severe As+MS (n=45). The general clinical examination included fasting blood glucose, insulin level, HOMA-IR index, body mass index (BMI), spirometry, levels of ММР-9, МСР-1, IL-8 and IL-12. Results. In Group I, 20 patients (100%) had obstructive respiratory dysfunction. Group II had 13 cases (28.88%) with the restrictive, 15 (33.33%) with the obstructive and 17 (37.77%) with the mixed types. BMI revealed: Group I had the normal mass (BMI averaged 24.62 [22.76; 25.71]; Group II had 21 overweighed cases (46.66%) and 24 (53.33%) with grade 1 obesity, averaging 29.70 [28.35; 31.23]. Correlation analysis in Group II showed significant correlations between: age and WHR (r=0.52, p<0.001) (increase of abdominal fat depots during life), FEV1 and BMI (r=-0.63, р<0.001) (obesity affects pulmonary function). IL-8 and IL-12 levels in Group II were increased, respectively, by 27.86 and 13.18 times versus Group I. A relationship was found between MCP-1 and MMP-9 (r=0.77, р<0.05), Group II revealed direct correlation between MCP-1 and total FEV1 (r=0.53, р<0.05). Conclusions. Overweight and obesity in As+MS deteriorate respiratory function versus the same indices in isolated As. Relationships between proinflammatory cytokines and MMP-9 and MCP-1 prove pathogenetic peculiarities of systemic inflammation and metabolic homeostasis. As and MS can cause their coexistence, facilitating development of mutual aggravation.
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    State of humoral immunity in patients with asthma combined with obesity
    (2017) Yeryomenko, G.; Khimich, Tetyana; Bolokadze, Ievgenia; Mizhiritskaya, T.; Bezditko, Tetyana; Ospanova, T.
    It was found out in patients having asthma combined with obesity that in cases of a higher body mass index versus patients with asthma and healthy persons the “waist/hip volume” ratio was reliably increased. An examination of the state of humoral immunity indices in patients with asthma found out an increase of non-specific (with rising concentrations of immunoglobulins Ig A, M, G) and specific (with a rising level of Ig E) immunity. Patients with comorbidity of asthma and obesity revealed differently directed changes in the concentration of the main immunoglobulins: with a decrease in the levels of IgA and IgM there was a significant increase in the concentration of IgG. Those changes were accompanied by a significant reduction in the number of circulating immune complexes and an increasing concentration of lymphocyte antibodies in the blood of patients with comorbidity of asthma and obesity. This fact may indicate an aggravating effect of obesity on the course of asthma and a change in the direction of the pathological process to the autoimmune one that should be taken into consideration when treating such patients.
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    The treatment of patients with asthma and comorbidity
    (2018-03) Bezditko, Tetyana; Yeryomenko, Galyna
    The increasing prevalence of asthma (A) and diabetes mellitus type 2 (DM2T) necessitates administration of the adequate antiasthmatic long-term basic therapy with consideration of comorbid states. The purpose consisted in revealing the therapeutic potential of Tiotropium bromide (TB) and L-arginine (Tivortine) in patients having uncontrolled moderately severe asthma in combination with DM2T (A+DM2T). Forty seven A+DM2T patients underwent an in-depth study before and after their treatment. They were divided into 2 groups: treatment (group 1, n=28) and comparison (group 2, n=19). Both groups received the standard 2-component therapy: budesonide/formoterol fumarate dihydrate – 160/4.5μg by 2 breaths twice a day and metformin at a dose of 500 mg twice a day. The complex of their basic therapy for group 1 additionally included TB (18 μg a day) and arginine hydrochloride preparation (Tivortine® aspartate, Yuriya-Farm) orally by 15 ml twice a day during 3 months (90 days). The patients were followed up 3 months and one year later. Their general condition demonstrated positive dynamics in both groups, the number of exacerbations in group 1 reducing by a factor of 4. The complex use of L-arginine and TB preparations against a background of the basic therapy in A+DM2T patients produced a better control over the disease, a more rapid elimination of obstruction manifestations, achievement and prolongation of the clinical spirographic remission, an improvement of the quality of life, correction of disturbances in haemocoagulation, fibrinolysis and the functional state of endothelium.
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