Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/32578
Title: | Renin-angiotensin system: a review of historical perspectives |
Authors: | Kovalyova, Olga Ковальова, Ольга Миколаїівна Zhuravlyova, Anna Журавльова, Анна Костянтинівна Ivanchenko, Svitlana Іванченко, Світлана Володимирівна |
Keywords: | renin-angiotensin system angiotensin-converting enzyme angiotensin mas receptor 2023а |
Issue Date: | 2023 |
Publisher: | Івано-Франківський національний медичний університет |
Citation: | Kovalyova O. Renin-angiotensin system: a review of historical perspectives / O. Kovalyova, A. Zhuravlyova, S. Ivanchenko // Galician Medical Journal. – 2023. – № 30 (2). – P. 1–10. |
Abstract: | The article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the subsequent discoveries of angiotensin-converting enzyme 2, angiotensin-(1-7), Mas receptor. This paper presents a modern classification of the renin-angiotensin system, dividing it into classical and non-classical branches, based on the determination of the biological effects of its components. Significant attention is devoted to elucidating the biochemical cascade of the renin-angiotensin system, its physiological transformations, and its implications in human body processes. The detrimental cardiac effects of the classical renin-angiotensin system are highlighted, along with the crucial role played by its alternative axis in counteracting the development of cardiovascular diseases. The article presents data on the involvement of angiotensin-converting enzyme 2 and its receptors in coronavirus infections, susceptibility to infection, and disease progression. |
URI: | http://repo.knmu.edu.ua/handle/123456789/32578 |
Appears in Collections: | Наукові праці. Кафедра загальної практики – сімейної медицини та внутрішніх хвороб |
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Галицкий медичний вісник.pdf | 910,14 kB | Adobe PDF | View/Open |
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