Grade of arterial hypertension severety in patients with 2 type diabetes mellitus and its interaction with adypocitokine mediators, carbohydrate and lipid metabolism

Abstract

The study describes the dynamics of parameters of carbohydrate and lipid metabolism, together with the activity of adipocytokine mediators, namely apelin-12 and obestatin, in patients with type 2 diabetes depending on the severity of arterial hypertension. In patients with arterial hypertension in combination with type 2 diabetes, there are synergistic attempts of apelin-12 and obestatin for normalizing blood pressure level, however, the concentration of these markers is inadequate for existing needs. The discrepancy between the levels of apelin-12 and obestatin in the activity of the renin-angiotensin-aldosterone system is accompanied by an increase in blood pressure of more than 180/100 mm Hg. in patients with type 2 diabetes mellitus.