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http://repo.knmu.edu.ua/handle/123456789/30638
Title: | Triple-negative breast cancer: current treatment strategies and factors of negative prognosis |
Authors: | Baranova, Anna Krasnoselskyi, Mykola Starikov, Volodymyr Kartashov, Sergii Zhulkevych, Igor Vlasenko, Vadym Oleshko, Kateryna Bilodid, Olga Sadchikova, Marina Vinnyk, Yurii |
Keywords: | breast cancer triple-negative type surgical treatment radical mastectomy organ-preserving operations late result |
Issue Date: | 2-Feb-2022 |
Citation: | Triple-negative breast cancer: current treatment strategies and factors of negative prognosis / A. Baranova, M. Krasnoselskyi, V. Starikov, S. Kartashov, I. Zhulkevych, V. Vlasenko, K. Oleshko, O. Bilodid, M. Sadchikova, Y. Vinnyk // Journal of medicine and life. – 2022. – Vol. 15 (2). – P. 153–161. |
Abstract: | Breast cancer is the most common cancer in women and the most common cause of death in working-age women. According to the results of immunohistochemical studies, 10–20% of cases revealed a triple-negative type of breast cancer. This subtype is characterized by significant proliferative activity and growth rate, aggressive clinical course, and early metastasis. This leads to a suspicious prognosis and, accordingly, encourages an increase of surgical treatment radicalism and aggressive systemic treatment. This review briefly analyzes existing treatment strategies for triple-negative breast cancer with a focus on surgical treatment. Surgical treatment is an integral part of complex therapy. Currently, the attention of researchers is focused not only on the radicalism of the operation, ensuring long-term survival, but also on achieving a good cosmetic result that determines the quality of life of patients. In this aspect, organ-preserving and prosthetic methods of operations are promising, the feasibility and effectiveness of which are being discussed. The relevance of choosing the optimal method of operation is evidenced by the lack of generally accepted approaches based on informative markers for the prognosis of the course of the disease. Therefore, the choice of the optimal method of surgical treatment taking into account the individual characteristics of the patient and the tumor, indications for chemotherapy, and radiation therapy remains an unresolved issue and requires further research. |
URI: | https://repo.knmu.edu.ua/handle/123456789/30638 |
Appears in Collections: | Наукові праці. Кафедра онкології |
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Статья Барановой СКОПУС.pdf | Triple-negative breast cancer: current treatment strategies and factors of negative prognosis | 226,3 kB | Adobe PDF | View/Open |
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