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DC Field | Value | Language |
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dc.contributor.author | Vodolazhenko, Mariya | - |
dc.contributor.author | Mykhailenko, Anastasia | - |
dc.contributor.author | Gorobets, Nikolay | - |
dc.contributor.author | Desenko, Sergey | - |
dc.date.accessioned | 2018-03-19T13:07:39Z | - |
dc.date.available | 2018-03-19T13:07:39Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Two-stage one-pot interaction of acyclic β-ketoesters, DMFDMA and 2-cyanomethylbenzimidazole / M. A. Vodolazhenko, A. E. Mykhailenko, N. Yu. Gorobets, S. M. Desenko // Вісник Харківського національного університету. Серія Хімія. – 2017. – Вип. 29 (52). – Р. 31–45. | ru_RU |
dc.identifier.uri | https://repo.knmu.edu.ua/handle/123456789/19212 | - |
dc.description.abstract | A one-pot two-stage interaction of acyclic β-ketoesters, dimethylformamide dimethylacetal (DMFDMA) and 2-cyanomethylbenzimidazole was studied. Carried out under microwave irradiation in 2-propanol in the presence of piperidine, this transformation leads to the formation of 4-cyanobenzo[4,5]imidazo [1,2-α]pyridine-2-carboxylates, whereas at room temperature in methanol in the presence of sodium methylate 1-hydroxybenzo[4,5]imidazo[1,2-α]pyridine-4-carbonitriles are formed. Intermediate enamines initially formed from β-ketoesters and DMFDMA attack methylene group of 2-cyanomethylbenzimidazole followed by heterocyclizaton. In the presence of piperidine the benzimidazole nitrogen atom attacks the keto group of the β-ketoester fragment, whereas in the strong basic conditions cyclization occurs by the ester group. | ru_RU |
dc.language.iso | en | ru_RU |
dc.publisher | ХНУ імені В.Н.Каразіна | ru_RU |
dc.subject | β-ketoester | ru_RU |
dc.subject | 2-cyanomethylbenzimidazole | ru_RU |
dc.subject | one-pot heterocyclization | ru_RU |
dc.subject | DMFDMA | ru_RU |
dc.subject | microwave irradiation | ru_RU |
dc.title | Two-stage one-pot interaction of acyclic β-ketoesters, DMFDMA and 2-cyanomethylbenzimidazole | ru_RU |
dc.type | Article | ru_RU |
Appears in Collections: | Наукові праці. Кафедра медичної та біоорганічної хімії |
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File | Description | Size | Format | |
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Two-stage one-pot interaction of acyclic β-ketoesters.pdf | 707,87 kB | Adobe PDF | View/Open |
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