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DC Field | Value | Language |
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dc.contributor.author | Kuzhko, Mykhailo | - |
dc.contributor.author | Gumeniuk, Mykola | - |
dc.contributor.author | Butov, Dmytro | - |
dc.contributor.author | Tlustova, Tetiana | - |
dc.contributor.author | Denysov, Oleksii | - |
dc.contributor.author | Sprynsian, Tetiana | - |
dc.date.accessioned | 2017-11-29T14:03:08Z | - |
dc.date.available | 2017-11-29T14:03:08Z | - |
dc.date.issued | 2017-01-14 | - |
dc.identifier.citation | The effectiveness of treatment in patients with destructive pulmonary tuberculosis depending on the mode of administration of antimtuberculosis drugs / M. Kuzhko, M. Gumenyuk, D. Butov, T. Tlustova, O. Avramchuk, O. Denysov, T. Sprynsian // New Developments in Our Basic Understanding of Tuberculosis : Keystone Symposia on Molecular and Cellular Biology, Vancouver, Canada, 14–18 January 2017. – Vancouver, 2017. – P. 111. | ru_RU |
dc.identifier.uri | https://repo.knmu.edu.ua/handle/123456789/18402 | - |
dc.description.abstract | Background and objective. The aim of research was to determine the effectiveness of chemotherapy using intravenous (i/v) antimtuberculosis drugs compared with their oral administration during the intensive phase (IP) of treatment in patients with destructive pulmonary tuberculosis (TB). Methods. 130 TB patients were randomized into 2 groups: Main (n=65) who received isoniazid, ethambutol and sodium rifamycin i/v + pyrazinamide per os and control (n=65) who received all the drugs (isoniazid, rifampicin, ethambutol, pyrazinamide) orally. Results. After 2 weeks of treatment symptoms of intoxication disappeared in 90.7% of patients of the main group (MG) and 75.0% patients in the control group (CG), p<0.05. The mean duration of symptoms of intoxication in patients MG was 9,6±0,7 days, in CG -13.4±1.2 days. After completing IP sputum conversion was found in all the patients MG and 43 (95.7%) patients CG. The average time of sputum conversion in MG was 1.6±0.1 months and 1.8±0.1 months in CG, p>0.05. In patients with destructive pulmonary TB time to sputum conversion was 1.7±0.1 months in MG and 2.1±0.1 months in CG, p<0.05. The average time of cavities healing in MG was 2.9±0.2 months and 3.7±0.3 months in the CG, p<0.05. Conclusions. In patients with destructive pulmonary TB use of isoniazid, ethambutol and sodium rifamycin i/v in the intensive phase of chemotherapy resulted in a significant reduction in terms of the disappearance of symptoms of intoxication and sputum conversion. Funding acknowledgement: the study was supported by the National Academy of Medical Sciences of Ukraine. | ru_RU |
dc.language.iso | en | ru_RU |
dc.subject | antimtuberculosis drugs | ru_RU |
dc.subject | tuberculosis | ru_RU |
dc.title | The effectiveness of treatment in patients with destructive pulmonary tuberculosis depending on the mode of administration of antimtuberculosis drugs | ru_RU |
dc.type | Thesis | ru_RU |
Appears in Collections: | Наукові роботи молодих вчених. Кафедра фтизіатрії та пульмонології |
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