Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/7424
Title: | Distant apoptosis markers in human hypertension |
Authors: | Ashcheulova, Tetyana Ащеулова, Тетяна Вадимівна Ащеулова, Татьяна Вадимовна Kovalyova, Olga |
Keywords: | apoptosis circulating apoptosis biomarkers arterial hypertension |
Issue Date: | 2014 |
Citation: | Ashcheulova T. Distant apoptosis markers in human hypertension / T. Ashcheulova, O. Kovalyova // Inter Collegas. – 2014. – Vol. 1, N 1. – P. 31–42. |
Abstract: | DISTANT APOPTOSIS BIOMARKERS IN HUMAN HYPERTENSION Ashcheulova T, Kovalyova O. The aim was to study plasma apoptosis markers (TNF-α, sTNF-R1, sFasL) levels in patients with arterial hypertension (AH) depend on degree of blood pressure elevation. We examined 78 patients with AH, which were divided into 3 groups depend on AH degree: 1 group (n=18) – 1 degree AH, 2 group (n=25) – 2 degree AH, 3 group (n=35) – 3 degree AH. Plasma tumor necrosis factor-α (TNF-α), soluble TNF receptors type 1 (sTNF-R1), and soluble Fas ligand (sFasL) levels by ELISA were detected. It was found that plasma TNF-α levels in all groups patients were higher than in healthy normotensives (p<0.05). Maximum mean was detected in 2 degree AH patients. Circulating sTNF-R1 levels of all groups patients were elevated vs normal means (p<0.05). In spite of detected increasing sTNF-R1 concentration, natural TNF-α inhibitor, and insignificant decreasing of TNF-α/sTNF-R1, cytokine level remained high, that confirm possibility of TNF-mediated apoptosis pathway in hypertensive patients. Obtained results indicate possibility of Fas-related apoptosis in patients with arterial hypertension. Conclusion. Result of our clinical study showed increased immuno-inflammatory and proapoptotic activity depends on presence and degree of arterial hypertension. |
URI: | https://repo.knmu.edu.ua/handle/123456789/7424 |
Appears in Collections: | Наукові праці. Кафедра пропедевтики внутрішньої медицини № 1, основ біоетики та біобезпеки |
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