Creation of new drug compositions and pharmacological substantiation of their suitability for pain syndromes and inflammations in experimental rats

Abstract

Creation of combined drugs whose pharmacological effects are due to the rational combination of ingredients is the urgent problem of modern medicine. Combination of several components in one drug expands its pharmacological range and promotes polytropic activity. The advantage of combined drugs compared with pure drugs is that they more effectively eliminate pain and inflammation than each individual component. Combined analgesics often include caffeine. According to literature data caffeine enhances analgesic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) and nonnarcotic analgesics (NNA). However, there are no data on the composition of diclofenac sodium (D-Na), ibuprofen (Ib) with caffeine in the literature. This fact caused experimental studies of influence of caffeine on the analgesic and anti-exudative effects of D-Na and Ib. Experimental studies have been conducted on laboratory animals (white adult rats of the WAG strain) by intragastric administration. Analysis of experimental results clearly indicates that caffeine potentiates analgesic and anti-exudative effects of D-Na and Ib. Thus, compositions of D-Na and Ib with caffeine were experimentally studied for the first time. Suitability of compositions is proved and application in inflammation and pain of various origins is demonstrated. Results can serve as foundation for development of new domestic combined drugs with analgesic and anti-inflammatory effects.