The influence of treatment tactics on the level of quality of life and the condition of the nasal cavity in patients with chronic atrophic rhinitis provoked by harmful production conditions

Abstract

Introduction. Various types of occupational hazards can cause the development of occupational atrophic rhinitis (AR). Researches determine the high prevalence of professional AR among workers in various fields of production. Drug treatment of RA is an important issue. The effectiveness of the use of autologous platelet- enriched plasma is determined. Determining the possibilities of increasing the effectiveness of treatment of professional AR with platelet- enriched plasma is a very relevant issue of modern medicine. The aim. To evaluate the use of autologous platelet-rich plasma in occupational chronic AR compared to standard treatment (irrigation with oil solutions). Materials and methods. 141 patients were examined: I group (32.6 %) received irrigation with oil solutions, II (39.7 %) – injections of platelet-rich plasma, and III (27.7 %) – injections of platelet-rich plasma and irrigation with oil solutions. Results. Significant (p < 0.001) chances of improvement in quality of life levels were found in groups I and II compared to III one month after treatment, based on decreases in the values of the NOSE scale (respectively by 0.946 points and by 5.285 points) and increases values in the SF-36 questionnaire (RE scale and RR by 13.899 points; p = 0.004 and by 15.914 points only with combined treatment; MH scale – by 4.028 points and by 17.880 points; VT scale – by 5.136 points; p = 0.005 and by 24.158 points). Significant (p < 0.001) chances of an increase in nasocytogram indicators were determined in groups I and II compared to III: respectively, the pH of mucus (by 1.029 and by 1.333), the quantitative composition of neutrophils (by 18.958 % and by 21.078 %) and eosinophils (by 3.540 %) combined treatment only) and saccharin test indicators (at 0.3 min; p = 0.005 and at 1.696 min). Conclusions. An improvement in the quality of life and parameters of the nasocytogram and saccharin test was determined when injections of platelet-rich plasma were used (both separately and in combination with irrigation with oil solutions) in patients with occupational chronic AR. Reliable chances of a decrease in NOSE scale values and an increase in SF-36 questionnaire indicators and chances of an increase in nasocytogram and saccharin test indicators were established.