Differences in cystatin C level depending on parameters of daily blood pressure monitoring in patients with essential hypertension and frequent extrasystoles

Abstract

156 patients with stage II essential hypertension were examined, among them, 124 had frequentsymptomatic extrasystole and 32 patients did not have any heart rhythm disorders. Another 30 healthy persons were included in the control group. Complete clinical, laboratory and instrumental examinations were applied to all study participants, including daily blood pressure monitoring and cystatin C serum concentration. It was found that the level of cystatin C was significantly higher in hypertensive patients compared to controls (р<0.001). In turn, in the presence of extrasystoles, the mean cystatin C was significantly higher than in patients without extrasystoles (p<0.05). The highest level of cystatin C was noticed in patients with essential hypertension and ventricular extrasystole. It was significantly different from the patients with extrasystole of supraventricular origin (p<0.05) and patients without arrhythmias (p<0.001) or healthy individuals (p<0.001). Also, higher values of blood pressure and a relatively high level ofserum cystatin C were found in patients with hypertension, which allows us to suspect the common pathophysiological mechanisms of an increase in the cystatin C level, values of blood pressure and the occurrence of frequent extrasystoles (especially of the ventricular origin).