Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/32070
Title: | Tocilizumab is effective in preventing ovarian injury induced by ischemia- reperfusion in rats |
Authors: | Uzel, Kemine Lakhno, Igor Turkler, Can Kuzucu, Mehmet Naz, Gulce Yazici Mammadov, Renad Suleyman, Bahadir Ahadir Kale, Ahmet Suleyman, Halis |
Keywords: | interleukin-6 ovarian torsion reperfusion injury surgery tocilizumab |
Issue Date: | 15-May-2023 |
Publisher: | Academia Brasileira de Ciências |
Citation: | Tocilizumab is effective in preventing ovarian injury induced by ischemia- reperfusion in rats / K. Uzel, I. Lakhno, C. Turkler, M. Kuzucu, G. Y. Naz, R. Mammadov, A. Kale, H. Suleyman // An Acad Bras Cienc. – 2023. – Vol. 95, No 1. – e20220442. – DOI: 10.1590/0001-3765202320220442. |
Abstract: | Ovarian torsion can be defined as the bending of the ovaries on the supporting ligament, disrupting both venous and arterial blood circulation. Insufficient blood flow causes ovarian tissue hypoxia and leads to ischemia. This study aimed to investigate whether tocilizumab has a protective effect on ischemia-reperfusion injury due to ovarian torsion in rats. Eighteen female Wistar albino rats were divided into three equal groups (Sham (SG), ischemia-reperfusion (OIR), and ischemia-reperfusion+tocilizumab (OIRT)). Degeneration, necrosis, vascular dilatation/congestion, interstitial edema, hemorrhage, and polymorphonuclear lymphocyte (PMNL) infiltration scores were significantly different between the groups (p=0.001 for all parameters). Moreover, the OIRT group had a significant improvement in these criteria compared to the OIR group (p<0.05). Additionally, there was a considerable difference between OIRT and OIR groups in the number of primordial, developing, and atretic follicles groups (p<0.05), while there was no difference in the number of corpus luteum (p=0.052). Stress markers or cytokines, such as MDA, tGSH, NF-κB, TNF-α, IL-1β, and IL-6, were significantly different between groups (p<0.05). Furthermore, a significant improvement was found in the measured variables when the OIRT group was compared with the OIR group (p<0.05). Tocilizumab may be an alternative option for treating ischemia-reperfusion injury due to ovarian torsion. |
URI: | http://repo.knmu.edu.ua/handle/123456789/32070 |
Appears in Collections: | Наукові праці. Кафедра акушерства та гінекології № 3 |
Files in This Item:
File | Description | Size | Format | |
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mTMxdYCwZWNqfj7V7fv53wQ.pdf | 2,08 MB | Adobe PDF | View/Open |
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