Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/31494
Title: | Bacterial vaginosis and HPV-related cervical lesions |
Authors: | Muryzina, Iryna Kucheryna, Natalia Bilodid, Olga Ushkalova, Anna Alieksieieva, Viktoria |
Keywords: | vaginosis Cervical cancer Human papillomavirus |
Issue Date: | 2022 |
Citation: | Bacterial vaginosis and HPV-related cervical lesions / I. Muryzina, N. Kucheryna, O. Bilodid, A. Ushkalova, V. Alieksieieva. // International Journal of Gynecological Cancer. – 2022. – Vol. 32. – P. 389. |
Abstract: | Shift in the vaginal microbiotafrom the predominant Lactobacillus spp. to the abundance of anaerobic bacteria is quite common among women of reproductive ages,approximately 40–80% of them report no complaints. However bacterial vaginosis (BV) is strongly associated with increased host susceptibility to STI (hrHPV included). Gardnerella Vaginalis (GV) might pave the way for STI causing epithelial cell (EC) damage and shedding, suppressing leukocyte recruitment, thereby leaving underlying mucosal tissue exposed to potential pathogens. Pushing regrowth of EC layers GV may make HPV-infected EC liable for persistent HPV dwelling there and than trigger viral DNA incorporation into host genome and launch neoplastic transformation. GV is a powerful biofilm-producer therefore BV often remains recalcitrant to treatment. Another input to recurrent BV can be made by host genetic variation in stress-related genes and smoking.The study examined the rate of BV among HPV-infected women with LSIL and HSIL (separately). |
URI: | http://repo.knmu.edu.ua/handle/123456789/31494 |
Appears in Collections: | Наукові праці. Кафедра оториноларингології |
Files in This Item:
File | Description | Size | Format | |
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A389.2.full.pdf | 59,17 kB | Adobe PDF | View/Open |
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