Вплив оксиетильованих нонілфенолів та їх похідних на стан неспецифічної імунної резистентності щурів

Abstract

Pollution of the biosphere by such ionogenic surface-active chemical compounds as oxyethylated nonylphenols (OENP) and their derivates – sodium salts of carboxymethylates of oxyethylated isononylphenols (CMOENP) has the harmful effect first of all on the immune, endocrine and central nervous systems resulting in wide spectrum of functional disorders. The mechanisms of OENP biological effects are unstudied, although their lightening is hoped to be a relevant ground for assessment and regulation of their permissible concentration in the environment and health care prophylactics. The aim of the research was to assess the prolonged peroral influence of OENP with number of oxymethylated groups 4, 10 and 12 (OENP4-12) and CM-OENP with number of oxymethylated groups 4, 5 and 6 (CM-OENP4-6) in concentrations 1/10 and 1/100 LD50 (lethal dose 50) on nonspecific immune resistance changes in rats. The leukocytes differential count, phagocytic activity as well as proteins of acute phase (PAP) and lysozyme concentrations were studied. It was observed that longterm intoxication with OENP and CM-OENP in studied doses had an impact on nonspecific immune resistance that is revealed by affected leukogram, diminished phagocytic activity of neutrophil leukocytes, reduced concentrations of haptoglobin, ceruloplasmin, fibrinogen and lysozyme.