Immune aspects of right heart remodeling in chronic obstructive pulmonary disease and arterial hypertension

Abstract

Introduction. Patients with chronic obstructive pulmonary disease (COPD) are at high risk of right heart remodeling. Deterioration of collagen metabolism plays an important role in the formation and progression of right heart failure. Uncontrolled synthesis and accumulation of collagen in the interstitium of the myocardium and blood vessels leads to the increase of their hardness and remodeling. Despite the association of antibodies to type IV collagen with bronchial and cardiovascular risk, their role remains unclear in combined cardio-pulmonal pathology, namely COPD and arterial hypertension (AH). The aim of the study: examination whether autoantibodies against native or aldehyde-modified collagen are associated with right heart remodeling in arterial hypertension combined with chronic obstructive pulmonary disease. Conclusions. Correlation of the levels of type IV collagen antibodies with cardiac morphofunctional parameters indicate of their pathogenetic importance in the development of myocardial dysfunction and may be used in the diagnosis, control of the course and prognosis of right heart remodeling in COPD and AH.