Interleukins 33 and 1β, left ventricular geometry and diastolic dysfunction in hypertensive patients with obesity

Abstract

Purpose: To investigate interrelations between interleukin 33 (IL-33) and 1β (IL-1β) serum levels, left ventricular (LV) remodeling and diastolic dysfunction (DD) in hypertensive patients with obesity. Materials and methods: 80 hypertensive patients (51 obese) underwent transthoracic echocardiography. LV geometric pattern by A.Ganau, E/A and E/E' ratios, pulmonary wedge pressure (PWP) by S.Nagueh were calculated. IL-33 and IL-1β serum levels were estimated using ELISA. Results: IL-33 and IL-1β were higher in hypertensive patients (p<0,001), independently of BMI, and formed 4 clusters (see pic.) Cluster 1 was associated with the highest LV myocardial mass index (MMI) (160,5 (142,8; 185,8) g/m2, p<0,05), highest prevalence of LV hypertrophy (LVH) (100,0%, 90,0% of concentric LVH), moderate decrease in E' velocity (9,95 (8,32; 10,60) cm/sec), relatively low PWP (9,23 (8,83; 13,03) mmHg) and 70,0% prevalence of LVDD (60,0% of type I). Cluster 2 had LVMMI of (116,9 (104,4; 163,1) g/m2), 55,0% prevalence of LVH plus 30,0% of concentric remodeling, lowest E' (7,68 (6,50; 9,67) cm/sec, p<0,01), highest PWP (12,26 (10,72; 13,12) mmHg, p<0,05) and highest rate of DD (85,0%, 70,0% of type I). Cluster 4 was associated with MMI of 121,4 (111,7; 140,5) g/m2, 66,7% rate of LVH (equal for concentric and eccentric variants), highest values of E' (11,04 (9,49; 12,00) cm/sec), lowest PWP (9,07 (7,04; 11,51) mmHg) and lowest prevalence of LVDD (66,7%, 50,0% of type I). Cluster 3 (p>0,05 vs control group) had intermediate characteristics of mentioned parameters. Conclusion: Significant increase in IL-33 and IL-1β levels in hypertensive patients independently of BMI was revealed. Increase in both cytokines' levels was associated with highest rates of LVH and DD. Prevalent increase in IL-1β was connected to the worst state of diastolic function despite low rates of hypertrophy. Prevalent increase in IL-33 had the most favorable influence on the severity of LVH as well as diastolic filling (figure above).

Description

Citation

Honchar O. Interleukins 33 and 1β, left ventricular geometry and diastolic dysfunction in hypertensive patients with obesity / O. Honchar // Archives of Cardiovascular Diseases. – 2015. – Vol. 7, N 1, Suppl. XXV Journees Europeennes de la Societe Francaise de Cardiologie, Paris, France, 14–17 January, 2015. – P. 81.

Endorsement

Review

Supplemented By

Referenced By