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http://repo.knmu.edu.ua/handle/123456789/32627
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DC Field | Value | Language |
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dc.contributor.author | Gavrylov, Anatoliy | - |
dc.contributor.author | Tieroshyn, Vadym | - |
dc.contributor.author | Kartsonaki, C. | - |
dc.contributor.author | Baillie, J.K. | - |
dc.contributor.author | Barrio, N.G. | - |
dc.contributor.author | Zoufaly, A. | - |
dc.contributor.author | Zucman, D. | - |
dc.contributor.author | ISARIC Clinical Characterisation Group | - |
dc.date.accessioned | 2023-10-18T16:59:19Z | - |
dc.date.available | 2023-10-18T16:59:19Z | - |
dc.date.issued | 2023-02-28 | - |
dc.identifier.citation | Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19 / C. Kartsonaki, J. K. Baillie, N. G. Barrio [at al.] // International Journal of Epidemiology. ─ 2023. ─ Vol. 52, № 2. ─ P. 355–376. | en_US |
dc.identifier.uri | http://repo.knmu.edu.ua/handle/123456789/32627 | - |
dc.description.abstract | Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world’s largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a 30-fold difference between the oldest and youngest groups; each of the co-morbidities included wasassociated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death. | en_US |
dc.language.iso | en | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | cohort study | en_US |
dc.subject | risk of death | en_US |
dc.subject | co-morbidities | en_US |
dc.subject | symptoms | en_US |
dc.subject | treatments | en_US |
dc.subject | 2023а | en_US |
dc.title | Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19 | en_US |
dc.type | Article | en_US |
Appears in Collections: | Наукові праці. Кафедра дитячих інфекційних хвороб |
Files in This Item:
File | Description | Size | Format | |
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Epidemiology.pdf | 1,38 MB | Adobe PDF | View/Open |
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