Please use this identifier to cite or link to this item: http://repo.knmu.edu.ua/handle/123456789/32354
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dc.contributor.authorMykytenko, Andrii-
dc.contributor.authorAkimov, Oleg-
dc.contributor.authorYeroshenko, Galina-
dc.contributor.authorShevchenko, Oleksandr-
dc.contributor.authorNeporada, Karine-
dc.date.accessioned2023-06-27T05:49:50Z-
dc.date.available2023-06-27T05:49:50Z-
dc.date.issued2023-
dc.identifier.citationBiochemical changes in the extracellular matrix of rat liver during chronic alcohol intoxication / A. Mykytenko, O. Akimov, G. Yeroshenko, O. Shevchenko, K. Neporada // Світ медицини та біології. – 2022. – № 4 (82). – С. 221–225.en_US
dc.identifier.urihttp://repo.knmu.edu.ua/handle/123456789/32354-
dc.description.abstractExcessive alcohol consumption is a global health problem worldwide, resulting in more than 3 million deaths each year. The purpose of this work was to study the biochemical markers of intercellular matrix metabolism of rat liver under the conditions of chronic alcohol intoxication modeling. The experiments were performed on 30 male Wistar rats, weighing 180-220 g. The animals were divided into 2 groups: І – control; ІІ – chronic alcohol intoxication. Animals were removed from the experiment on days 10, 14, 21 and 28. We studied concentration of glycosaminoglycans, oxyproline and sialic acids in rat liver. We established that the greatest depolymerization of proteoglycans was on the 21st day, the highest intensity of collagenolysis was on the 14th day. Glycoproteins underwent the greatest catabolism on the 28th day. Chronic alcohol intoxication on the 28th day led to increased breakdown of glycoproteins and proteoglycans of the extracellular matrix of the liver, and increased the intensity of collagenolysis.en_US
dc.language.isoenen_US
dc.subjectalcoholen_US
dc.subjectliveren_US
dc.subjectglycosaminoglycansen_US
dc.subjectsialic acidsen_US
dc.subjectoxyprolineen_US
dc.subjectextracellular matrixen_US
dc.subjectалкогольen_US
dc.subjectпечінкаen_US
dc.subjectглікозаміногліканиen_US
dc.subjectсіалові кислотиen_US
dc.subjectпозаклітинний матриксen_US
dc.titleBiochemical changes in the extracellular matrix of rat liver during chronic alcohol intoxicationen_US
dc.title.alternativeпозаклітинний матриксen_US
dc.typeArticleen_US
Appears in Collections:Наукові праці. Кафедра загальної та клінічної патофізіології імені Д.О. Альперна



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