Influence of a hypocaloric diet on the parameters of nonspecific humoral immunity in rats

Abstract

Have been considered the role of the imbalance of regulatory cytokines in the blood in the implementation of immune responses in rats that were on a hypocaloric diet, compared with the control, where was established: a predominant increase in the content of IL-12, a decrease in IL-4 in rats, which indicates the participation of both specific (Th 1), and non-specific (macrophage), cellular immunity in the mechanisms of damage to the pancreas and the development of chronic pancreatitis in the future. The latter is probably associated with a violation of intercellular interaction due, first of all, to a decrease in the functional activity of macrophages - effector cells, modulators of the immune response, and sources of regulatory cytokines.