Features of formation and progression of chronic kidney disease in children with pyelonephritis and vesicoureteral reflux

Abstract

Vesicoureteral reflux (VUR) is observed in 40% of children with pyelonephritis and is one of the leading causes of its recurrent course, which subsequently leads to chronic kidney disease. The purpose of this study was to determine the peculiarities of the formation and progression of chronic kidney disease in children with pyelonephritis and vesicoureteral reflux. The clinical material from 141 children aged from 6 months to 17 years with grade I-V VUR in the period of clinical and laboratory remission of pyelonephritis was analyzed. The study showed that the risk of developing scarring of renal parenchyma in children with high-grade VUR was 8 times higher than in children with grade I-II VUR.