Human Red Blood Cell Properties and Sedimentation Rate: a Biomechanical Study
Date
2018-09-07
Authors
Kizilova, Nataliya
Batyuk, Liliya
Cherevko, Vitalina
Journal Title
Journal ISSN
Volume Title
Publisher
Springer International Publishing
Abstract
Human blood is widely used for clinical diagnostics due to its easy accessibility and high sensitivity for any metabolic disorders and diseases. In the paper different mechanical and electric properties of red blood cells (RBC) useful for diagnostics are discussed. The experimental data on the erythrocyte sedimentation rate (ESR) test in its standard procedure and continuous
computer assisted assessment are presented. The review of mathematical
approaches for reasonable ESR estimation is given. The continuous model of
blood as three phase suspension is used for numerical estimation of aggregate
ability of RBC. The problem on RBC aggregation and sedimentation in a thin
vertical tube is considered. A numerical solution of the formulated hyperbolic
problem is obtained by the method of characteristics. Numerical computations
have been carried out for a wide range of RBC parameters proper to healthy
state and patients with cancer, drug and food allergy. It is shown the continuous
sedimentation curves give more diagnostic information than the standard ESR
value. Based on the experimental and theoretical study, a biomechanical interpretation of the ESR curves is proposed.
Description
Keywords
red blood cells, biomechanics, electric potential, medical diagnostics, sedimentation rate
Citation
Kizilova N. Human Red Blood Cell Properties and Sedimentation Rate: a Biomechanical Study / N. Kizilova, L. Batyuk, V. Cherevko // Biomechanics in Medicine and Biology : Proceedings of the International Conference of the Polish Society of Biomechanics, Zielona Gora, Poland, September 5–7, 2018 / K. Arkusz, R. Bedzinski, T. Klekiel, S. Piszczatowski, eds. – 2019. – P. 3–22. – (Springer Series «Advances in Intelligent Systems and Computing», Vol.831). – DOI: doi.org/10.1007/978-3-319-97286-2_1.