Липиды и структурно-функциональное состояние миокарда при хронической обструктивной болезни лёгких
Date
2018
Authors
Оспанова, Татьяна Сунгашевна
Семидоцкая, Жанна Дмитриевна
Чернякова, Ингеборг Александровна
Пионова, Елена Николаевна
Трифонова, Наталия Сергеевна
Авдеева, Елена Викторовна
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The achievements of modern network science in the field of molecular biology, genome, and molecular
genetics made it possible to study the causes of comorbidity on the organism, molecular, genetic levels,
and to show the importance of cellular networks between these components. Using these advances has led to
the isolation of a particular group synthropic diseases. Chronic obstructive pulmonary disease is a classic example
of a comorbid disease characterized by a combination with coronary artery disease, arterial hypertension.
This causes the actuality of studying the problems of pathogenesis, comorbidity, synthropy of chronic obstructive
pulmonary disease.
The purpose of the study was to investigate the features of the lipid spectrum and echocardiography parameters
interrelationships in chronic obstructive pulmonary disease with coronary artery disease, arterial hypertension.
Material and methods. 35 patients with chronic obstructive pulmonary disease with comorbid pathology
(57.14% male, 42.86% female) were examined. The average age was 57.0, the middle duration of the disease
was 10.02 [5,0–15,0] years. Patients were divided into 3 groups: group B (12 patients), group C (14 patients),
group D (9 patients).
Results and discussion. We found 7 positive correlations with the parameters of the heart structuralfunctional
state. Analysis of echocardiography indices revealed changes in the parameters of both the right and
the left ventricle, more pronounced in the presence of comorbidity. The change in pulmonary blood flow leads to
the pressure increase in the pulmonary artery, a load on the right heart, an increase in structural and functional
changes in the right heart (more pronounced for comorbidity). The peculiarity of group D was a large number of
correlations. With the comorbidity of chronic obstructive pulmonary disease and arterial hypertension, the total
number of correlations remains. 5 correlations were revealed between the lipid spectrum and echocardiogramm:
total cholesterol and aortic diameter (R = 0.506), low-density lipoproteins and interventricular septum thickness,
aortic root diameter, right atrium (R = 0.445, 0.438, and 0.535, respectively).
Conclusions: There is a significant number of various correlation links between the parameters of the lipid
spectrum and the parameters of the myocardium structural-functional state. The number of correlations increases
with the progression of the severity of chronic obstructive pulmonary disease. The connection of arterial
hypertension and coronary artery disease is also accompanied by an increase in the number of correlations and
their nature: in coronary artery disease, there are 6 such links, without it – 4; with arterial hypertension there are
8 correlations, without it there are only 6.
The revealed correlations reflect the relationship between lipids and myocardial remodeling in chronic obstructive
pulmonary disease.
Correlation analysis suggests that the obtained data reflect the interactions of various nodes of the disease
network and can be evaluated as signs of the synthropy of chronic obstructive pulmonary disease, arterial hypertension
and atherosclerosis.
Description
Keywords
коморбидность, хроническое обструктивное заболевание легких, эхокардиография, синтрпоия
Citation
Липиды и структурно-функциональное состояние миокарда при хронической обструктивной болезни лёгких / Т. С. Оспанова, Ж. Д. Семидоцкая, И. А. Чернякова [и др.] // Український журнал медицини, біології та спорту. – 2018. – Т. 3, № 4 (13) – С. 103–109.