Assessment of the vascular wall state in patients with gout and COPD

Abstract

Gouty arthritis worsens the elastic properties of the vascular wall, and the presence of COPD in patients with gout leads to a significant increase in arterial stiffness, the combined course of gout and COPD increases the stiffness of the vessels and reduces their elasticity, which is manifested by an increase in indicators PWV and IА. Essential factors affecting the condition of the vascular wall are smoking experience and the duration of pulmonary and articular pathology. The absence of significant differences in pulse wave velocity in patients with hyperuricemia and healthy individuals, probably indicates that the vascular wall rigidity is less dependent on the level of uric acid, than, for example, on the inflammatory process that occurs at symptomatic gout. In this case, the mechanisms of the possible effect of hyperuricemia on the elastic properties of the vascular wall need further study.