The effect of phosphorus organic mixtures on chromosome aberration and cells’ mitotic activity of red bone marrow in the subacute experiment
Date
2017-12
Authors
Bagmut, Irina
Zharova, Nataliya
Titkova, Anna
Boiagina, Olga
Rezunenko, Yu.
Боягіна, Ольга Дмитрівна
Жарова, Наталія Валентинівна
Тіткова, Анна Володимирівна
Багмут, Ірина Юріївна
Резуненко, Юрій Костянтинович
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
At 100 Wistar rats population in subacute experiment the effect of
small sub-toxic doses of phosphorus detergents (Efasol, Polifos, Syntaf) on the level
of chromosomal aberrations and cells' mitotic activity of red bone marrow was
investigated. There were 9 research groups of animals and one control in certain
clear relationship between dose intensity and toxic effects of restructuring
chromosomal apparatus. The number of cells with chromosomal aberrations in a
dose-dependent (1/10, 1/100 LD50) increased from 5 to 10 times. The study of cells'
mitotic activity of red bone marrow identified reducing mitotic index, which may
indicate the cytostatic effect of phosphorus detergents in appropriate doses 1/10 and
1/100 LD50. All xenobiotics in 1/1000 LD50 dose did not affect the genetic apparatus
of male rats.
Description
Keywords
xenobiotics, phosphorus, detergents, cells' mitotic activiy, red bone marrow, rats
Citation
The effect of phosphorus organic mixtures on chromosome aberration and cells’ mitotic activity of red bone marrow in the subacute experiment / I. Yu. Bagmut, N. V. Zharova, A. V. Titkova, O. D. Boiagina, Yu. K. Rezunenko // The quarterly review of biology. – 2017. – Issue 4 (2), vol. 92. – Р. 701–705.