Please use this identifier to cite or link to this item: http://repo.knmu.edu.ua/handle/123456789/15617
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dc.contributor.authorSyrovaya, Anna-
dc.contributor.authorChalenko, Natalia-
dc.contributor.authorDemchenko, Anatoliy-
dc.date.accessioned2017-02-09T02:35:36Z-
dc.date.available2017-02-09T02:35:36Z-
dc.date.issued2016-
dc.identifier.citationSyrovaya A. O. The Synthesis of Potential Anti-Inflammatory Substances among 4-Amino-5-(Pyridin-4-yl)-1,2,4-Triazole(4н)-3-yl-Thioacetamides and their Chemical Modification / A. O. Syrovaya, N. N. Chalenko, A. M. Demchenko // Der Pharma Chemica. – 2016. – № 8 (21). – P. 17–21.ru_RU
dc.identifier.urihttps://repo.knmu.edu.ua/handle/123456789/15617-
dc.description.abstractSynthesis of new 4-amino-5-(pyridin-4-yl)-1,2,4-triazole(4H)-3-ylthio-acetamides and their pyrrolyl derivatives is described in an article. The initial compound – 4-amino-3-thio-5-(pyridin-4-yl)-1,2,4-triazole(4H) were synthesized by esterification of the initial 4-pyridinecarboxylic acid, and further interaction of resulting methyl ester with hydrazide and potassium 4-pyridine dithiocarbazate wjth the following cyclisation with hydrazine hydrate. The acetamides were obtained by alkylation of the 4-amino-3-thio-5-(pyridin- 4-yl)-1,2,4-triazole(4H) with N-arylsubstituted α-chloracetamides in the presence of KOH. Using Paal-Knorr condensation, the amino group at position 4 was modified into the pyrrole fragment by the action of of 2,5-dimethoxytetrahydrofuran in acetic acid. The preliminary prediction of the possible pharmacological activity by computer prognosis (PASS software) was carried out. Due to the prognosis and analysis of logical data, the substances synthesized will be examined as possible anti-inflammatory agents.ru_RU
dc.language.isoenru_RU
dc.subject4-amino-3-thio-1,2,4-triazoleru_RU
dc.subjectPyridineru_RU
dc.subjectsynthesisru_RU
dc.subjectanti-inflammatory activityru_RU
dc.titleThe Synthesis of Potential Anti-Inflammatory Substances among 4-Amino-5-(Pyridin-4-yl)-1,2,4-Triazole(4н)-3-yl-Thioacetamides and their Chemical Modificationru_RU
dc.typeArticleru_RU
Appears in Collections:Наукові праці. Кафедра медичної та біоорганічної хімії



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