Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/15043
Title: | Experimental therapy of graft-versus-host disease by mesenchymal stromal cells grown on oxide nanocoatings |
Authors: | Goltsev, A. Rassokha, I. Dubrava, T. Ostankova, L. Ostankov, M. Safonov, E. Zykova, A. |
Keywords: | graft-versus-host disease mesenchymal stromal cells nanocoatings |
Issue Date: | 2016 |
Citation: | Experimental therapy of graft-versus-host disease by mesenchymal stromal cells grown on oxide nanocoatings / A. N. Goltsev, I. V. Rassokha, T. G. Dubrava, L. V. Ostankova, M. V. Ostankov, E. A. Safonov, A. V. Zykova // Фiзiологiчний журнал. — 2016. — Т. 62, № 5.— C. 3—11. |
Abstract: | Immune aggression to transplanted allogeneic bone marrow, i.e. the graft-versus-host disease (GVHD), could be decreased by the suppression of effector and/or activation of T- regulatory cells (Тreg). This task could be solved by co-transplantaiton of allogeneic bone marrow and mesenchymal stromal cells (MSCs). This study demonstrated the elevated immune modulating activity of MSCs by their culturing in vitro on Al2O3 oxide nanocoatings. Introduction of the cells to the animals with GVHD resulted in an increased content of Treg in the spleen of bone marrow recipients, reduced severity of the pathology, and higher survival of animals. The findings could be the basis for developing the new approaches to optimize the GVHD treatment methods involving the oxide nanocoating cultured MSCs. |
URI: | https://repo.knmu.edu.ua/handle/123456789/15043 |
Appears in Collections: | Наукові праці. Кафедра медичної біології |
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File | Description | Size | Format | |
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Goltsev_Rassokha_Dubrava_ФЖ_2016_5.pdf | 793,13 kB | Adobe PDF | View/Open |
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