Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/11420
Title: | Показники стану ендотелію у хворих на гіпертонічну хворобу та ожиріння залежно від поліморфізмів генів PPARА та PPARG |
Other Titles: | Indicators of the state of the endothelium in patients with hypertension and obesity based on PPAR gene polymorphisms and PPARG |
Authors: | Babak, Oleg Zhelezniakova, Natalia Molodan, Volodymyr Andrieieva, Anastasiia Prosolenko, Kostyantyn Zelena, Iryna Yarmysh, Natalia Бабак, Олег Якович Железнякова, Наталя Мерабівна Молодан, Володимир Ілліч Андрєєва, Анастасія Олександрівна Просоленко, Костянтин Олександрович Зелена, Ірина Іванівна Ярмиш, Н.В. |
Keywords: | factors of endothelium gene polymorphisms piroksosomalnyh receptors intima-media complex endothelium-dependent vasodilatation hypertension obesity |
Issue Date: | Oct-2015 |
Publisher: | Publishing House WSZiA |
Citation: | Показники стану ендотелію у хворих на гіпертонічну хворобу та ожиріння залежно від поліморфізмів генів PPARА та PPARG / О. Я. Бабак, Н. М.Железнякова, В. І. Молодан, А. О. Андрєєва, К. О. Просоленко, І. І. Зелена, Н. В. Ярмиш // Problems of spatial development of socio-economic systems: economics, education, medicine : monograph. – Opole, 2015. – P. 322–328. |
Abstract: | The aim of the study was assessment of the optimization of the endothelium in hypertensive patients with obesity by identifying the gene polymorphisms piroksosomalnyh receptors (PPAR and PPARG) in combination with inflammation factors. There were examinated 352 patients with hypertension and obesity. Patients matched for age and sex. ELISA was determined the level of CRP, TNF-a, endothelin-1, nitric oxide (eNOs, NOx), IL-4, immunoreactive insulin in the serum. The gene polymorphisms of PPARA and PPARG studying by the polymerase chain reaction. The intima-media complex of common carotid artery measuring by echocardiography on the diagnostic complex «Ultrasound scanner» (USA). The obtained results indicate that patients - carriers 162Val allele gene PPAR observed more reduction endothelium-dependent vasodilation and simultaneous increase of endothelin-1 and metabolite concentration NOx, which is evidence of more severe violations of the functional state of the endothelium. If detected genotype Pro12Pro determined by the thickness of intima-media of common carotid artery, it would indicate an earlier development of atherosclerotic process. There is a significant difference between the metabolite concentrations of NOx and systemic inflammation in patients with genotypes Leu/Leu gene PPAR. |
URI: | https://repo.knmu.edu.ua/handle/123456789/11420 |
ISBN: | 978-83-62683-64-0 |
Appears in Collections: | Наукові праці. Кафедра внутрішньої медицини № 1 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
БабакОЯХарківРозділ5.doc | 106 kB | Microsoft Word | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.