Please use this identifier to cite or link to this item: http://repo.knmu.edu.ua/handle/123456789/10309
Title: Protease-antiprotease imbalance in the progression of chronic heart failure in patients with chronic obstructive pulmonary disease combined with arterial hypertension
Authors: Дєлєвська, Валентина Юріївна
Keywords: arterial hypertension
chronic obstructive pulmonary disease
chronic heart failure
matrix metalloprotease 9
α2-macroglobulin
Issue Date: 23-Sep-2015
Citation: Dielievska V. Yu. Protease-antiprotease imbalance in the progression of chronic heart failure in patients with chronic obstructive pulmonary disease combined with arterial hypertension / V. Yu. Dielievska // Український кардіологічний журнал. Додаток 1 : Матеріали XVI Національного конгресу кардіологів України, 23-25 вересня 2015 р. - 2015. - С. 56.
Abstract: The aim – to investigate the changes of protease-antiprotease system in patients with chronic obstructive pulmonary disease (COPD) in combination with arterial hypertension (AH) while progression of chronic heart failure (HF). Conclusions. The progression of HF in patients with AH and COPD is accompanied by the decrease of the proteolysis inhibitor α2-macroglobulin along with high activity of connective tissue degradation processes as observed by increased matrix metalloprotease 9. The observed protease-antiprotease imbalance in patients with AH and COPD causes the changes in extracellular matrix proteins metabolism, resulting in myocardial remodeling, that underlies the pathogenesis of HF.
URI: http://repo.knmu.edu.ua/handle/123456789/10309
Appears in Collections:Наукові роботи молодих вчених. Кафедра внутрішньої медицини № 2 і клінічної імунології та алергології ім. ак. Л.Т. Малої

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