Bagmut, IrinaZharova, NataliyaTitkova, AnnaBoiagina, OlgaRezunenko, Yu.Боягіна, Ольга ДмитрівнаЖарова, Наталія ВалентинівнаТіткова, Анна ВолодимирівнаБагмут, Ірина ЮріївнаРезуненко, Юрій Костянтинович2017-11-142017-11-142017-12The effect of phosphorus organic mixtures on chromosome aberration and cells’ mitotic activity of red bone marrow in the subacute experiment / I. Yu. Bagmut, N. V. Zharova, A. V. Titkova, O. D. Boiagina, Yu. K. Rezunenko // The quarterly review of biology. – 2017. – Issue 4 (2), vol. 92. – Р. 701–705.0033-5770https://repo.knmu.edu.ua/handle/123456789/18157At 100 Wistar rats population in subacute experiment the effect of small sub-toxic doses of phosphorus detergents (Efasol, Polifos, Syntaf) on the level of chromosomal aberrations and cells' mitotic activity of red bone marrow was investigated. There were 9 research groups of animals and one control in certain clear relationship between dose intensity and toxic effects of restructuring chromosomal apparatus. The number of cells with chromosomal aberrations in a dose-dependent (1/10, 1/100 LD50) increased from 5 to 10 times. The study of cells' mitotic activity of red bone marrow identified reducing mitotic index, which may indicate the cytostatic effect of phosphorus detergents in appropriate doses 1/10 and 1/100 LD50. All xenobiotics in 1/1000 LD50 dose did not affect the genetic apparatus of male rats.enxenobioticsphosphorusdetergentscells' mitotic activiyred bone marrowratsArticle