Kovalyova, OlgaКовальова, Ольга МиколаїівнаZhuravlyova, AnnaЖуравльова, Анна КостянтинівнаIvanchenko, SvitlanaІванченко, Світлана Володимирівна2023-10-072023-10-072023Kovalyova O. Renin-angiotensin system: a review of historical perspectives / O. Kovalyova, A. Zhuravlyova, S. Ivanchenko // Galician Medical Journal. – 2023. – № 30 (2). – P. 1–10.https://repo.knmu.edu.ua/handle/123456789/32578The article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the subsequent discoveries of angiotensin-converting enzyme 2, angiotensin-(1-7), Mas receptor. This paper presents a modern classification of the renin-angiotensin system, dividing it into classical and non-classical branches, based on the determination of the biological effects of its components. Significant attention is devoted to elucidating the biochemical cascade of the renin-angiotensin system, its physiological transformations, and its implications in human body processes. The detrimental cardiac effects of the classical renin-angiotensin system are highlighted, along with the crucial role played by its alternative axis in counteracting the development of cardiovascular diseases. The article presents data on the involvement of angiotensin-converting enzyme 2 and its receptors in coronavirus infections, susceptibility to infection, and disease progression.enrenin-angiotensin systemangiotensin-converting enzymeangiotensinmas receptor2023аArticle