VOLUME LXXVI, ISSUE 8, AUGUST 2023 ISSN 0043-5147 E-ISSN 2719-342X INDEXED IN PUBMED/MEDLINE, SCOPUS, EMBASE, EBSCO, INDEX COPERNICUS, POLISH MINISTRY OF EDUCATION AND SCIENCE, POLISH MEDICAL BIBLIOGRAPHY Official journal of Polish Medical Association has been published since 1928 ALUNA Publishing VOLUME LXXVI, ISSUE 8, AUGUST 2023 ISSN 0043-5147 E-ISSN 2719-342XOfficial journal of Polish Medical Association has been published since 1928 Wiadomości Lekarskie is abstracted and indexed in: PUBMED/MEDLINE, SCOPUS, EMBASE, INDEX COPERNICUS, POLISH MINISTRY OF EDUCATION AND SCIENCE, POLISH MEDICAL BIBLIOGRAPHY Copyright: © ALUNA Publishing. 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Przesmyckiego 29, 05-510 Konstancin – Jeziorna www.wydawnictwo-aluna.pl www.wiadomoscilekarskie.pl www.wiadlek.pl Editor in-Chief: Prof. Władysław Pierzchała Deputy Editor in-Chief: Prof. Aleksander Sieroń Statistical Editor: Dr Lesia Rudenko Managing Editor: Agnieszka Rosa – amarosa@wp.pl International Editorial Office: Nina Radchenko (editor) – n.radchenko@wydawnictwo-aluna.pl Polish Medical Association (Polskie Towarzystwo Lekarskie): Prof. Waldemar Kostewicz – President PTL Prof. Jerzy Woy-Wojciechowski – Honorary President PTL 1706 Wiadomości Lekarskie Medical Advances, VOLUME LXXVI, ISSUE 8, AUGUST 2023 © Aluna Publishing CONTENTS ORIGINAL ARTICLES Olha Prykhodko, Olga Avilova, Serhii Dmytruk, Alina Ponyrko, Olena Gordienko, Eleonora Prykhodko HISTOULTRASTRUCTURAL FEATURES OF THYMOCYTES DUE TO THE IMPACT OF THE EXPERIMENTAL GENERAL DEHYDRATION OF A MILD DEGREE 1709 Yuliya Mozgova, Maryna Mishyna, Vasyl Syplyviy, Oleksandr Ievtushenko, Dmytro Ievtushenko, Iryna Marchenko, Yuriy Mishyn MICROBIOLOGICAL ANALYSIS OF ABDOMINAL CAVITY EXUDATE, BLOOD AND AFFECTED TISSUES SAMPLES FROM PATIENTS WITH INTRA-ABDOMINAL ABSCESSES IN COMPLICATED INFECTION OF ABDOMINAL CAVITY 1717 Anastasiia Ye. Alatorskykh, Pavlo V. Fedorych, Serhii B. Koval, Taras V. Kuts TREATMENT OF COMBINED ACNE AND GENITOURINARY INFECTIONS CAUSED BY CHLAMYDIA AND MYCOPLASMAS 1725 Yulian Bursuk, Andrii Babko, Serhii Savosko, Ruslan Serhiienko, Olifirenko Oleksii, Viktor Lykhodii, Anna Kondaurova CHANGES IN ARTICULAR CARTILAGE OF THE HIP JOINT INDUCED BY ACETABULAR LABRUM DAMAGE 1730 Svitlana Myronchenko, Tetyana Zvyagintseva, Nina Gridina, Nataliia Kytsiuk, Yehor Zhelnin THE ROLE OF NITRIC OXIDE AND PEROXYNITRITE IN THE ERYTHEMAL PERIOD OF ULTRAVIOLET-INDUCED SKIN DAMAGE 1737 Hanna Lytvynenko, Olga Lytvynova, Vadym Lytvynov, Mycola Lytynenko, Sergey Latoguz CHANGES IN THE SERUM LEVEL OF LEPTIN AND TRANSFORMING GROWTH FACTOR-Β1 IN PATIENTS WITH ARTERIAL HYPERTENSION ON A BACKGROUND OF ABDOMINAL OBESITY 1742 Ihor Deneha, Olha Ripetska, Oleg Mokryk, Volodymyr Hrynovets, Svitlana Ushtan, Yuliia Tykhovska-Izhytska RELATIONSHIP BETWEEN THE DYSTROPHIC MANIFESTATIONS IN THE PERIODONTIUM AND INTESTINAL DYSBACTERIOSIS 1748 Kateryna Pikul, Valentina Ilchenko, Liudmyla Syzova, Oksana Muravlova, Iryna Dvornyk INFECTIOUS MONONUCLEOSIS DURING THE WAR AND COVID INFECTION PANDEMIC IN UKRAINE 1754 Oleksandra Yu. Kushnir, Iryna M. Yaremii, Kyrylo A. Pantsiuk, Volodymyr V. Vivsyannuk, Diana M. Tymkul, Kateryna V. Vlasova, Olena V. Vlasova CARBOHYDRATES METABOLISM IN THE BLOOD OF RATS WITH IMPAIRED GLUCOSE TOLERANCE UNDER LONG TERM MELATONIN INJECTIONS 1761 Yuriy Sobolevskiy, Oleksandr A. Burianov, Volodymyr Kvasha, Yevheeniy Skobenko, Taras Omelchenko, Vasyl Parii BIOMECHANICAL STUDY OF MINIMALLY INVASIVE TECHNIQUES IN SURGICAL TREATMENT OF THE TIBIA PROXIMAL EPIMETAPHYSIS FRACTURES 1768 Grygoriy P. Griban, Natalia A. Lyakhova, Dmytro G. Oleniev, Oksana P. Kanishcheva, Liana V. Duhina, Tetiana S. Ostrianko, Ostap S. Skoruy DYNAMICS OF TOBACCO SMOKING PREVALENCE AMONG STUDENTS AND DIRECTIONS OF ITS PREVENTION 1776 © Aluna Publishing 1707 Wiadomości Lekarskie Medical Advances, VOLUME LXXVI, ISSUE 8, AUGUST 2023© Aluna Publishing Vasyl I. Rusyn, Fedir M. Pavuk, Vasyl Yа. Fedusyak INFLUENCE OF THE AMOUNT OF COMPRESSION ON VENOUS AND ARTERIAL BLOOD FLOW VELOCITY AND SKIN MICROCIRCULATION OF THE LOWER EXTREMITY 1783 Vasyli B. Makarov, Ninel V. Dedukh, Olga A. Nikolchenko FEATURES OF BONE REMODELING AROUND SURFACE-MODIFIED TITANIUM AND TANTALUM IMPLANTS 1790 Olena V. Kravchenko, Olena A. Tiulienieva, Svitlana M. Yasnikovska, Alisa V. Goshovska FEATURES OF THE FUNCTIONAL MORPHOLOGY OF THE FULL-TERM PLACENTA IN WOMEN WITH THREATENED ABORTION WITH BLEEDING IN THE FIRST TRIMESTER OF GESTATION 1797 Vasyl Suvorov, Viktor Filipchuk, Michailo Melnyk THE BIOMECHANICAL ANALYSIS OF PELVIC OSTEOTOMIES APPLIED FOR DDH TREATMENT IN PEDIATRIC PATIENTS 1804 Tetiana Vasheka, Oksana Vlasova-Chmeryk, Borys Palamar, Olena Dolgova, Oleksandr Pravda, Sergii Tukaiev, Svitlana Palamar COPING STRATEGIES AND PSYCHOLOGICAL ADJUSTMENT TO THE COVID-19 PANDEMIC AMONG THE UKRAINIAN STUDENTS’ YOUTH 1813 REVIEW ARTICLES Viktoriia V. Nadon , Marija V. Mendzhul, Alina V. Hus APPLICATION OF SURROGACY TECHNOLOGY BY FOREIGNERS IN UKRAINE (LEGAL CONFLICT) 1819 Liudmyla A. Vygivska, Natalia V. Derevianchenko, Lesia A. Rudenko, Oleh R. Chebotenko PREECLAMPSIA AND ITS EFFECT ON THE STATE OF CARDIOVASCULAR SYSTEM IN WOMEN 1826 Oleh E. Kanikovskyi, Ihor V. Pavlyk, Yuliia A. Punko, Oleksandr L. Machovskyi, Iryna V. Oliinyk TREATMENT OF PATIENTS WITH CHRONIC PANCREATITIS COMPLICATED BY PANCREATORAGIA 1831 Halyna V. Bilavych, Nataliia М. Blahun, Oktaviia J. Fizeshi, Svitlana J. Dovbenko, Olena M. Shapoval, Nadiya O. Fedchyshyn, Borys P. Savchuk CURRENT PROBLEMS IN COMMUNICATIVE DEVELOPMENT OF CHILDREN WITH SPECIAL EDUCATIONAL NEEDS: UKRAINIAN AND EUROPEAN SCIENTIFIC CONTEXTS 1838 Anatolii V. Vykhrushch, Nadiia A. Danik, Nadiya O. Fedchyshyn, Larysa Ya. Fedoniuk, Tetiana I. Khvalyboha, Solomiia I. Hnatyshyn, Olha M. Khrystenko DIDACTIC CULTURE OF MEDICAL UNIVERSITY TEACHERS AND STUDENTS IN THE CONDITIONS OF WAR 1846 © Aluna Publishing 1708 Wiadomości Lekarskie Medical Advances, VOLUME LXXVI, ISSUE 8, AUGUST 2023 © Aluna Publishing © Aluna Publishing CASE STUDIES Mykhailo D. Protsailo, Olga Ye. Fedortsiv, Volodymyr G. Dzhyvak, Ihor O. Krycky, Pavlo V. Hoshchynskyi, Ihor M. Horishnyi, Iryna B. Chornomydz, Yana V. Rohalska, Vira O. Synytska, Andrii M. Prodan, Iryna M. Nikitina CLINICAL FEATURES OF CONNECTIVE TISSUE DYSPLASIA, OSGOOD-SCHLATTER DISEASE AND MULTIPLE CORTICAL DISORDERS IN A CHILD 1854 Yulia A. Tkachenko, Yuriy V. Shkatula, Svitlana N. Kasyan, Yuriy O. Badion MANAGEMENT OF COMPLICATIONS FOLLOWING BUTTON BATTERY INGESTION 1861 VARIA Tetiana Danylova, Anatoliy Vovk, Ihor Hoian, Svitlana Kholodynska, Kateryna Honcharenko, Olena Ishchenko, Anna Bezhnar PHILOSOPHY AND MENTAL HEALTH 1866 Svіtlana Storozhuk, Andrii Petraniuk, Nataliia Kryvda, Dmytro Tovmash, Iryna Matviienko, Yevhenii Shushkevych, Ali Hamaidia TOWARD A HEALTHY SOCIETY: WHEN TRAUMA AFFECTS GROUP IDENTITY 1874 1826 © Aluna PublishingWiadomości Lekarskie Medical Advances, VOLUME LXXVI, ISSUE 8, AUGUST 2023 INTRODUCTION Cardiovascular diseases rank first among all causes of disability and mortality of the population. Arterial hy- pertension (AH), as the most common representative of this cohort of diseases, occupies a special place among the most pressing issues of medicine in general and the medico-social well-being of mankind. To date, an increase in the mortality rate from cardiovascular diseases (CVDs) has been noted in women, both individually and in com- parison with men. Cases of cardiovascular impairments have become more frequent among women of young age (from 25 to 35 years), but the causes of their devel- opment are at the stage of consideration [1]. An opinion is expressed about the connection of CVDs in women with pregnancy and its pathological conditions [2]. Since pregnancy is a special stage of a woman’s life and is a “stress test” for all body systems, its complications can become powerful inducers of the development of various somatic diseases, even in healthy young women [3]. THE AIM To determine the features of the impact of preeclamp- sia on the development of cardiovascular disorders in women in the future. MATERIALS AND METHODS The study involved an assessment of literary sources, which were published mainly in the last five years, using scientometric and specialized databases Pubmed, Sci- ence direct, Scopus, Web of Science, Google Scholar and V.I. Vernadskyi NLU “Scientific Periodicals of Ukraine”. REVIEW AND DISCUSSION Preeclampsia (PE) is a complication of pregnancy, which is considered a multisystem abnormal process with characteristic manifestations in the form of arterial hypertension (an increase in arterial systolic pressure ≥ 140 mmHg and diastolic pressure ≥ 90 mmHg) and proteinuria (significant ≥ 0.3 g per day), developing after the 20th week of pregnancy. PE has a complex pathophysiological mechanism, and is currently not fully understood. Currently, the main links of the pathogenesis of this abnormality are considered to be as follows: endothelial dysfunction, changes in the reactivity of the immune system, metabolic transfor- mations with the formation of oxidative stress, features of lipid metabolism, changes in the concentration of cytokine components, activation of the primary links of inflammation, etc. [4-7]. PREECLAMPSIA AND ITS EFFECT ON THE STATE OF CARDIOVASCULAR SYSTEM IN WOMEN DOI: 10.36740/WLek202308118 Liudmyla A. Vygivska1, Natalia V. Derevianchenko1, Lesia A. Rudenko2, Oleh R. Chebotenko1 1KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE 2ALUNA PUBLISHING HOUSE, KONSTANCIN-JEZIORNA, POLAND ABSTRACT The aim: To determine the features of the impact of preeclampsia on the development of cardiovascular disorders in women in the future. Materials and methods: The study involved an assessment of literary sources, which were published mainly in the last five years, using scientometric and specialized databases Pubmed, Science direct, Scopus, Web of Science, Google Scholar and V.I. Vernadskyi NLU “Scientific Periodicals of Ukraine”. Conclusions: Cardiovascular disorders are not only a medical problem, but also a social one. Preeclampsia is a dangerous condition that contributes to the development of CVDs, increases the rate of mortality and disability among women. All this makes it absolutely necessary to study the features of the pathogenesis in detail, to understand exactly how, through which mechanisms, the preeclamptic state affects the woman’s body, and this will allow doctors to indirectly influence its pathogenesis and reduce negative consequences and improve the quality of life. KEY WORDS: preeclampsia, cardiovascular diseases, risk of development, pathogenic links, cardiovascular biomarkers Wiad Lek. 2023;76(8):1826-1830 REVIEW ARTICLE PREECLAMPSIA AND ITS EFFECT ON THE STATE OF CARDIOVASCULAR SYSTEM IN WOMEN 1827 Why is preeclampsia of interest not only to obstetri- cians and gynecologists, but also to related specialists? Because it is characterized by the development of very serious complications, such as eclampsia (E), acute renal failure (ARF), HELLP syndrome, malignant arterial hyper- tension. But doctors do not always pay timely attention to the first manifestations of this grave disorder, which can rightfully be considered an inducer of the develop- ment of cardiovascular diseases [8]. The opinions of advanced obstetric schools, foreign and domestic scientists, and the European Society of Cardiology agree that the course of preeclampsia provokes the development of cardiovascular diseases, and subsequently chronic diseases of other organs and systems. [9-11]. In this regard, the American Heart Association in- cluded PE among the risk factors for the development of cardiovascular diseases (CVDs) in women [12-14]. CVD development is underlain by common patho- genic links of PE advancement, therefore, it is necessary to specify their definition, which will make it possible to prevent their occurrence and reduce the risk of CVD in a specific woman and in the population as a whole [15]. It is well known that pregnancy is stressful for the mother’s body, and the development of obstetric complications in the future can increase the risk of de- veloping CVDs. Research in recent years confirms the presence of long-term cardiovascular complications in women who had preeclampsia during pregnancy. Thus, women with a history of preeclampsia have an increased risk of such future CVDs as chronic hyper- tension, heart failure, stroke, coronary heart disease, and cardiovascular mortality [16-17]. Yes, according to A. I. Lokki et al. [18], women with preeclampsia without CVD risk factors 90 days postpartum had twice the risk of CVDs as manifested by coronary artery revascular- ization, cerebrovascular disease, or peripheral artery disease. At the same time, in women with a history of preeclampsia and metabolic syndrome, this risk in- creased almost 12 times. According to the results of a study by British scientists, in women with preeclampsia, the overall frequency of the first cardiovascular events within nine years after childbirth was 2.77% compared to women after an uncomplicated pregnancy (1.4%) [19]. Another evidence of such a relationship is that, according to current recommendations, pregnancy history is part of the routine assessment of CVD risk in women [20]. Therefore, maladaptation of the cardiovas- cular system during pregnancy increases the tendency to develop CVDs in the postpartum period. Currently, several pathways are known regarding the etiological relationship between preeclampsia and CVDs. On the one hand, it has been suggested that pre- eclampsia can be a predictor of cardiovascular events through various pathways [21]. On the other hand, the relationship between future CVDs and preeclampsia is partially explained by the common risk factors: dyslip- idemia, insulin resistance, diabetes, obesity, endothelial dysfunction, increased inflammatory reactions, hyper- coagulation states [22]. According to modern concepts, preeclampsia results from hypoperfusion and hypoxia of the placenta, occur- ring due to the improper development of the uterine placental spiral arteries. These conditions trigger an inflammatory reaction, which can cause endothelial dysfunction and vasoconstriction, mediating the risk of future CVDs [23-24]. According to G. Kalapotharakos et al. [25], it is vascular mechanisms, as opposed to cardiac hypertrophy, that may cause increased long-term cardiovascular risk after preeclampsia. A. R. Markovitz et al. [26] showed the etio- logical relationship between the development of preg- nancy complications and disorders of the functioning of the cardiovascular system, manifested by metabolic syndrome, vascular dysfunction or inflammation. Preeclampsia is characterized by an abnormal rear- rangement of placental vessels, causing uteroplacental ischemia. Under such conditions, spiral arteries do not undergo physiological transformation, maintaining thick walls with a narrow lumen. Such remodeling of spiral arteries accelerates maternal blood flow in the intervillous space. Maternal blood flow, which speed is approximately 1–2 m/s, is characterized by a strong impulse, resulting in destruction of villi and formation of an echogenic cystic lesion lined with blood clots, which can enter the mother’s body [27]. At the same time, the failure of remodeling leads to a repeated cycle of placental ischemia/reperfusion and causes endothe- lial dysfunction, changes vascular tone, increases the formation of reactive oxygen species (ROS), the release of inflammatory cytokines, antiangiogenic factors, as well as an imbalance of maternal immune cells [28]. ROS reduce the bioavailability of nitric oxide, which is a proangiogenic factor, as a result of which vasodilation and angiogenesis are disturbed, and the bioavailability of antiangiogenic factors — soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng) — increas- es [29]. sFlt-1 through binding of vascular endothelial growth factor and placental growth factor is asso- ciated with defective angiogenesis and endothelial dysfunction, sEng initiates proliferation and migration of endothelial cells. Researchers believe that these antiangiogenic biomarkers significantly contribute to endothelial damage during pregnancy in the case of preeclampsia, but do not remain elevated after deliv- ery [27]. A. E. Stanhewicz [30] suggests that vascular Liudmyla A. Vygivska et al. 1828 damage during preeclampsia persists and contributes to the cascade of CVD development. Endothelial dysfunction is associated with inflamma- tion, the consequence of which is atherosclerosis. Lipids are deposited in the walls of the spiral arteries of the uterus, which is similar to the early stages of athero- sclerosis [31]. According to S. C. A. de Jager et al. [28], in women with preeclampsia, the endothelium does not completely recover, remaining more sensitive to inflammation, as is observed in the case of atheroscle- rosis. C. Anthoulakis and A. Mamopoulos [32] found that the pulse wave speed and the augmentation index at a heart rate of 75 beats per minute are higher in pregnan- cies complicated by preeclampsia. The authors believe that assessment of arterial stiffness is a promising tool for risk stratification of cardiovascular complications in the future. Thus, three important stages of the pathophysiology of preeclampsia have been identified: placental hypoxia and oxidative stress, excessive release of antiangiogenic and proinflammatory factors, and widespread systemic endothelial dysfunction and vasoconstriction [33-34]. There is evidence to suggest that suboptimal tropho- blastic invasion causes an imbalance of angiogenic and antiangiogenic proteins, ultimately causing widespread inflammation and endothelial damage, increased plate- let aggregation, and thrombotic events with placental infarctions [35]. S. Sławek-Szmyt et al. [36], having conducted a review of studies on the relationship between preeclampsia and the long-term risk of CVDs in mothers, concluded that there are common pathophysiological pathways between them. At the same time, scientists drew atten- tion to insufficient study of intermediate mechanisms (chronic bacterial infections, TNFα) responsible for this association. Pregnancy often occurs at an early stage of a woman’s life, when usually CVDs have not yet been detected. Therefore, the issue of screening and prevention of CVDs in women with preeclampsia arises. In this case, determining the level of cardiovascular biomarkers may be useful for predicting the risk of developing CVDs. Biomarkers such as sFlt-1, placental growth factor, in- terleukin (IL)-6, IL-6/IL-10 ratio, high-sensitivity cardiac troponin I, activin A, soluble human leukocyte antigen G, pregnancy-associated plasma protein A, and norepi- nephrine can be potentially suitable for cardiovascular risk stratification after preeclampsia and contribute to the development of prevention strategies [37]. Although a history of preeclampsia is recognized as a specific risk factor for CVDs later in life, it is still unclear how to improve the cardiovascular health of these women. Currently, some guidelines suggest monitoring for hypertension, hyperlipidemia, and diabetes, as well as providing advice on a healthy lifestyle for women with a history of preeclampsia [38]. Further research is needed to determine appropriate monitoring strategies for such women. CONCLUSIONS Cardiovascular disorders are not only a medical prob- lem, but also a social one. 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Chebotenko: 0000-0002-5789-6341 D,F Conflict of interest: The Authors declare no conflict of interest. CORRESPONDING AUTHOR Liudmyla A. Vygivska Kharkiv National Medical University 4 Nauky Avenue, 61000 Kharkiv, Ukraine e-mail: liudmilavygovskaya@gmail.com Received: 03.03.2023 Accepted: 25.07.2023 A - Work concept and design, B – Data collection and analysis, C – Responsibility for statistical analysis, D – Writing the article, E – Critical review, F – Final approval of the article Article published on-line and available in open access are published under Creative Com mon Attribution-Non Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0)