kV-*»' ESPGHAN/ / 56th Annual Meeting of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition 15-18 May 2024 | Milan, Ita ly www.espghancongress.org Abstracts E-Book http://www.espghancongress.org 'ESPGHAN 15-18 May 2024 | M ilan, Ita ly 56th Annual Meeting of the European Society For Paediatric Gastroenterology, Hepatology and Nutrition Table of Contents ORAL PRESENTATIONS...............................02 POSTER WALK ON BOARDS.......................285 E-POSTER PRESENTATIONS...................... 419 POSTERS ON BOARDS................................ 559 E-POSTER VIEWING..................................... 1208 ENDOSCOPY VIDEO E-POSTERS............... 1684 AUTHOR INDEX............................................1699 FESPGHAN H-071 15-18 May 2024 | M ilan, Ita ly 56th Annual Meeting of the European Society For Paediatric Gastroenterology, Hepatology and Nutrition Topic: AS02. HEPATOLOGY/ AS02a. General Hepatology Posters Onsite on Boards POSTER VIEWING ON BOARDS: HEPATOLOGY - AS02A. GENERAL HEPATOLOGY 15-05-2024 08:00 - 19:00 BIOCHEMICAL INDICATORS OF LIVER FIBROGENESISIN CHILDREN WITH OBESITY Larysa Strashok1, Olena Buznytska2, Elina Zavelya1, Margaryta Khomenko3 1Pediatrics, Kharkiv National Medical University, 1SI «Institute for Children and Adolescents Health Care of the NAMS of Ukraine», Ukraine, Kharkiv, Ukraine, 2Pediatrics, V.N. Karazin Kharkiv National University, 1SI «Institute for Children and Adolescents Health Care of the NAMS of Ukraine», Ukraine, Kharkiv, Ukraine, 3Pediatrics, V.N. Karazin Kharkiv National University, Kharkiv, Ukraine Objectives and Study: To improve the effectiveness of noninvasive diagnosis of liver fibrosis in children with obesity using serum biomarkers of liver fibrogenesis. Methods: On the base of SI “Institute for Children and Adolescents Health Care of the NAMS of Ukraine”, Kharkiv, were inspected 226 patients with obesity in age 8-18 years and 30 healthy children for control group. Investigation of liver fibrogenesis consisted of measurement in blood serum of level Fibronectin (70±14.0 mkg/ml), serum collagen type IV (99±2.3 mkg/l). Statistical processing was made by program Statistics. Results: It was found that 113 (50.0 ± 3.33%) patients had insulin resistance (IR) according the level of the HOMA-IR index. The study of liver fibrogenesis revealed a significant increase in levels of type IV collagen and fibronectin in children with obesity (p< 0.05), (Table 1).The levels of Fibronectin significantly differed in groups, depending on the presence of IR, which apparently indicates a more severe liver damage in children with IR (p < 0.05). Table 1.Levels of collagen type IV and fibronectin (M ± a) Children with obesity n Collagen type IV, mkg/l Fibronectin, mkg/ml IR + 113 107.61 ± 7.04* 115.86 ± 7.20* ** IR - 113 103.76 ± 8.31* 93.00 ± 6.31* Controlgroup 30 85.91 ± 2.38 78.36 ± 2.12 * Difference between patients with obesity and healthy children (p < 0.05) ** Difference between patients with IR and without it (p < 0.05) Conclusions: Thus, non-invasive diagnostic methods using serum biomarkers (type IV collagen, Fibronectin) have confirmed their diagnostic significance in establishing of liver fibrogenesis on the early stages formation in children with obesity. Contact e-mail address: laspediatr1984@gmail.com mailto:laspediatr1984@gmail.com 56th Annual M eeting o f the European ‘ r==> "» I I A K 1 Society for Paediatric Gastroenterology, j | | | | ^ Hepatology and N utrition ^ 15-18 Mav 2024 1 Milan. Ita lv S to lo v a s ,A ie le t - G -O 015 S to ltz S jo s tro m ,E lisa b e th - N -O 0 1 5 S to p k a ,W ik to r - H -O 0 2 7 S to rd a l,K e til - G -2 8 0 , G -O 0 0 5 , G -O 0 0 8 , G -O 0 6 7 , G -O 0 7 7 , G -O 0 9 0 St0rd a l,K e til - E P P 0 4 5 , N -1 3 0 S to rm o n ,M ich ae l - E P P 0 2 5 , H -O 0 1 0 S t P e te r ,S h a w n D . - G -3 1 6 S tra c u z z i,M a rta - H -O 0 2 5 S tra in ,Ja m ie - H -O 0 2 3 S tran ak ,Z b y n ek - E P V 3 2 2 S tra sh o k ,L a ry sa - H -0 7 1 , H -0 7 2 , H -073 S tra tto n ,M ich a e l R . - G -3 1 7 S tra tto n ,R e b e c c a J - E P P 0 1 0 , N -0 4 0 , N -041 S trick e r,S eb as tian - E P V 0 6 4 , G -0 0 1 , G -O 0 1 2 , I-005 S tr isc iu g lio ,C a te rin a - E P P 0 5 3 , E P P 0 6 4 , E P P 0 6 8 , G -0 8 2 , G -0 8 3 , G -0 9 5 , G -1 6 7 , G -1 8 5 , G -1 9 2 , G -2 0 2 , N -0 7 0 S tro p p a ,P a o la - H -101 S tru y s ,E d u a rd A . - E P P 055 S tu d y G ro u p ,C e d a ta - G -2 1 3 , G -O 055 S tu d y G ro u p ,Im p e n sa - I-O 005 S tü k e r,D ie tm a r - H -0 0 7 S tu rm ,E k k eh a rd - H -0 0 7 , H -0 4 8 , H -0 6 4 , H -O 0 0 9 , H -O 0 2 2 , H -O 0 2 6 , H -O 0 3 1 , H -O 0 3 7 , N -O 0 2 8 S tu tts ,Jo h n T . - E P V 291 S u a re z ,M a rg a r ita - E P V 2 5 1 , E P V 2 5 2 S u arez T ra b a ,O lg a M a r ia - E P V 172 S u c h ism ita ,A ry a - H -O 0 0 3 , H -O 0 1 8 S u d arm o ,S u b ijan to M . - G -163 S u k arja ,D is ty ay u - N -0 8 9 , N -0 9 0 S u m e r C o sa r,O z lem - E P V 1 0 7 , E P V 1 3 7 , E P V 1 5 8 , H -0 7 4 S u m itro ,K h ad ijah R. - G -163 S u n d a ra m ,S h ik h a S. - E P P 0 2 5 , H -O 0 1 0 S u n ,G u iju - E P V 3 3 0 S u n ,L in a - E P P 0 7 4 , E P V 166, G - 124, G -241 S u n ,T ian - H -0 4 9 S u p erin a ,R ic ca rd o - H -O 0 1 9 , H -O 0 4 0 S u p h a p e e tip o rn ,K a n y a - H -0 6 8 S u p p a p itip o rn ,S ir ilu c k - E P V 2 9 0 S u ra ta n n o n ,N a rissa ra - G -3 0 2 S u ri,V an i - G -0 9 9 S ü rm eli O n a y ,O z g e - N -O 0 1 4 56th Annual M eeting o f the European ‘ r==> "» I I A K 1 Society for Paediatric Gastroenterology, j | | | | ^ Hepatology and N utrition ^ 15-18 Mav 2024 1 Milan. Ita lv Z ara te M o n d ra g 6 n ,F lo ra E. - E P V 225 Z a ru b o v a ,K ris ty n a - G -2 1 4 , N -0 7 2 Z a v e ly a ,E lin a - H -0 7 1 , H -0 7 2 Z a v h o ro d n ia ,N a ta lia - H -0 8 7 , H -0 8 8 Z a w o rsk i,K a m il - G -O 0 1 7 Z d a n o w ic z ,K a ta rz y n a - E P V 0 9 1 , E P V 1 5 6 , E P V 1 9 2 Z d u n -R y z e w sk a ,A g a ta - G -128 Z e c c o lin i,M a ss im o - G -1 3 4 Z e e v e n h o o v e n ,Ju d ith - G -1 5 6 Z e llo s ,A g la ia - E P P 0 2 5 , E P P 0 6 8 , E P V 2 7 5 , G -O 0 8 7 , H -O 0 1 0 Z e m h e ri,I t ir E b ru - E P V 197, E P V 198 Z en g ,Z h e A . - N -1 3 8 , N -1 5 4 Z e n i,N ic o la - E P V 2 6 8 Z e n k o v a ,K a rin a - E P V 3 0 7 Z e p c iu c ,A d e lin a - G -038 Z e re m ,M a ta n - G -O 0 3 7 Z e r lo tin ,P a o la - E P P 0 7 6 Z e tte rs tro m ,C e c ilia K . - G -2 5 6 Z e tte r s tro m ,R o lf - G -008 Z e v it,N o a m - E P P 0 6 4 , G -0 2 9 , G -0 6 4 , G -0 8 5 , G -O 0 2 5 Z h a n g ,B in - N -0 8 2 , N -1 5 5 Z h a n g ,F a n - G -O 0 6 2 , N -1 5 6 Z h a n g ,J in p in g - E P V 3 2 6 , N -0 2 6 , N -0 6 1 , N -O 0 3 3 Z h a n g ,L e - E P V 0 6 0 Z h a n g ,M a o lin - N -O 0 2 7 Z h a n g ,T in g - E P P 0 7 3 , G -1 5 7 , G -2 1 1 , G -2 1 2 , N -0 2 3 , N -0 2 5 , N -1 1 2 Z h a n g ,X in - E P P 0 5 9 , G -O 0 7 0 , G -O 0 7 9 Z h a n g ,Y a n - N -1 4 5 , N -1 5 7 , N -O 0 3 2 Z h ao ,H o n g m e i - E P P 0 1 4 Z h ao ,X ia n fe n g - N -0 7 5 , N -081 Z h a o ,Y u lin g - G -O 0 2 4 , N -O 0 2 9 Z h e ly a z k o v a ,D e s is lv a - N -1 1 6 Z h e n g ,H e n g q i B e tty - G -0 9 2 Z h e n g ,Y u h u a - G -O 0 1 6 Z h en g ,Y u x in g - N -0 8 2 Z h o n g ,W a n y in g - N -1 3 8 , N -1 5 4 Z h o u ,J ie - G -O 023 Z h o u ,J in - E P V 3 3 0 Z h o u ,Y o n g c h a n g - H -O 011 Z h u a n g ,W e ih o n g - N -1 0 5