Morphological efficacy evaluation of gel with carbon dioxide extract of hops in case of complicated wound infection acne vulgaris

dc.contributor.authorMoiseienko, Tetiana
dc.contributor.authorTorianyk, Inna
dc.contributor.authorKhrystian, Gennadiy
dc.contributor.authorRybak, Viktoria
dc.contributor.authorVoronkina, Iryna
dc.contributor.authorMelnyk, Anatoliy
dc.contributor.authorMerkulova, Nina
dc.contributor.authorMohylenets, Olena
dc.contributor.authorSolomennyk, Ganna
dc.contributor.authorPopova, Natalia
dc.contributor.authorIvannik, Victoria
dc.contributor.authorMyroshnychenko, Mykhailo
dc.date.accessioned2021-06-12T18:16:38Z
dc.date.available2021-06-12T18:16:38Z
dc.date.issued2021-01
dc.description.abstractThe aim of the study is to reveal in the experiment the morphological features of the infected skin wounds healing, which are a manifestation of acne vulgaris severe and very severe forms, using a gel with carbon dioxide extract of hops. Materials and methods: An experimental study was carried out on 80 male WAG rats of three months of age. The animals were divided into 9 groups. Group 1 consisted of intact animals ( n = 6 ) . Group 2 was represented by animals ( n = 6 ) , which had hair epilation on the dorsal surface of the body in an area of 1 cm2, followed by application of 2 ml of placebo gel to this area. Group 3 included animals ( n = 6 ) , which were epilated on the dorsal surface of the body in an area of 1 cm2 and applied 2 ml of 1 % gel with carbon dioxide extract of hops. Group 4 included rats ( n = 6 ) , which were epilated on the dorsal surface of the body in an area of 1 cm2 and simulated thermal damage. Group 5 was represented by 10 rats, who were epilated on the dorsal surface of the body in an area of 1 cm2, simulated thermal damage, followed by applying 2 ml of placebo gel to the wound surface. Group 6 included rats ( n = 1 0 ) , who underwent measures similar to group 5, followed by application of 2 ml of 1 % gel with carbon dioxide extract of hops to the wound surface. In group 7, there were 6 rats, which were epilated on the dorsal surface of the body in an area of 1 cm2, thermal damage to the skin with underlying soft tissues was simulated, followed by application to the wound surface the reference strainsof Staphylococcus aureus, Streptococcus pyogenes, Proteus vulgaris, Propionibacterium acnes, Escherichia coli, Pseudomonas aeruginosa, Malassezia slooffiae, Malasseziapachydermatis, Candida albicans, Candidaparapsilosis. In groups 8 and 9, there were 15 rats each, which underwent measures similar to group 7, followed by applying 2 ml of placebo gel on its surface on the next day after infection of the wound in group 8, and in group 9 - 2 ml of 1 % gel with carbon dioxide extract hops. The material for the study was the skin with underlying soft tissues. It was used histological, histochemical, morphometric and statistical methods. Results: This experimentally created gel with carbon dioxide extract of hops activates separation processes of horny masses from the surface of the epidermis, cleaning the pores of the skin; stimulating the proliferative activity of the epidermis, which is located in the marginal sections of the wound or covers the surface of the regenerate; activating the processes of cleansing the wound from necrotic tissue; activating the growth and maturation of granulation tissue with its subsequent transformation into connective tissue. It has antiinflammatory, bactericidal and antimycotic effects, normalizing skin microbiocenosis. Conclusions: The complex morphological study has showed that gel with carbon dioxide extract of hops is a highly effective drug in treatment of severe and very severe acne vulgaris, characterized by the development of deep and infected wound defects.en_US
dc.identifier.citationMorphological efficacy evaluation of gel with carbon dioxide extract of hops in case of complicated wound infection acne vulgaris / T. M. Moiseienko, I. I. Torianyk, G. Ye. Khrystian, V. A. Rybak, I. A. Voronkina, A. L. Melnyk, N. F. Merkulova, O. I. Mohylenets, G. O. Solomennyk, N. G. Popova, V. Yu. Ivannik, M. S. Myroshnychenko // Wiadomosci Lekarskie. – 2021. – Tom 74, nr. 1. – P. 112–117.en_US
dc.identifier.otherDOI: 10.36740/WLek202101122
dc.identifier.urihttps://repo.knmu.edu.ua/handle/123456789/28888
dc.language.isoenen_US
dc.publisherAluna Publishingen_US
dc.subjectmorphologyen_US
dc.subjectcomplicated wound infection acne vulgarisen_US
dc.subjectmexperimenten_US
dc.subjectgel with carbon dioxide extract of hopsen_US
dc.titleMorphological efficacy evaluation of gel with carbon dioxide extract of hops in case of complicated wound infection acne vulgarisen_US
dc.typeArticleen_US

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