Кафедра патологічної анатомії
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Item Age features of bone tissue density in the posterior and inferior walls of the frontal sinus(2019) Gargin, Vitaliy; Lupyr, Andrii; Alekseeva, V.; Yurevych, N.Chronic rhinosinusitis is a significant social, medical and economical problem. Elderly patients are unique among all groups of patients. The purpose of our study was to determine physiological variability of frontal sinus in the posterior and inferior walls and to compare it with variability in purulent-polypous rhinosinusitis. Subjects and methods: The study involved SCT examination of 40 male patients: 10 tomograms of patients aged 30–40 and 10 of patients aged 75–85. The tomograms of patients without ENT diseases were used for the control group. The study group included tomograms of patients aged 30–40 and 75–85 with chronic rhinosinusitis. Results. An average bone density of the posterior and inferior walls of the frontal sinuses was alculated. The bone density of the group aged 30–40 was 191.5±11.6 Hu in the inferior wall, 176.6±21 Hu in the posterior and 169.1±16.8 Hu and 164±21 Hu in the group aged 75–85 according to the above order. The study showed pronounced changes in the bone density in purulent-polypous frontal sinusitis. In the group aged 30–40 it was as follows: 120.1±8.3 Hu, 162.1±24 Hu in the inferior wall and 101.4±6.95 Hu, 127.4.8±15.4 Hu in the posterior wall. Conclusions: It can be assumed that the decrease in the bone density is associated with age. And it is more severe in case of chronic frontal sinusitis.Item Anaplasmosis: experimental immunodeficient state model(2019) Bondarenko, A.; Pokhil, S.; Lytvynenko, Marianna; Bocharova, Tetiana; Gargin, VitaliyIntroduction: The recently described anaplasmosis infection is widespread but concerns to the insufficiently known group of diseases. The aim of our research is the development of uniform biological model for reproducing of artificial immunodeficient state by experimental anaplasmosis. Materials and methods: Algorithm of experimental anaplasmosis reproducing, consisted of such consecutive stages: 1) artificial forming of the immunodeficient state at nonlinear white mise (Mus musculus L.); 2) preparation of the tested biological material samples; 3) inoculation by prepared samples of the laboratory animals with the artificially formed immunodeficient state; 4) sampling from the dead or slaughtered (by the method of chloroformed anesthesia) experimental animals of sectional material (organs and targets tissues); 5) verification of aetiology by express detection of causative agents by the method of PCR in the selected samples of sectional material. Results: Biological model of experimental anaplasmosis have been created suitable for realization of both diagnostic and epidemiological, epizootic, ecobiological and other researches of different origin biological material samples, including samples of solid and liquid consistency material. Formed model realised in premature death of experimental animals in 17.4 % cases; resulted in an onset of disease clinical signs without death during the term of supervision in 43.8 % cases; coursed in the absence of the expressed symptoms of infection in 31.3 % cases. Conclusions: Developed biological model of experimental anaplasmosis consists in that as laboratory animals with the increased sensitiveness to the infection and accumulation of causative agent are used white nonlinear mice with the artificially formed immunodeficient state.Item Anaplastic thyroid cancer among other histological thyroid cancer(2013-11-15) Vinnik, J.; Vas’ko, A.; Gargin, VitaliyРабота посвящена гистологическому строению анаплпстического рака щитовидной железы, его структуре среди других гистологических форм, наличию гистологических подтипов.Item Aspects of Physical Activity of Schoolchildren(2017) Bocharova, Maryna; Maya, Naruk; Bocharova, TetianaItem Biopsy-autopsy course (Clinical pathology)(2012) Sorokina, I.; Markovskyi, Volodymyr; Gubina-Vakulyck, Galina; Gargin, Vitaliy; Myroshnychenko, M.; Pliten, O.The book contains the main materials in biopsy-autopsy course according to the syllabus approved by Central Methodological Office for Higher Education of The Ministry of Health of Ukraine. Text-book in Clinical Pathology for English medium medical students is published for the first time in UkraineItem Bone marrow morphofunctional peculiarities in full-term fetuses and newborns from mothers with middle-grade preeclampsia severity(2015-05-14) Galata, D.; Potapov, S.In this absrtact the authors give bone marrow morphofunctional peculiarities in full-term fetuses and newborns from mothers with middle-grade preeclampsia severityItem Cell and tissue damage(кафедра патологической анатомии, 2012) Сорокина, Ирина ВикторовнаItem Cell injury and necrosis : manual for practical classes in pathomorphology for English-speaking medical students(2016-06) Sorokina, I.; Markovskyi, Volodymyr; Korneyko, I.; Gargin, Vitaliy; Gubina-Vakulyck, Galina; Pliten, O.; Myroshnychenko, M.; Potapov, S.; Bocharova, Tetiana; Galata, D.; Kaluzhina, O.Manual for practical classes in pathomorphology for English-speaking medical students on topic " Cell injury and necrosis ".Item Cervical transformation in alcohol abuse patients(2017) Lytvynenko, Marianna; Bocharova, Tetiana; Zhelezniakova, N.; Narbutova, T.; Gargin, VitaliyPatients with alcohol consumption have unclear risk of developing cervical cancer. The purpose of our work was detection of cervical neoplastic transformation in women with alcohol abuse. We investigated 13 cases of cervical neoplastic transformation (5 cases of invasive carcinoma and 8 case of cervical intraepithelial neoplasia (CIN)) which where detected occasionally during autopsy of alcohol abuse women. Microscopic investigation with immunohistochemistry (IHC) was performed indirect to Ki-67, p16. There are some peculiarities in development of cervical cancer in women with alcohol consumption. Level of cellular proliferation is significantly higher with positive staining Ki67 ranged from 29.1% to 89.7% in alcohol abuse group despite ranged from 27.41% to 75.3% in comparison group depend of transformation stage. Simultaneously, positive staining p16 was ranged from 26.2% to 94.8 % in alcohol abuse group despite ranged from 16.1% to 93.7% in comparison group. Diffuse staining with p16, specific gravity of cells with positive IHC reaction with this protein and high reaction intensity can be used as a specific and sensitive method for detecting CIN III and invasive carcinoma in alcohol abuse.Item Characteristics of autopsy material in cases of chronic diffuse pathology of the liver parenchyma diagnosed during patient’s lifetime using the ultrasound method(2020) Fedulenkova, Yuliia; Федуленкова, Юлия Яновна; Федуленкова, Юлія Янівна; Myroshnychenko, Mykhailo; Мірошниченко, Михайло Сергійович; Astapieva, Olha; Астапьева, Ольга; Астап'єва, Ольга Миколаївна; Fatieiev, Aleksandr; Akritova, Kristina; Molodan, Dmytro; Молодан, Дмитро ВолодимировичThe aim: Of the study is to analyze autopsy cases where chronic diffuse pathology of the liver parenchyma was diagnosed during patient’s lifetime using the ultrasound method. In this study archival material (autopsy protocols and microspecimens of these cases) of the pathological anatomy department of the Communal Nonprofit Enterprise «Regional Clinical Hospital» (Kharkiv) was used for the period from 2012 to 2018. The cases diagnosed with a chronic diffuse pathology of the liver parenchyma according to ultrasound data were selected among all cases. Results: The term «chronic diffuse pathology of the liver parenchyma», which is widely used in ultrasound diagnostics, is morphologically a collective term that combines pathological conditions such as fatty hepatosis, fibrosis or cirrhosis of the liver, chronic hepatitis, malignant tumors of the liver, metastatic liver damage and liver infiltration by leukemic cells, liver abscesses. According to the analysis of archival material for the period from 2012 to 2018, there was no change in the relative number of cases with fatty hepatosis, fibrosis or cirrhosis of the liver, chronic hepatitis, malignant tumors of the liver, metastatic liver damage and liver infiltration by leukemic cells, liver abscesses. Among all cases with revealed liver pathology, both separately by year and as a whole for the entire studied period, a predominance of the relative number of cases with fatty hepatosis, fibrosis or cirrhosis of the liver was noted. The ultrasound term «chronic diffuse pathology of the liver parenchyma», taking into account the few cases identified during the analysis where the morphological picture of the liver corresponded to the age norm, needs to be improved, as well as additional diagnostic criteria should be developed in order to correctly use it in practice and avoid diagnostic errors. Conclusions: The term «chronic diffuse pathology of the liver parenchyma», which is widely used in ultrasound diagnostics, is morphologically a collective term that combines pathological conditions such as fatty hepatosis, fibrosis or cirrhosis of the liver, chronic hepatitis, malignant tumors of the liver, metastatic liver damage and liver infiltration by leukemic cells, liver abscesses. The ultrasound term «chronic diffuse pathology of the liver parenchyma» needs to be improved as well as additional diagnostic criteria should be developed in order to correctly use it in practice and avoid diagnostic errors.Item Clinical and Morphological Features of Primary Pulmonary Hypertension: The Analysis of Two Cases from Practice(2017) Sorokina, I.; Kuznetsov, I.; Borzenkova, Iryna; Maslova, Yuliia; Myroshnychenko, M.; Saldan, G.; Levinskiy, V.; Lyubchenko, O.Primary pulmonary hypertension is a rare disease of unknown etiology, which is diagnosed in cases when examination of the patient with high blood pressure in the pulmonary artery does not allow determining its causes. The authors of this article analyze the literature data about primary pulmonary hypertension and report two cases from practice of this pathology. In one case of autopsy of 32-year-old woman primary pulmonary hypertension has been established during the investigation of autopsy material and in another case of autopsy of 52-year-old man this disease has been diagnosed during life. The description of the current state of the problem of primary pulmonary hypertension will be interesting to doctors of any specialization and will also allow to improve of physicians knowledge about this pathology.Item Clinical and morphological features of the ovarian Brenner tumor: current state of the problem(2020) Myroshnychenko, Mykhailo; Мірошниченко, Михайло Сергійович; Dyadyk, Olena; Дядик, Олена Олександрівна; Urzhumov, Victor; Уржумов, Віктор Демьянович; Kapustnik, Natalia; Капустник, Наталія Володимирівна; Капустник, Наталья Владимировна; Borzenkova, Iryna; Борзенкова, Ірина Василівна; Selivanova, Larisa; Torianyk, Inna; Fedulenkova, Yuliia; Kalashnyk, Yulia; Tkachenko, Pavel; Hryhorenko, Varvara; Molodan, Dmytro; Молодан, Дмитро Володимирович; Myroshnychenko, SerhiiOvarian tumours are an actual problem of present-day medicine, being one of the most difficult sections of modern oncology. The majority of ovarian tumours are of epithelial origin. The ovarian Brenner tumour represents a rare epithelial ovarian neoplasm and accounts for 1-2% of all ovarian neoplasms. The aim of the study is to identify clinical and morphological features of ovarian Brenner tumour. The material was 5 cases of Brenner ovarian tumour, diagnosed in the study of 4 cases of operational material and 1 case of autopsy observation for the period from 2007 to 2019. Histological and immunohistochemical staining methods were used. The microspecimens were examined on an Olympus BX-41 microscope (Japan). Ovarian Brenner tumour is a rather rare pathology, the histogenesis of which is debatable. Morphological examination is the main method for its diagnosing. Ovarian Brenner tumours developed in women of middle and old age (the average age was 51.8 years). Women with a malignant ovarian Brenner tumour were older than women with a benign variant (the average age in women with a malignant variant was 55.8 years, with a benign variant – 49.3 years). Benign ovarian Brenner tumour occurred more frequently compared with a malignant one. Malignant and benign variants of ovarian Brenner tumour were characterized by a one-sided nature of the lesion with frequent involvement in the pathological process of the left ovary. Clinically, in patients with a benign variant of the Brenner tumour in all cases an abdominal pain syndrome was determined, combined in one case with metrorrhagia. A malignant ovarian Brenner tumour was clinically manifested by severe abdominal pain syndrome, combined in one case with complaints of an increase in the size of the abdomen, and in another case with intoxication syndrome and a clinic of small bowel obstruction. In all cases a malignant ovarian Brenner tumour metastasized to the omentum and in one case also to the small intestine wall. Macroscopically the ovarian Brenner tumour had the form of a node, the dimensions of which were significantly larger for the malignant variant compared with a benign, dense or soft consistency, on the cross section of a whitish-gray or brown color with cysts. A damaged ovary with a malignant variant of Brenner tumour significantly increased in size, while with a benign one, its size did not change or increased slightly. In all cases the malignant and benign variants of ovarian Brenner tumour were combined with various reproductive system organs pathologies (mucinous papillary cystadenoma of the ovary, serous ovarian cyst, ovarian endometriosis, endometrial hyperplasia, cervical nabothian cysts, uterine leiomyoma). Conclusions: A study conducted by the authors revealed clinical and morphological features of a rare ovarian tumour – Brenner tumour, which will contribute to a better understanding of this pathology by the doctors of various specialties, and improve the treatment and diagnostic process.Item Clinical and pathologic characteristics of testicular germ cell tumors(2019) Potapov, S.; Horhol, N.; Halata, D.; Pliten, O.The performed analyses of incidence rate of testicular germ cell tumors and clinical and pathologic analysis, based on the examination of pathologists’ reports and medical case histories of the patients of Kharkiv regional clinical center of urology and nephrology named after Shapovalov V.I., for the period covering years 1998-2017, revealed: unfavorable increasing tendency in testicular GCT incidences, the most typical age of patients with mentioned pathology, and average duration of the disease by the time the patient visited the doctor; determined the possible risk factors of testicular GCT development, as well as the morphological traits in accordance with WНO updated classification.Item Comparison of cyclophosphamide, doxirubicin and cisplatin action on the male sexual function in experiment(2020-10) Tischenko, M.; Musatova, I.; Prokopiuk, V.; Safonov, E.; Bocharova, Tetiana; Prokopiuk, O.Item The Comprehensive Morphological Criteria for the Diagnosis of Subclinical Bacterial Maternal-Fetal Infection in Offspring(2021) Talapova, Polina; Sorokіna, Iryna; Markovskyi, Volodymyr; Tovazhnianska, Vira; Sakal, Anna; Zvierieva, IrynaThe paper presents study materials devoted to determining the morphofunctional state of progeny’s organs developed under subclinical bacterial maternal-fetal infection (MFI) in order to define the comprehensive diagnostic criteria of this pathology. The rat models of subclinical MFI caused separately by E. coli, S. aureus, and K. pneumoniae were used, the set of diagnostic tools (histopathological staining of paraffin sections of aorta (AO), pulmonary artery (PA), thyroid (TG), and adrenal glands (AG), liver (LV) of fetuses with H&E, Mallory’s trichrome and Van Gieson's methods, optical microscopy, morphometry, and immunofluorescence with the use of ImageJ software) was applied. Statistical analysis was performed in Microsoft Excel 365 and R. Depending on the organ, the null hypothesis was rejected when p<0.05 or p<0.001. The assemblage of statistically significant diagnostic parameters of the subclinical MFI damaging effect in offspring’s organism was determined: for AO and PA – endotheliocyte’s height, the optical density of fluorescence (ODF) of CD34-positive cells, type III and IV collagens; for TG – thyrocyte’s height, nuclear-cytoplasmic ratio (NCR), follicle’s square, T4 OD; for AG – adrenocorticocytes’ density in zona glomerulosa, adrenocorticocyte’s NCR, cortisol ODF in zona fasciculata; for LV - hepatocytes’ density, NCR, the absolute number of IL-6 producing cells. Conclusion: in this study, we have proved the presence of pathomorphological substrate and defined dynamics of morphofunctional changes forming in the fetal organism under the bacterial MFI that enables the use of obtained values as diagnostic criteria of this pathology.Item Confocal microscopy of periodontal tissue in intrauterine growth retargation(2013-12-10) Назарян, Розана Степановна; Гармаш, Ольга Владимировна; Гаргин, Виталий Витальевич; Чернявсий, Александр ДмитриевичНами исследован пародонт новорожденных крысят с экспериментальной моделью ЗВУР. Световая микроскопия выявила уменьшение сосудистой плотности. Состояние сосудистого русла характеризовалось наличием как спазмированных, так и дилатационно расширенных сосудов. Эндотелиоциты уплощены с признаками десквамации. Отмечается наличие кровяных свертков. Периваскулярное пространство характеризуется наличием начальных склеротических процессов. Результаты проведенного исследования свидетельствуют, о том, что конфокальная микроскопия является наиболее информативным методом визуализации тканей.Item Degeneration(Кафедра патологической анатомии, 2012) Сорокина, Ирина ВикторовнаItem Diseases of hematopoietic system. Atherosclerosis. Ischemic heart disease. Hypertension. Systemic diseases of connective tissue with immune disturbances : manual for practical classes in pathomorphology for English-speaking medical students(2016-06) Sorokina, I.; Markovskyi, Volodymyr; Korneyko, I.; Gargin, Vitaliy; Gubina-Vakulyck, Galina; Pliten, O.; Myroshnychenko, M.; Potapov, S.; Bocharova, Tetiana; Galata, D.; Kaluzhina, O.Manual for practical classes in pathomorphology for English-speaking medical students on topic " Diseases of hematopoietic system. Atherosclerosis. Ischemic heart disease. Hypertension. Systemic diseases of connective tissue with immune disturbances ".Item Diseases of the respiratory system, gastrointestinal tract, liver, gallbladder, pancreas and endocrine glands(2016-06) Sorokina, I.; Markovskyi, Volodymyr; Korneyko, I.; Gubina-Vakulyck, Galina; Gargin, Vitaliy; Pliten, O.; Myroshnychenko, M.; Potapov, S.; Bocharova, Tetiana; Galata, D.; Kaluzhina, O.Методические рекомендации для англоязычных студентов для практических занятий при разборе патологии печени, желчного пузыря, поджелудочной железы, органов дыхания и эндокринной системы.Item Disturbance of blood and lymph circulation. Infraction of tissue fluid. Inflammation. Diseases of the immune system. Compensatory adaptation pro-cesses. Repair : manual for practical classes in pathomorphology for English-speaking medical students(2016-06) Sorokina, I.; Markovskyi, Volodymyr; Korneyko, I.; Gubina-Vakulyck, Galina; Gargin, Vitaliy; Pliten, O.; Myroshnychenko, M.; Potapov, S.; Bocharova, Tetiana; Galata, D.; Kaluzhina, O.Manual for practical classes in pathomorphology for English-speaking medical students on topic " Disturbance of blood and lymph circulation. Inflammation. Diseases of the immune system. Compensatory adaptation pro-cesses. Repair ".