Browsing by Subject "cardiovascular complications"

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Effect of leptin lep – 2548 g > a (rs7799039) and leptin receptor lepr 223 q > r (rs1137101) gene polymorphic variants on the development of cardiovascular complications in patients with type 2 diabetes mellitus
(2022-12-15) Mamontov, Ivan; Plohotnichenko, O.; Krasova, N.; Kolesnikova, A.; Gorshunska, M.; Pochernyaev, A.; Voropay, T.; Romanova, I.; Karachentsev, Yu.; Роltorak, V.
The polymorphism -308 G/A of the TNF gene and metabolic imbalance in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease, taking into account cardiovascular complications
(ДУ "Інститут проблем ендокринної патології ім. В.Я. Данілевського АМН України", 2023-07) Tyzhnenko, T.; Misiura, K.; Kravchun, N.; Gorshunska, M.; Pochernyaev, A.; Krasova, N.; Gladkih, O.; Leshchenko, Z.; Fedorova, G.; Plohotnichenko, O.; Hromakovska, O.; Kolesnikova, A.; Jаnsen, E.; Karachentsev, Yu.; Роltorak, V.
Non-alcoholic fatty liver disease (NAFLD), the most common form of liver disease, is now recognized as a major public health problem worldwide. Tumor necrosis factor alfa (TNF-α), a member of the TNF/TNFR cytokine family, is an intercellular transmission molecule that has been reported in a wide range of human noninfection diseases. The aim of the study was to determine the circulating levels of TNF-α and the nature of its relationships with the components of insulin resistance, both metabolic and hormonal, in patients with type 2 diabetes; and establishing the nature of cardiovascular complications (taking into account TNF-α gene polymorphism) in the presence and absence of NAFLD. Materials and methods. Case-control study included information about 50 practically healthy people from the city of Kharkiv and the region. The examined population (except control subjects) consisted exclusively of patients with type 2 diabetes mellitus with a long-term existence of the disease against the background of metabolic syndrome, with varying degrees of glycemic control and violations of liver homeostasis in the absence of renal failure. 117 people were selected for analysis: 63 of them with type 2 diabetes in the presence of NAFLD and 54 patients with type 2 diabetes without NAFLD. Genotyping for single nucleotide polymorphism -308 G > A of the TNF-α was performed by the method of polymerase chain reaction with appropriate primers and NcoI endonuclease. Testing of statistical hypotheses was carried out using the odds ratio and χ2 criteria at the significance level of P ≤ 0.05. Results. The contribution of the genetic component to the formation of the predisposition to the development of type 2 diabetes mellitus based on the single-nucleotide polymorphism -308 G > A of the TNFα gene was determined, which makes it possible to consider the carrier of the A allele as a factor of increased risk for the development of type 2 diabetes mellitus. No association of the studied polymorphism with the risk of developing NAFLD was found. The obtained data make it possible to assume that the studied polymorphism -308 G > A of the TNFα gene is more associated with the risk of developing type 2 diabetes, and the occurrence or progression of NAFLD primarily depends on metabolic imbalance, and not on the contribution of the studied polymorphism. Conclusions. Non-alcoholic fatty liver disease is closely related to hormonal and metabolic risk factors and markers of cardiovascular disease and type 2 diabetes and may increase the risk of developing and progressing cardiovascular complications. The contribution of the genetic component to the formation of the predisposition to the development of type 2 diabetes mellitus based on the single-nucleotide polymorphism -308 G > A of the TNFα gene was determined, which makes it possible to consider the carrier of the A allele as a factor of increased risk for the development of type 2 diabetes mellitus.
Role of plasma 8-OXO-2’-deoxyguanosine in target organ damage in patients with hypertension and type 2 diabetes
(2022) Zhelezniakova, Natalia; Shalimova, Anna; Nemtsova, Valeriya; Kolesnikova, Olena; Vysotska, Olena; Zlatkina, Vira
Background: The aim of the study was to determine the prognostic value of 8-oxo-2’-deoxyguanosine (8-OHdG) plasma levels for cardiovascular complications (CVC) development in hypertension (HTN) and type 2 diabetes mellitus (T2DM) comorbidity. Material and methods: One hundred fifty-six patients (mean age 61.71 ± 0.87 years) with the combined course of HTN stage II and T2DM (group 1) and 100 non-diabetic patients with HTN stage II (mean age 60.59 ± 0.87 years, group 2) were examined. Lipid, carbohydrate metabolism, plasma insulin, plasma 8-OHdG (by ELISA), blood pressure levels were measured. Observation period was 12 months. Results: Plasma levels of 8-OHdG in the patients’ groups were significantly higher than in the controls (p < 0.001), in the group 1 higher than in group 2 (15.37 ± 0.27 ng/L vs. 14.00 ± 0.29 ng/L, respectively, p = 0.002). Plasma levels of 8-OHdG in group-2 patients who developed cardiovascular complications during observation period were significantly higher than in those without cardiovascular complications (16.47 ± 0.62 ng/L vs. 15.11 ± 0.29 ng/L, respectively, p = 0.046). The ROC analysis made it possible to propose the 8-OHdG plasma level ≥ 15.68 ng/L as an identifier for the cardiovascular complications in patients with studied comorbidity. In group 1, in patients with 8-OHdG plasma level ≥ 15.68 ng/L such cardiovascular risk factors as total cholesterol (TC) (p = 0.034), low density lipoprotein cholesterol (LDL-C) (p = 0.035), systolic blood pressure (p = 0.022), HOMA-IR (p = 0.046) were significantly higher compared with those whose level of this indicator was < 15.68 ng/L. Conclusion: Determination of the plasma 8-OHdG allows not only for assessment of the severity of oxidative stress, but also for determination of the course and prognosis in comorbidity of HTN and T2DM.
The cardiovascular complications and risk factors in cardiac patients with type 2 diabetes
(2016) Bilovol, Olexandr; Bobronnikova, Lesya; Ilchenko, Iryna
The results of the analysis indicate that patients with hypertension and CHD with DM-2 have more RF and CVC. Accompanying illnesses are very common in these patients, and modiﬁable risk factors, including hypertension, DM-2. Psychosocial stress should be considered as one of the main directions for the best results from the treatment and prevention of CVC.
Експресія протеїназ вазоконстрикторної дії в дітей із різними формами бронхолегеневої дисплазії
(2012) Сенаторова, Ганна Сергіївна; Черненко, Лариса Миколаївна; Самохіна, Любов Михайлівна
У статті наведені результати аналізу рівнів протеїназ вазоконстрикторної дії в дітей із різними формами бронхолегеневої дисплазії. Показано, що система протеїназа-інгібітор протеїназ відіграє істотну роль у виникненні кардіоваскулярних ускладнень при бронхолегеневій дисплазії.