Browsing by Subject "adipokines"

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Adipokines activity and cardiometabolic risk factors in patients with arterial hypertension
(2012) Kovalyova, Olga; Zlyvka, Larisa
Adipokines and interleukin-17 are the link of regulatory mechanism in kidney
(2018-09-28) Goncharova, Аlina
Adipokines and interleukins (IL) are involved in regulation of renal function but their role in the mechanisms is not clear yet. If the effects of such adipokine as adiponectin in kidney disorders are better defined [1], the effects of visfatin and IL17 are not so well studied.
Adipokines and lipid profile changes in nonalcoholic fatty liver diseases patients
(2017) Lapshyna, Kateryna; Bashkirova, Anna; Zakharenkova, A.
Abnormal secretion of adipokines may play a key role in the development of metabolic syndrome, including non-alcoholic fatty liver disease (NAFLD) and progression of nonalcoholic steatohepatitis (NASH). Excessive visceral adipose tissue was identified as one of the main causes leading to the development of NAFLD.
Adipokines in patients with hypertensive disease with obesity in the dynamics of combined antihypertensive therapy
(2021) Kravchun, Pavlo H.; Kadykova, Olga; Herasymchuk, U.; Кравчун, Павло Григорович; Кадикова, Ольга Ігорівна; Герасимчук, Уляна Сергіївна
Adipokines, glucometabolic disorders, abdominal obesity in hypertensive patients
(2012) Ashcheulova, Tetyana; Ambrosova, Tetyana
Carbohydrate and lipid disorders and adipokines levels in relation to body mass index in hypertensive patients
(Revista Mexicana de Cardiología, 2018) Ashcheulova, Tetyana; Demydenko, Ganna; Ambrosova, Tetyana; Kysylenko, Kateryna; Gerasimchuk, Nina; Kochubiei, Oksana
Obesity is considered as a valid risk factor for cardiovascular disease, due to the fact that the risk of morbidity and mortality from various causes in obese people is signifi cantly higher. Exact mechanisms of metabolic disorders in hypertension with obesity is still discussible. The aim of the study – to determine the peculiarities of carbohydrate, lipid metabolism changes and activity of adipokines and interleukin-22, in patients with hypertension according to nutritional status. Methods: 80 patients (37 males and 43 females) with essential hypertension (EH) of average age 60.17 years were examined. Carbohydrate, lipid profi les, apolipoprotein B (apo B), tumor necrosis factor-α (TNF-α), plasminogen activator inhibitor-1 (PAI-1), adiponectin, interleukin-22 (IL-22) were estimated. Results: In patients with EH and obesity was found carbohydrates metabolism abnormalities, that was manifested as hyperinsulinemia, glucose and HbA1c levels elevation and insulin resistance (according to HOMA index). Lipid metabolism disorders were observed as valid increasing of triglycerides and apo B. Body mass index elevation was associated with progressive increasing of TNF-α and PAI-1 concentration with reducing of adiponectin level in the patients with EH. Positive relationships between TNF- and HbA1c, apo B; PAI-1 with glucose levels: negative correlation adiponectin with body mass and waist to hip ratio were detected in the patients with obesity associated (BMI ≥ 30 kg/m2) EH. Positive signifi cant correlations between apo B and insulin levels, HOMA index, and TNF-α concentration were defi ned. IL-22 in overweigh and obese patients was signifi cantly higher, correlates negatively with HDL-C. Conclusion: In patients with EH and obesity the adipokine dysfunction was revealed, that correlates with carbohydrate and lipid parameters that indicate increased proinfl ammatory and prothrombogenic processes.
Diagnostic aspects of acute myocardial infarction in patients with obesity and diabetes mellitus of type 2
(2018) Котелюх, Марія Юріївна; Koteliukh, Mariia
The article discusses the development of acute myocardial infarction with obesity and type 2 diabetes melli- tus. The pathophysiological roles of new adipokines and proteins are described - energy homeostasis in acute myocardial infarction with the presence of obesity and type 2 diabetes mellitus.
Formation process of motor-evacuatory disorders in patients with gastroesophageal reflux disease and concomitant obesity
(Gastroent Hepatol, 2017) Korniienko, Daria; Oparin, Alexey
The research had shown that patients with isolated GERD and patients with GERD and concomitant obesity had different mechanisms that lead to the disruption of the lower esophageal sphincter. GERD patients with concomitant obesity had chronic inflammatory process in adipose tissue, which leads to reduction of protective adipokine (adiponectin) level and increase of inflammatory adipokine (visfatin) level. The patients with isolated GERD had prevalence of the parasympathetic nervous system and increased aggression of gastric juice.
The influence of adipokines imbalance on course of osteoarthritis in patients with type 2 diabetes mellitus and obesity
(2020) Zhuravlyova, Larysa; Oliinyk, Mariia; Sikalo, Yuliia
The aim of the study was to investigate the level of leptin, resistin and their connection with high sensitive C-reactive protein and clinical manifestation of osteoarthritis in patients with type 2 diabetes mellitus and obesity.
Interactions of RANKL, osteoprotegerin and adipokines in regulation of bone remodeling in experimental chronic kidney function disorder
(Georgian Medical News, 2018-08) Goncharova, Аlina; Pavlov, S.; Kumetchko, M.; Berezniakova, M.; Yeriomenko, R.
RANKL and osteoprotegerin are the key cytokines of the axis regulating not only bone remodeling but also bone-kidney in- terrelations. They are connected with adipokines in the regulatory actions. The aim of the article was to investigate the role of the main parts of RANK-RANKL-osteoprotegerin axis and cytokines of additional link of regulatory network – adiponectin and visfatin and the interrelationship of these cytokines in chronic kidney disorder model in rats. Chronic kidney disorder model was created in the rats 12 weeks after intramuscular 50 % glycerol injection-induced acute kidney injury. RANKL, osteoprotegerin, adiponectin and visfatin levels was measured using ELISA. Increase of all cytokines and changes of their interrelations has been revealed in rats with chronic kidney disorder model. Conclusion was made that effects of the cytokine axis where RANKL is a trigger in the regulation network of intercon- nections «bone – kidney» has inflammatory character, so as visfatin effect, and adiponectin has opposite preserving bone effect.
Interrelations between adipokines and interleukin-17 as the links of regulatory mechanism in kidney function disorder model in rats
(2019-03-28) Goncharova, Аlina; Kyrychenko, Michael; Dunaieva, Olha; Shenger, Svetlana
Adipokines and interleukins (IL) are involved in regulation of renal function but their role in the mechanisms is not clear yet. If the effects of such adipokine as adiponectin in kidney disorders are better defined, the effects of visfatin and IL-17 are not so well studied. Also it is very important to understand interrelations between main adipokines in the regulatory network.
Predictors of hormonal and metabolic disorders of arterial hypertension and type 2 diabetes mellitus comorbidity
(2017) Bilovol, Olexandr
These experiments studied adipokine and interleukin imbalances during the development and progression of metabolic disorders in patients with arterial hypertension (AH) and type 2 diabetes mellitus (T2DM).
Significance of metabolic parameters in patients with type 2 diabetes mellitus and chronic pancreatitis in forecasting the level of vaspin
(2020) Pylov, Daniel
Adipokines are closely associated with the development of diseases and conditions such as type 2 diabetes mellitus, dyslipidemia, hypertension, atherosclerosis and inflammation, as they contribute to the development of insulin resistance, metabolic disorders, stimulate local inflammation and may affect atherogenesis process. Vaspin, a new serine protease inhibitor produced by visceral adipose tissue is an adipokine with insulin-sensitive and anti-inflammatory properties and has angio- and cardioprotective effects.
The influence of resistin on liver function in patients with diabetes mellitus type 2 and obesity
(2013) Zhuravlyova, Larysa; Ogneva, Olena
Resistin is an adipokine that can cause the proinflammatory effects in star-like liver cells, which are the key modulators of fibrosis. There is a need in further study of resistin effects on liver function and its role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) against the background of metabolic disorders.
Оценка факторов кардиометаболического риска у пациентов с неалкогольной жировой болезнью печени
(2013) Журавлева, Лариса Владимировна; Бобронникова, Леся Романовна
В работе представлен анализ результатов факторов кардиометаболического риска у пациентов с неалкогольной жировой болезнью печени и метаболическим синдромом. У таких больных поражение органов-мишеней обусловлено прогрессированием метаболических нарушений в печени, инсулинорезистентностью, ожирением, нарушениями липидного и углеводного обменов, развитием системного воспаления и субклинических признаков атеросклероза, которые находятся во взаимосвязи с дисбалансом адипоцитокинов и избыточным накоплением висцеральной жировой ткани, что способствует развитию высокого кардиометаболического риска у данной категории больных. В роботі представлено результати аналізу факторів кардіометаболічного ризику у пацієнтів з неалкогольною жировою хворобою печінки і метаболічним синдромом. У таких хворих ураження органів-мішеней обумовлено прогресуванням метаболічних порушені в печінці, інсулінорезистентністю, ожирінням, порушеннями ліпідного і вуглеводного обмінів, розвитком системного запалення та субклінічних ознак атеросклерозу, які знаходяться у взаємозв’язку з дисбалансом адипоцитокінів і надлишковим накопиченням вісцеральної жирової тканини, що сприяє розвитку високого кардіометаболічного ризику у даної категорії хворих. Article presents the result of evaluation of cardiometabolic risk factors in patients with nonalocoholic fatty liver disease and metabolic syndrome. The organs damage in this patients caused by the progression of metabolic disorders in the liver, insulin resistance, obesity, lipid and carbohydrate metabolism and the development of systemic inflammation and subclinical atherosclerosis who correlate with the imbalance of adipocytokines and excessive accumulation of visceral adipose tissue.
Фактори формування метаболічного синдрому у пацієнтів з неалкогольною жировою хворобою печінки
(2013) Боброннікова, Леся Романівна
В статье представлены результаты исследований 45 пациентов с неалкогольной жировой болезнью печени с нормальной массой тела и абдоминальным ожирением. Установлено, что течение НАЖБП и АО сопровождается ранним формированием метаболического синдрома, обусловленного дислипидемией, гиперинсулинемией, инсулинорезистентностью и развитием системного воспаления, а также дисбалансом адипоцитокинов, характеризующемуся повышенным уровнем лептина, фактора некроза опухолей-α и сниженным уровнем адипонектина. В статті представлені результати обстеження 45 пацієнтів з неалкогольною жировою хворобою печінки з нормальною масою тіла та абдомінальним ожирінням. Встановлено, що перебіг неалкогольної жирової хвороби печінки та абдомінального ожиріння супроводжується раннім формуванням метаболічного синдрому, обумовленого дисліпідемією, гіперінсулінемією, інсулінорезистентністю і розвитком системного запалення, а також дисбалансом адипоцитокінів, що характеризується підвищеним рівнем лептину, фактору некрозу пухлин-α і зниженим рівнем адипонектину. The article presents the results of examination of 45 patients with nonalcoholic fatty liver disease with normal body mass and abdominal obesity. It is set, that the nonalcoholic fatty liver disease and abdominal obesity accompanied the early formation of the metabolic syndrome caused dyslipidemia, hyperinsulinemia, insulin resistance and the development of systemic inflammation, as well as an imbalance of adipocytokines, characterized by elevated levels of leptin, TNF-α and decreased levels of adiponectin.