Browsing by Subject "body mass index"

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An Imbalance of the hormones of fatty tissue in patients with type 2 diabetes mellitus depending on body mass index
(2017) Zhuravlyova, Larysa; Ogneva, Olena; Lavrynenko, Olga
Purpose. The study was designed to assess the level of resistin and tumor necrosis factor-alpha (TNF-α) and its relationship with body mass index (BMI) in patients with type 2 diabetes mellitus (DM-2) with normal body weight and obesity.
Apelin – additional marker of insulin resistance
(2015) Журавльова, Лариса Володимирівна; Шеховцова, Юлія Олександрівна; Zhuravlyova, Larysa; Shekhovtsova, Yuliia
Summary: The purpose of the present study was to determine the correlations between the state of carbohydrate metabolism and concentrations of apelin in blood of patients with type 2 diabetes mellitus with different phenotypes. Materials and methods. A total of 32 patients with type 2 diabetes mellitus with different phenotypes (13 men, mean age 56,77 ± 1,79 years) were examined. The control group included 20 healthy individuals. Results. The significant elevation of adipocytokine apelin level was found. The significant correlations between body mass index, apelin and the parameters of carbohydrate metabolism were defined. Conclusions. Increased levels of apelin and connection between this adipocytokine and anthropometric parameters as well as indices of carbohydrate metabolism suggests that elevated body weight contributes to activation and strengthening of impact mechanisms of adipose tissue hormones on metabolic status
Body mass index as one of the markers of metabolic processes in bioequivalence studies
(KhNMU, 2016-05) Zupanets, I.; Karnaukh, Ella; Filyanin, S.
Cardiovascular changes in humanbody after changing position supine to prone
(2019-04) Лизогуб, Микола Віталійович; Lyzohub, Mykola; Georgiyants, M.; Vysotska, O.; Porvan, A.; Lyzohub, Kseniia
UkraineProne position is known to be accompanied by several physiologic changes, but they are not described comprehensively in modern literature and sometimes controversial.Aim was to examine cardio-vascular changes in non-anesthetized humans after turning them into prone position and influence on these changes by age and body mass index.We performed an observational prospective study without control group of 200 (118 male and 82 female) patients 18-75 y.o. The patients were examined the day before elective lumbar spine surgery using thoracic electrical bioimpedance and non-invasive measurement of blood pressure in supine position (SP), 5 min and 20 min after turning into prone position (PP5 and PP20).Diastolic BP increased significantly after turning (PP5) and stayed increased during the time of investigation (PP20). Stroke volume index (SVI) decreased after turning into prone position (PP5 and PP20) by 18%. Systemic vascular resistance index (SVRI) increased by 34% (PP5). The duration of asynchronous contraction phase increased by 35% and the duration of all ejection phases decreased after changing the position from supine to prone. Rapid ejection reduced by 30%, reduced ejection – by 7%. We found the influence of age >60 y.o. on increasing of SVRI (p=0.006) and influence of age > 60 y.o. and BMI > 25 on decreasing of SVI (p=0.01 and p=0.04 respectively).In healthy non-anesthetized people turning from supine to prone position leads to decreasing of SVI by 18%, increasing of SVRI by 34% and increasing of diastolic blood pressure increased by 7%. Changes of SVRI are influenced by age and changes of SVI are influenced by age and BMI. Positioning prone are accompanied by shortening of both ejection periods and prolonging of asynchronous contraction period.
Correlation between body mass index and indices of diastolic function in patients with type 2 diabetes mellitus
(2013) Sokolnikova, Nelia; Rashad, Salameh
Type 2 Diabetes mellitus (DM2) is a proven risk factor for development of metabolic cardiomyopathy. The majority of patients with DM2 have an elevated body mass index which is a risk factor for development of cardiovascular diseases. However, the relationship between the development of diabetic cardiomyopathy as a primary myocardial injury in DM2 and an elevated body mass index in patients with DM2 has not been yet thoroughly studied
Pathogenetic advances of fosinopril sodium with hydrochlorothiazide in obese hypertensive patients
(2017-10) Ashcheulova, Tetyana; Gerasimchuk, Nina; Rezunenko, Y.; Demydenko, Ganna; Kochubiei, Oksana
Essential hypertension (EH) stays the important public challenge, because of leading positions in morbidity and mortality in not only Ukraine, but also worldwide. This number is predicted to increase 1.5 billion by 2025. Unfortunately half of that population is unaware of present hypertension [20]. Numerous clinical studies have established the relationship of high blood pressure with increasing body weight. In particular, in the INTERSALT study, carried out in 52 population groups, showed direct correlation between body mass index (BMI) and elevated blood pressure [21]. In Hypertension Control Program was found that 50% of surveyed middle-aged overweight have hypertension (EH), and 2/3 cases of the hypertension are associated with obesity [27]. Framingham study showed that 78% of men and 65% of women has hypertension and are obese [14]. Data confirmed by Swedish Obesity Study [28] where 44-51% of individuals with obesity have essential hypertension. Consequently, increasing in body weight is a potential risk factor for essential hypertension. Finally, the term "obesity induced hypertension" appears. Obesity-associated hypertension is a multicomponent process, and the pathogenesis includes increasing in circulating blood volume, vasoconstriction, hyperreactivity of sympathetic and renin-angiotensin-aldosterone system (RAAS), prediabetes, dyslipidemia and other metabolic disorders. Investigations of the last decade showed that one of the early phases of the pathogenesis of this comorbid pathology is the development of endothelial dysfunction (ED). Elevated levels of angiotensin secreted by the adipocytes, is an important link between visceral obesity and ED, as proved by the correlation of waist - to - hips ratio with the level of mRNA angiotensinogen in visceral and subcutaneous adipose tissue. The subsequent increasing of angiotensin II tissue level stimulates the secretion of superoxide that is known as leading - factor in the etiology of ED. Currently, leading role of the endothelium and nitric oxide in the pathogenesis of cardiovascular complications of hypertension is proved [24, 18, 19]. The leading role in reducing endothelium-dependent vasodilation belongs to the intracellular oxidative stress (OS) as free radical oxidation dramatically reduces the production of NO by endothelial cells [6,1]. Endothelial dysfunction and OS are becoming the new therapeutic targets in the treatment of hypertensive patients. It should be noted that the analyses of pharmacological properties of antihypertensive drugs pay little attention to this aspect. According to some researchers, OS can be a promotor of proinflammatory cytokines system activation. Among the pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) deserves particular attention in context of hypertension [1,2,7,16,17,29]. Thus, Zahorska-Markiewiez [30] was found in blood of patients with essential hypertension increased content of C-reactive protein (CRP) and TNF-α. It hemodynamic stress caused by hypertension, is stimulus of increased release into the blood of proinflammatory cytokines, including TNF-α [10,15] which, in turn, can modulate the structure and function of the cardiovascular system. The most important predisposal for the maximum reduction in cardiovascular risk in hypertension is achieving the target BP, which may be a problem in presence of overweight and obesity. In many cases there is a need in combination of two antihypertensive drugs that should be metabolically neutral [8,25]. Thus, the scientific justification of treatment regimens in hypertensive patients with overweight and obesity, the study of the antioxidant efficacy of combined antihypertensive therapy is extremely relevant and important for today’s practical healthcare. Despite the large number of antihypertensive drugs and the scientific study of the principles of treatment of patients with hypertension, it would be a mistake to assume that the problem is completely solved.
Relationship leptin and body mass index in patients with diabetes mellitus type 2
(2012) Sokolnikova, Nelia
Overweight plays an important role in the development of cardiovascular complications in patients with diabetes mellitus type 2 (DM-2). The risk of acute complications (myocardial infarction, stroke) increases along with the body weight gain. Leptin is a hormone produced by adipose tissue. Experimental and clinical studies indicate various negative effects of leptin and leptin resistance
Role interleukin 18 in the course and progression of osteoarthritis in patients with obesity
(2022) Litvynova, Anastasiia; Літвінова, Анастасія Михайлівна
musculoskeletal disorders are an extremely common pathology. They are the most common cause of chronic pain and disability: every minute, more than 30% of adults suﬀer from joint pain or limited physical activity. These diseases signiﬁcantly aﬀect the psychosocial status of patients, their families, and caregivers. The course of joint diseases leads to loss of mobility, social autonomy; such patients have higher rates of hospitalization and mortality. That is, the quality of life signiﬁcantly deteriorates, and the ﬁnancial costs of health care for patients and society increase. It is proved that one of the predictors of arthrosis is overweight. In the pathogenesis of osteoarthritis and obesity, proinﬂammatory cytokines play an important role, the excess synthesis of which leads to the progression and chronicity of the process. Therefore, the aim of our study was to determine the dependence of interleukin-18 activity in patients with osteoarthritis, which occurs on the background of obesity and without it. The study presents the study of interleukin-18 in 75 people with osteoarthritis (OA), which occurred on the background of obesity (main group), and 50 patients with isolated OA (comparison group). The control group consisted of 37 healthy individuals. The diagnosis of OA was established based on the order of the Ministry of Health of Ukraine of 12.10.2006 “On medical care for patients with osteoarthritis”, uniﬁed diagnostic criteria of the Association of Rheumatologists of Ukraine (2004), and the criteria of the American College of Rheumatologists. The presence and severity of obesity were assessed according to the criteria of the International Diabetes Federation (IDF, 2005) based on the calculation of body mass index (BMI) according to the Kettle formula. When determining the level of IL-18 in the main group, it was found that the content of this cytokine was almost two times higher than the reference values (p <0.05). In the comparison group, the activity of IL-18 increased 1.6 times (p <0.05). Comparison of the content of IL-18 between the study groups allowed us to determine its increase in the presence of obesity by almost 1.2 times. The increase in IL-18 content depended on the radiological stage of joint damage: the maximum value was recorded in patients of the main group with stage 2 symptoms. Apparently, such results are a consequence of the predominance of the inﬂammatory reaction in the progression of the pathology due to the comprehensive involvement of extra-articular components (ligaments, tendons, bags, etc.). Slightly lower levels of IL-18 in stage 1 OA are likely to be due to the involvement of a limited portion of joint tissue, while the 3rd radiological stage is characterized by a predominance of dystrophic processes. In patients with osteoarthritis, an increase in the content of IL-18 in the serum is determined, which is associated with the development of the inﬂammatory process in the components of the joint. The content of IL-18 has a direct correlation with overweight / obesity and the radiological stage of the process in the joints. Increased proinﬂammatory cytokine IL-18, which is a component of the immune system and simultaneously synthesized by adipocytes of adipose tissue, can be considered a factor that will contribute to the preservation of chronic pain and progression of the pathology. Dynamic control of IL-18 activity should be used as an indicator of the eﬀectiveness of therapy.
The role of diabetes mellitus 2 type of asthma course
(2020-05) Yeryomenko, Galyna; Iliucha, Sergey
Background: combination of bronchoobstructive diseases and metabolic disorders is under a great interest of scientists. Diabetes mellitus (DM) is not only associated with abdominal obesity, arterial hypertension, cardiovascular disorders but also associated with deterioration of pulmonary function, particularly decreasing of forced expiratory volume-1-second (FEV1).
The role of matrix metalloproteinase-9 in the course of osteoarthritis in patients with obesity
(sci-conf.com.ua, 2022-11-08) Pasiyeshvili, L.; Пасієшвілі, Людмила Михайлівна; Litvynova, A.; Літвинова, Анастасія Михайлівна; Didenko, K.; Діденко, Катерина Андріївна; Hadirova, T.; Хадирова, Турчан
The role of matrix metalloproteinase-9 in the course of osteoarthritis in patients with obesity
Structural and functional state of bone tissue in young people with a combined course of osteoarthritis and obesity
(2022) Litvynova, Anastasiia; Літвінова, Анастасія Михайлівна
n recent years, an increase in the number of patients with osteoarthritis (ОА) against the background of obesity is considered not from the point of view of mechanical stress on the joints by an overweight patient but by the active synthesis of hormone-like substances by adipose tissue, which have a metabolic eﬀect on all processes in the body. A large number of diﬀerent chemical compounds (calcium, phosphorus, magnesium, uronic acids, tartrate-resistant bone phosphatase, and a number of others) are involved in the remodeling of bone tissue, the balance between which determines the strength and mobility of the bone. Among such biochemical markers, the glycoprotein osteoprotegerin is considered. The osteoprotegerin inhibits the diﬀerentiation of osteoclast precursors into osteoclasts and also regulates their resorption in vitro and in vivo. It works by binding to RANKL on osteoblast / stromal cells, thereby blocking the RANKL-RANK ligand interaction between osteoblasts / stromal cells and osteoclast precursors. The aim of our study to establish the content of osteoprotegerin in the blood serum of young patients with osteoarthritis and obesity and to analyze its role in the formation of structural and functional changes in bone tissue. The work was performed on 75 young patients (average age - 30.92 ± 0.55 years) with OA, which was established in patients with various stages of obesity; for the comparison group, 50 individuals with an isolated course of OA of the same age (30.95 ± 0.55 years) and duration of anamnesis were selected; control indicators were obtained when examining 37 apparently healthy individuals. The diagnosis of OA was conﬁrmed by a comprehensive assessment of patients’ complaints, anamnesis data, objective and instrumental studies (X-ray examination of the aﬀected joints) while focusing on the “Protocols for the management of patients with osteoarthritis.” The presence and severity of obesity were assessed according to the criteria of the International Diabetes Federation (IDF, 2005) based on the calculation of body mass index (BMI) according to the Kettle formula. The indicator of osteoprotegerin (pg / ml) (bone tissue glycoprotein) was investigated in fasting blood serum by enzyme-linked immunosorbent assay (ELISA) using FineTest EH0247 reagents, China. The prevalence of osteoporotic conditions was assessed by dual-energy X-ray absorptiometry (DEXA) using the HOLOGIC Explorer QDR W Series Bone Densitometer (USA). The content of osteopro-tegerin in blood serum was studied as a biochemical marker of damage to the bone and cartilage tissue. The data obtained allowed us to say that in both groups - patients with OA (92.3 ± 1.68 pg / ml) and patients with a combination of OA with obesity and increased body weight (124.03 ± 3.2 pg / ml) - there was an increase in this glycoprotein when compared with the control values (65.64 ± 0.64), (p <0.001). The performed densitometric study allowed us to obtain the following results: osteopenia was identiﬁed in 15% of patients in main group and in 36% - in comparison group; osteoporosis was identiﬁed in 24% of patients in main group and in 10% - in comparison group.The course of osteoarthritis in young people is accompanied by the formation of osteoporotic conditions, which more often (24% versus 10%), with the addition of obesity, lead to the development of osteoporosis. The development of osteoporotic changes in patients with osteoarthritis and in combination with obesity is accompanied by an increase in the synthesis of osteoprotegerin, a glycoprotein involved in the processes of bone tissue remodeling.
The analysis of BMI in young people
(Харківський національний медичний університет, 2018-05-16) Kumetchko, A.; Kovalenko, A.
The BMI is simplest and significant indicator in preventive medicine in order to define the groups of people having risk factors of any pathology development. 2. The significant correlation between reduced BMI indicator and gender has been found in females thus concluding that additional examination aimed at revealing of reason of underweight is highly recommended.
The influence of the overweight and obesity on the degree of hypertension
(2014-05-15) Sukchomlin, Nikolay; Balashova, Tatyana; Gerasimchuk, Nina
: In Ukraine, as well as throughout the world, arterial hypertension remains one of the most important problems. This is due to the fact that hypertension is a major risk factor of coronary heart disease and cerebrovascular disease, which is determined at 88.1% death rate from diseases blood circulation system, characterized by the high prevalence. In our time it is generally accepted that the level of increase in the frequency of obesity among the population in developed countries is of the alarming rate, so this phenomenon is compared with the epidemic (WHO, 2000; Haffner S. et al., 2003; Eckel RH et al., 2005). The clinical significance of this fact consists in that overweight and obesity are potential factors of the risk for hypertension. Epidemiological studies have established a significant correlation between body mass index (BMI), waist circumference and blood pressure (Brown CD et al., 2000; Wilsgaard T. et al., 2000; Poirier P. et al., 2005) . The probability of developing hypertension in patients with overweight are 50% higher than in patients with normal body weight (Vasan RS et al., 2001).
The interconnection between individual circadian rhythms and eating behavior as one of main reasons of overweight and obesity in young people
(2019-05-15) Hloba, Nataliia; Isaieva, Inna; Karmazina, Iryna; Marakushyn, Dmytro; Hloba, Oleksandr
The article features the problem of overweight and obesity and its prevalence among young people. Possible negative outcomes of mentioned states and mechanisms of obesity development are listed. The programs of obesity prevention and their main directions are mentioned. The role of individual circadian rhythms on metabolism of a person is explained. The original research results regarding the interconnection between individual circadian clock, eating habits and body mass index are presented. Conclusions were made about influence of biological rhythms and eating patterns synchronization on body weight and metabolism and their application as simple and efficient way of obesity prevention in young people.
The relationship between vaspin, TNF-Α levels and the parameters of carbohydrate metabolism in patients with type 2 diabetes mellitus
(2019) Pylov, Danylo
It is well known that the adipose tissue is an active endocrine organ. It produces a large number of substances which are involved in the regulation of metabolic and physiological processes. One of representatives is vaspin- adipokine, which is involved in some obesity-related disease states such as insulin resistance. Aim. To determine the level of vaspin and TNF-α in blood of patients with type 2 diabetes mellitus depending on parameters of carbohydrate metabolism and body mass index.
Взаимосвязь возраста, индекса массы тела и морфологии левого желудочка у больных гипертонической болезнью с ожирением
(ДУ «Інститут геронтології імені Д.Ф. Чеботарьова НАМН України», 2013-01-25) Гончарь, Алексей Владимирович; Гончарь, Олексій Володимирович; Honchar, Oleksii; Щедров, Александр Михайлович; Щедров, Олександр Михайлович; Хмара, Анатолий Тарасович; Хмара, Анатолій Тарасович; Хмара, Валентина Тимофеевна; Хмара, Валентина Тимофіївна
Актуальность. Гипертоническая болезнь (ГБ) является наиболее распространенным возраст-ассоциированным заболеванием сердечно-сосудистой системы, характеризующимся прогрессирующим течением с поражением органов-мишеней. Особо неблагоприятным является сочетание ГБ с ожирением в рамках метаболического синдрома. Одним из наиболее ранних системных проявлений ГБ является ремоделирование миокарда левого желудочка (ЛЖ). Цель. Выявить взаимосвязь возраста, индекса массы тела (ИМТ) и особенностей морфологии левого желудочка у пациентов с гипертонической болезнью на фоне ожирения. Материалы и методы. Обследовано 56 пациентов (23 мужчины и 33 женщины) в возрасте от 46 до 77 лет с ГБ I-II ст. и ожирением. Группу сравнения составили 26 больных с ГБ на фоне нормальной или умеренно повышенной массы тела (12 мужчин и 14 женщин). Всем больным было проведено ультразвуковое исследование сердца в М- и В-режимах с расчетом массы и индекса массы миокарда (ММЛЖ, ИММЛЖ), индекса сферичности ЛЖ в диастолу и систолу (Исфд, Исфс), а также объёмных параметров левого желудочка (КДО, КСО, УО, МОК) и соответствующих индексов. Результаты. При анализе полученных данных среди больных с 1 ст. ожирения статистически значимых зависимостей между возрастом обследованных и показателями, характеризующими морфологию ЛЖ, выявлено не было; в то же время отмечалась значимая прямая корреляционная связь между ИМТ и КДР (r=0,48, p=0,018), КСР (r=0,57, p=0,004), Исфд (r=0,43, p=0,035), Исфс (r=0,51, p=0,004), КДО (r=0,48, p=0,017), КДИ (r=0,37, p=0,05), КСО (r=0,53, p=0,007), КСИ (r=0,52, p=0,01), а также обратная связь ИМТ с ФВ ЛЖ (r=-0,42, p=0,04). В группе пациентов с 2-3 ст. ожирения была выявлена значимая прямая корреляционная связь между возрастом и ММЛЖ (r=0,55, p=0,011), ИММ (r=0,66, p=0,02), Исфс (r=0,46, p=0,04), КДО (r=0,49, p=0,029), КДИ (r=0,54, p=0,014), УО (r=0,53, p=0,016), УИ (r=0,59, p=0,006), СИ (r=0,46, p=0,041); корреляционных зависимостей между ИМТ и ультразвуковыми параметрами ЛЖ выявлено не было. В группе сравнения была выявлена связь возраста с ММЛЖ (r=0,44, p=0,039) и ИММ (r=0,51, p=0,016), ИМТ не влиял на исследуемые параметры. Возраст и ИМТ не были связаны между собой ни в одной группе. Выводы. Полученные результаты свидетельствуют о наличии значимых связей между возрастом, ИМТ и морфологией ЛЖ у больных ГБ с ожирением. При этом у пациентов с ожирением 1 ст. большее влияние на исследуемые параметры имел ИМТ, в группе же больных с 2-3 ст. ожирения – возраст обследуемых.
Рівень обестатину у хворих на артеріальну гіпертензію та цукровий діабет 2типу в залежності від наявності ожиріння
(2015) Кравчун, Павло Григорович; Табаченко, Олена Сергіївна
Обестатин - гормон, секретируется клетками слизистой желудка и кишечника, открыт в 2005 году учеными Стэндфордского университета. Обестатин регулирует функцию адипоцитов и защищает от патологических последствий, вызванных резистентностью к инсулину. Целью исследования было проанализировать влияние обестатина на массу тела больных с артериальной гипертензией (АГ) и сахарным диабетом (СД) 2 типа, а также оценить характер связей между антропометрическими параметрами (объем талии (ОТ), объем бедер (ОБ), индекс массы тела (ИМТ)) и обестатином в данной когорте больных в зависимости от наличия или отсутствия ожирения (ОЖ). Коморбидность АГ и СД 2 типа ассоциируется с высокой активностью обестатина, по сравнению с группой пациентов с АГ без СД 2 типа и с контрольной группой, что свидетельствует в пользу компенсаторной реакции на данном этапе. Присоединение ОЖ к АГ и СД 2 типа сопровождается дезадаптивным снижением обестатина сравнению с больными без ОЖ, может рассматриваться фактором развития и прогрессирования ОЖ с учетом анорексичных свойств обестатина.
Характеристика пубертатних маткових кровотеч з урахуванням інсулінорезистентності
(2012) Дынник, Александра Алексеевна; Диннік, Олександра Олексіївна; Dynnik, Oleksandra
Обследована 131 пациентка с пубертатными маточными кровотечениям в возрасте 11−18 лет. Проведен анализ клинической картины ПМК с учетом массы тела и инсулинорезистентности. Выявлено, что у 40,3 % пациенток с ПМК отмечается повышенный индекс НОМА, причем это регистрируется как у больных с повышенной массой тела, так с физиологическими ее параметрами и наличием дефицита. Показано, что имеются особенности клинического течения ПМК, зависящие как от массы тела, на которой они формируются, так и наличия инсулинорезистентности.