Кафедра фармакології та медичної рецептури

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Browsing Кафедра фармакології та медичної рецептури by Author "Bondariev, Yevhen"

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    Study of membrane-stabilizing and anti-inflammatory activity of tincture from herba Bidens Tripartita L
    (©2011-2022 SILAE - Società Italo-Latinoamericana di Etnomedicina / PharmacologyOnLine, 2021-12-30) Oproshanska, Tetiana; Mishchenko, Oksana; Shapoval, Olga; Khvorost, Olga; Koiro, Olga; Bondariev, Yevhen
    Bidens tripartita L. is herbaceous plant of the Asteraceae family, which is widely used in medicine as an anti-inflammatory, diuretic, choleretic, diaphoretic, antimicrobial, antifungal, immunomodulatory agent and improve metabolism. The chemical composition of the herb is represented by phenolic compounds (butein, marein, isocoreopsin, flavanomarein, sulfuretin, sulfurein, marimetimetin, maritimein, luteolin, cinaroside), hydroxycinnamic acids (chlorogenic, caffeine, umélefene) tannins, polysaccharides, macro- and micro elements, fatty acids. The aim of the work is to establish the antiinflammatory and membrane-stabilizing activity of the tincture from the herb of Bidens tripartita. Tincture from the herb of Bidens tripartita was prepared by the classical method of maceration at room temperature, the ratio of plant raw materials to the finished product 1:5, extractant 50% ethyl alcohol. Studies of the effect of tincture on the state of cell membranes were performed under conditions of spontaneous hemolysis of rat erythrocytes in Jager F. C. Influence of tincture doses of 0.1 and 0.2 ml/kg, which were administered in a maintenance regimen for 7 days, with an experimental mechanism of inflammation, mainly carried out in the model of acute carrageenan edema of the foot in white rats weighing 180-200 g according to the method. The presence of antiexudative activity of Bidens herbs tincture is due to the composition and complex effect of biologically active substances of the studied Bidens tincture. According to the manifestation of membrane stabilizing activity in the model of spontaneous hemolysis of erythrocytes, it was found that the use of Bidens herbs tincture at a dose of 0.1 ml/kg was not characterized by a significant manifestation of membrane stabilizing activity, while the administration of Bidens herbs tincture at a dose of 0.2 ml/kg contributed to the manifestation of membrane-stabilizing activity.