Кафедра фармакології та медичної рецептури
Permanent URI for this communityhttps://repo.knmu.edu.ua/handle/123456789/193
Browse
Browsing Кафедра фармакології та медичної рецептури by Author "Aleksandrova, Alina"
Now showing 1 - 20 of 29
- Results Per Page
- Sort Options
Item Adrenergic agents(2015-11-05) Aleksandrova, AlinaItem Aducanumab and its uses in treatment of alzheimers disease(2017) Aleksandrova, Alina; Mukherjee, P.Item Assessment of influence of synthetic matrix metalloproteinases inhibitor doxycycline on the total proteolytic activity of blood in experimental thermal burns in rats(2018) Aleksandrova, AlinaThe effect of synthetic inhibitors of matrix metalloproteinases (MMP) doxycycline on the total proteolytic activity (TPA) in blood in an expiremental thermal ingury in rats has been studied. It is shown that thermal burn without treatment, in experimental rats, accompanied by increased levels of TPA throughout the study period. The use of reference drugs thiotriazoline and methyluracil leads to a reduction of these indicators by the end of the experiment (28-th day). Synthetic MMP inhibitor doxycycline (especially in a dose of 30 mg/kg) was superior to comparative preparations by the ability to normalize TPA level in blood of the thermal damage.Item Autonomic nervous system. Cholinergic agonists (Cholinomimetics). Cholinergic antagonists (Cholinoblockers)(2015-09) Aleksandrova, AlinaItem Belsomra and its use(2015-05) Aleksandrova, Alina; Onuchukwu, ChibuzorItem Changes of the TNF-α level in the rat blood in the treatment of thermal burns by synthetic inhibitor of matrix metalloproteinase,s doxycycline(2018-01) Aleksandrova, Alina; Koampan, AbenaItem Cholinoblockers(2015-11-05) Aleksandrova, AlinaItem Cholinomimetics(2015-10-21) Aleksandrova, AlinaItem Effect of plants neurostimulating and sedating action on human's body(2015-05) Aleksandrova, Alina; Petruk, B.Item Estimation of the lipid peroxide oxidation processes and antioxidant protection in the treatment of rats thermal burning by doxycycline as a synthetic inhibitor of matrix metalloproteinases in experiment(2019-11) Aleksandrova, Alina; Iermolenko, TamaraAim – to assess the effects of doxycycline on the state of lipid peroxidation processes and the activity of the antioxidant system. The study was performed on 144 rats of the WAG population weighing 200-250 g (6 rats in each group). Animals with thermal burns were injected with the test drug doxycycline, as well as reference drugs — thiotriazolin and methyluracil orally in starch suspension after thermal exposure and daily during the entire experiment period (28 days). Animals were removed from the experiment in accordance with the rules of bioethics on the 7th, 14th, 21st and 28th day. As a result of the research, the most intense influence of doxycycline on the processes of lipid peroxidation in the blood serum of rats was found - a decrease in DC activity by the end of the experiment (regardless of dose) and TBA-AP starting from the 14th day of observation reaching the value of intact rats (at a dose of 30 mg / kg). At the same time, an increase in the activity of enzymes of the antioxidant system was noted - the level of catalase from the 14th day (significantly higher than the control group regardless of dose) and the level of ceruloplasmin (from the second week of observation the indicator reached intact values at a dose of 30 mg / kg). Reference drugs were inferior to doxycycline in their effectiveness. The data obtained may indicate the possibility of reducing the healing time of a thermal burn due to the suppression of excessive free radical oxidation activity and activation of antioxidant protection.Item Formation of global outlook of medical students in higher education instituties(2019-05) Aleksandrova, Alina; Iermolenko, TamaraItem General farmacology(2015-09) Aleksandrova, AlinaItem General farmacology 1 medical : lecture for medical students of 3 year(2015-09-24) Aleksandrova, AlinaItem General farmacology 2 medical(2015-09-24) Aleksandrova, AlinaItem Influence of doxycycline on proinflammatory cytokines TNF-α in the treatment of thermal burn in rats(2014-05-15) Aleksandrova, AlinaItem Influence of doxycycline on the level of anti-inflammatory cytokine IL-4 in the experimental treatment of thermal burn in rats(2018-04) Iermolenko, Tamara; Aleksandrova, AlinaItem Influence of sodium salt of poly-(2,5-dihydroxyphenylene)-4-thiosulphate on the level of lactate dehydrogenase and alkaline phosphatase of serum rats with acute renal failure(2016) Iermolenko, Tamara; Gordiychuk, Daria; Aleksandrova, Alina; Onashko, Y.Item Influence of Telmisartan to the modification of cardiovascular risk factors in patients with 2nd type diabetes(2015-01) Abdullaieva, Sona; Hasanova, Aynur; Aleksandrova, AlinaItem Matrix metalloproteinases and their role in angiogenesis in healing of burn wounds(2018) Aleksandrova, AlinaItem Nephroprotective Activity of Sodium Poly-(2,5-Dyhidroksyfenilen)-4-Thiosulfate acid Under Acute Renal Injury(Global Research Online, India, 2017-05) Iermolenko, Tamara; Karnaukh, Ella; Gordiychuk, Daria; Onashko, Yulia; Aleksandrova, AlinaIn the executed work nephroprotective effect of PDТ-Na is setted, which by most indicators exceed action of a reference drug thiotriazoline, manifested in conditions of experimental models of acute renal injury (ARI). According to mechanisms of kidney damage by applied models degree of protective action of PDT-Na in these conditions is different too: It turns out more in the background of the sample kidney damage by the type of crash-syndrome, that is evidence of renal antitoxic mechanism of its protection. Somewhat less this effect is manifested at gentamycine nephropathy, where is nephrotoxic factor accumulation gradually caused similar renal pathology and evidence of connection mechanism of PDT-Na with epithelium protective properties of the drug. Even less severe, but sufficiently, it is observed at the conditions of ethylene glycol model in which kidney disease combined with central nervous system disorders, and causes general antitoxic mechanism of nephroprotective PDT-Na action. In all models of ARI kidney protection is implemended by warning of enzymopathy development and normalization of blood electrolyte, which differ quantitatively. At the same time, common quality properties of PDT-Na, obviously, related to its nonspecific effects relating to anti-hypoxic and antioxidant actions which determine the direction of our further research.