Browsing by Author "Cherpita, Valentyna"

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Clinical significance of visfatin and homocysteine in forecasting of osteoarthritis in women of pre-and postmenopausal age with type 2 diabetes mellitus
(2022) Zhuravlyova, Larysa; Cherpita, Valentyna
Type 2 diabetes mellitus is a leading cause of death and has high prevalence. Patients with type 2 diabetes mellitus are often diagnosed with osteoarthritis, the vast majority of cases are found in pre- and postmenopausal women due to decreased estrogen levels, as well as their numerous hormonal and metabolic disorders. The study determined the prognostic significance of visfatin and homocysteine in the development of osteoarthritis in pre- and postmenopausal women with type 2 diabetes mellitus and built a prognostic model for the development of osteoarthritis. We studied 82 pre- and postmenopausal women: 20 women (1 group) with isolated type 2 diabetes mellitus and 62 women (group 2) with comorbid type 2 diabetes mellitus and osteoarthritis. The study found that reliable predictors of osteoarthritis in women with type 2 diabetes mellitus in pre- and postmenopausal women were waist circumference, levels of very-low-density lipoproteins, visfatin and homocysteine, which were included in a prognostic model with high levels of sensitivity and specificity: 96.8 % and 90.0 %, respectively. The value of the area under the curve was 0.992±0.006 [95.0 % CI 0.979–1.000], p<0.001. The obtained prognostic model opens new ways of timely diagnosis of early osteoarthritis in pre- and postmenopausal women with type 2 diabetes mellitus.
Determination of the relationship of visphatin and homocysteine levels with indicators of glucose metabolism and lipid metabolism in peri- and postmenopause women with type 2 diabetes mellitus and osteoarthritis
(2023) Zhuravlyova, Larysa; Cherpita, Valentyna
Determination of the relationship of visphatin and homocysteine levels with indicators of glucose metabolism and lipid metabolism in peri- and postmenopause women with type 2 diabetes mellitus and osteoarthritis.
The level of visfatin and indicators of carbohydrate and lipid metabolism in postmenopausal women with the combined pathology of type 2 diabetes and osteoarthritis
(2022) Cherpita, Valentyna; Zhuravlyova, Larysa
Purpose: to determine the interdependence of indicators of glucose metabolism and lipid metabolism with levels of visfatin (VF) in women with T2DM and OA in pre- and postmenopause.