Tuberculosis and smoking are among the most pressing issues in the modern health care system in the world. Tuberculosis patients who smoke are confirmed to have reduced the effectiveness of anti-tuberculosis therapy, unsatisfactory prognosis of a specific disease, higher risk of treatment failure and mortality from this disease. Diseases such as HIV and alcoholism increase ineffective treatment in tobacco smokers. In addition, smoking leads to increased virulence of the causative agent of tuberculosis - Mycobacterium tuberculosis.